Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Shape-adjustable hydrogel patch for wound repair and preparation method thereof

A hydrogel patch and wound repair technology, which is applied in bandages, absorbent pads, additive processing, etc., can solve the problems of poor skin adhesion, difficult to control the shape, and poor fitting effect, so as to promote wound repair , the preparation method is simple, the effect of promoting cell proliferation and differentiation and angiogenesis

Inactive Publication Date: 2021-07-23
NANJING DRUM TOWER HOSPITAL
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the skin adhesion of hydrogel materials is poor, and the shape is difficult to control, and the bonding effect with the skin is not good, and there are problems such as dressing shifting and falling off, which restricts its wide application in wound repair.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Shape-adjustable hydrogel patch for wound repair and preparation method thereof
  • Shape-adjustable hydrogel patch for wound repair and preparation method thereof
  • Shape-adjustable hydrogel patch for wound repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] The invention provides a method for preparing an individualized hydrogel patch for wound repair, comprising the following steps:

[0031] 1) Preparation of individualized black visor 1: According to the special shape of the wound, such as lace (1-11), pentagon (1-12) and oval (1-13), use software to draw the corresponding source file And 3D print hollow black shading boards, which have lace-shaped (1-21), pentagonal (1-22) and oval (1-23) hollow structures (both long diameters are 1.0cm), to obtain individualized black shading plate;

[0032] 2) Preparation of individualized hydrogel patch: configure hydrogel solution, cover the hollow black shading plate, and irradiate with ultraviolet light, remove the surrounding ungelled solution, and obtain lace-shaped (2-1), pentagonal Shape (2-2) and ellipse (2-3) hydrogels to make individualized hydrogel patches.

[0033] Wherein, the hydrogel raw material solution is methacrylated gelatin (GelMA), and the hydrogel raw materia...

Embodiment 1

[0043] A hydrogel patch that is individually designed based on the shape of the wound is prepared according to the following method:

[0044] (1) Prepare a black shading baffle based on the shape of the wound

[0045] Individualized black shading baffle: According to the special shape of the wound, take the lace shape 1-11, pentagon 1-12 and oval 1-13 as examples, design the 3D printing source file, and print out the black shading corresponding to the hollow shape Baffles 1-21, 1-22, 1-23.

[0046] (2) Preparation of simple GelMA hydrogel solution

[0047] First, weigh 0.15g of GelMA powder, dissolve it in 1.5mL of pure water, put it in a 45°C water bath for 10 minutes, and obtain a clear GelMA aqueous solution, add 0.015g of 2-hydroxy-2-methylpropiophenone, and ultrasonically Shake for 5 minutes to obtain a clear pure GelMA solution.

[0048] (3) Preparation of GelMA / VEGF hydrogel solution

[0049]First, weigh 0.15g of GelMA powder, dissolve it in 1.5mL of pure water, put...

Embodiment 2

[0053] Hydrogel patch for wound repair on circular skin wounds in rats

[0054] Taking the hydrogel patch prepared in Example 1 as an example, anesthetize 18 female rats with a weight of 200-250 g by intraperitoneal injection of 10% (w / v) chloral hydrate, prepare the skin on the back, and make a skin with a diameter of 1.0 cm. Full thickness wound;

[0055] The rats of the above-mentioned back skin defect model were randomly divided into control group, GelMA hydrogel group and GelMA / VEGF hydrogel group, with 6 rats in each group: control group: no treatment; GelMA hydrogel group: GelMA water Put the gel patch into the skin wound, press gently to make the patch fit the wound completely; GelMA / VEGF hydrogel group: put the GelMA / VEGF hydrogel patch into the skin wound, press gently to make the paste During the treatment period, the dynamic process of wound healing in rats was observed, and the healing status was recorded. After 9 days of treatment, the rats were anesthetized, an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a shape-adjustable hydrogel patch for wound repair and a preparation method thereof. The preparation method comprises the following steps: designing a pattern shape of an individualized black shading plate in a guiding manner according to the appearance of a wound, drawing a source file of the corresponding pattern by using a 3D Max software, and preparing a hollow black shading plate through 3D printing. The hollow black shading plate is a hollow-structured individualized black shading plate with a specific design shape. Photo-crosslinking polymerization of methylacryloylated gelatin GelMA is carried out by using the shading plate, so as to prepare the shape-adjustable hydrogel patch. The prepared hydrogel patch can completely fit with different wound surfaces in shape. Vascular endothelial growth factor VEGF loaded in the hydrogel can promote cell proliferation and differentiation and induce angiogenesis while protecting the wound surfaces, thereby accelerating healing of wound surfaces. The hydrogel patch is diversified in functions, remarkable in curative effect and wide in application range.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an individualized hydrogel patch for wound repair and a preparation method thereof. Background technique [0002] Daily trauma and surgery are the main causes of wounds, and wound repair is a concern in the world of healthcare. Common wound repair methods include surgical suture, debridement and drainage, and covering with medical dressings. Due to the poor biocompatibility of materials and poor wound adhesion effect of medical dressings, the wound repair effect needs to be improved. [0003] Hydrogel dressings are a major way to promote wound healing due to their good biocompatibility. However, the skin adhesion of hydrogel materials is poor, and the shape is difficult to control, and the bonding effect with the skin is not good, and there are problems such as dressing displacement and falling off, which restricts its wide application in wound repair. Design a hy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/44A61L15/42B33Y10/00B33Y70/00B33Y80/00
CPCA61L15/32A61L15/44A61L15/42B33Y10/00B33Y70/00B33Y80/00A61L2300/412A61L2300/414C08L89/00
Inventor 赵远锦黄榕康王月桐池俊杰张大淦
Owner NANJING DRUM TOWER HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com