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Implantable hydrogel fiber grating glucose sensor, preparation method thereof and measurement system

A technology of glucose sensor and fiber grating, which is used in sensors, measuring devices, diagnostic recording/measurement, etc., can solve the problems of hard fiber grating material, easy damage to biological tissues, poor biocompatibility, etc., and achieves soft texture, good mechanical properties, The effect of reducing the risk of damaging biological tissue

Active Publication Date: 2021-07-27
BEIHANG UNIV
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Problems solved by technology

However, common fiber gratings are usually written by glass optical fibers or plastic optical fibers, which have poor biocompatibility, and long-term implantation will cause human immune and inflammatory reactions
Moreover, the fiber grating material is hard and easy to damage biological tissues

Method used

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  • Implantable hydrogel fiber grating glucose sensor, preparation method thereof and measurement system
  • Implantable hydrogel fiber grating glucose sensor, preparation method thereof and measurement system
  • Implantable hydrogel fiber grating glucose sensor, preparation method thereof and measurement system

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Embodiment Construction

[0040] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, not all of them. the embodiment. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0041] The glucose-sensitive hydrogel material optical fiber grating prepared by the invention, the specific preparation process is as follows:

[0042] Step (1) Synthesis and configuration of precursor solution: mix AAm, crosslinking agent BIS, 3-APBA into 1mL dimethyl sulfoxide (DMSO) solution at a molar mass ratio of 78.5:1.5:20mol%, stir well and add 2%w / v DEAP photoinitiator, ...

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Abstract

The invention discloses an implantable hydrogel fiber grating glucose sensor, a preparation method thereof and a measurement system. A biocompatible glucose-sensitive hydrogel material is adopted as a base material, and a mask method is combined to prepare a fiber bragg grating, so that wavelength-dependent glucose detection is realized. The glucose diffuses into a hydrogel network and is specifically combined with a glucose sensitive group, so that the effective refractive index and the period of the fiber bragg grating are changed, and the resonant wavelength drifts. The real-time and quantitative detection of glucose can be realized by detecting the wavelength drift distance of the fiber bragg grating. In addition, in order to eliminate the influence of environment and light source instability factors, the invention provides a measurement system based on double fiber bragg gratings. The hydrogel material fiber bragg grating has soft biomechanical characteristics and excellent biocompatibility, and is suitable for long-term continuous blood glucose monitoring.

Description

[0001] (1) Technical field [0002] The invention relates to an implantable hydrogel fiber grating glucose sensor, a preparation method and a measurement system, which are used for long-term continuous blood sugar monitoring and belong to the technical field of bio-optical detection and organic material application. [0003] (2) Background technology [0004] As the most important test content in medical testing, glucose quantitative analysis plays an important role in blood testing, and also frequently appears in the production and processing of various feed and food, biochemistry and other fields. The blood sugar concentration of normal people is 4-8mM, but in diabetic patients, due to the lack of insulin in the body or the inability of insulin to play a normal physiological role in the target cells, the blood sugar concentration is much higher than the normal level. Sustained high blood sugar levels can lead to serious complications including diabetic retinopathy, kidney fai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1495A61B5/1455G01N21/41G01N21/84
CPCA61B5/1495A61B5/1455A61B5/14532G01N21/41G01N21/84
Inventor 郭晶晶徐立军尚策付博
Owner BEIHANG UNIV
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