Preparation method of multi-responsive self-healing self-adhesive hydrogel

A hydrogel and responsive technology, applied in the field of preparation of multi-responsive self-healing self-adhesive hydrogels, can solve the problems of lack of tissue adhesion and cell affinity, poor mechanical properties of hydrogels, etc. , to achieve the effect of wide application potential, simple preparation method and good biocompatibility

Active Publication Date: 2021-08-03
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for preparing a multi-responsive self-healing self-adhesive hydrogel in order to overcome the problems of poor mechanical properties, lack of tissue adhesion and cell affinity of the existing

Method used

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  • Preparation method of multi-responsive self-healing self-adhesive hydrogel
  • Preparation method of multi-responsive self-healing self-adhesive hydrogel
  • Preparation method of multi-responsive self-healing self-adhesive hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0025] At room temperature, take 36.9 g of bacterial cellulose suspension with a mass fraction of 8.13 mg / g (about 0.3 g of bacterial cellulose), disperse it into 30 mL of tris buffer with a pH value of 8.5, and then add 0.2 g Tannic acid, stir evenly, after the prepolymerization reaction for 6 hours, add 0.2 g of cystamine dihydrochloride to continue the reaction for 1.5 hours to obtain the bacterial cellulose suspension coated with tannic acid, and successfully introduce disulfide bonds, and the suspension Centrifuge and wash for later use.

[0026] Add 5g of polyvinyl alcohol into 45mL of deionized water and heat to 95°C, stir for 2 hours until the polyvinyl alcohol is completely dissolved, add the centrifuge obtained in the previous step into the polyvinyl alcohol solution and continue to stir evenly, then add 5mL of the concentration to 0.04g / Add 1 mL of borax solution dropwise at a rate of 1 mL / min, stir for 20 min, and then naturally cool to room temperature to obtain ...

Embodiment 2

[0030] At room temperature, take 36.9 g of bacterial cellulose suspension with a mass fraction of 8.13 mg / g (about 0.3 g of bacterial cellulose), disperse it into 30 mL of tris buffer with a pH value of 8.5, and then add 0.5 g Tannic acid, stir evenly, after the prepolymerization reaction for 6 hours, add 0.2 g of cystamine dihydrochloride to continue the reaction for 1.5 hours to obtain the bacterial cellulose suspension coated with tannic acid, and successfully introduce disulfide bonds, and the suspension Centrifuge and wash for later use.

[0031] Add 5g of polyvinyl alcohol into 45mL of deionized water and heat to 95°C, stir for 2 hours until the polyvinyl alcohol is completely dissolved, add the centrifuge obtained in the previous step into the polyvinyl alcohol solution and continue to stir evenly, then add 5mL of the concentration to 0.04g / Add 1 mL of borax solution dropwise at a rate of 1 mL / min, stir for 20 min, and then naturally cool to room temperature to obtain ...

Embodiment 3

[0034] At room temperature, take 36.9 g of bacterial cellulose suspension with a mass fraction of 8.13 mg / g (approximately containing 0.3 g of bacterial cellulose), disperse it into 30 mL of tris buffer with a pH value of 8.5, and then add 0.8 g Tannic acid, stir evenly, after the prepolymerization reaction for 6 hours, add 0.2 g of cystamine dihydrochloride to continue the reaction for 1.5 hours to obtain the bacterial cellulose suspension coated with tannic acid, and successfully introduce disulfide bonds, and the suspension Centrifuge and wash for later use.

[0035] Add 5g of polyvinyl alcohol into 45mL of deionized water and heat to 95°C, stir for 2 hours until the polyvinyl alcohol is completely dissolved, add the centrifuge obtained in the previous step into the polyvinyl alcohol solution and continue to stir evenly, then add 5mL of the concentration to 0.04g / Add 1 mL of borax solution dropwise at a rate of 1 mL / min, stir for 20 min, and then naturally cool to room tem...

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Abstract

The invention relates to a preparation method of a multi-responsive self-healing self-adhesive hydrogel. According to the invention, polyvinyl alcohol/borax is used as a main body structure of the hydrogel, and bacterial cellulose is added to improve the mechanical properties of the hydrogel. Tannic acid rich in benzenediol groups is used as a monomer for providing hydrogel adhesion, and a quinone structure obtained by oxidation of the tannic acid and an amino group of cystamine dihydrochloride are subjected to a Schiff base or Michael addition reaction to introduce disulfide bonds, so the hydrogel is endowed with redox responsiveness. The hydrogel is prepared through a boric acid ester bond, a hydrogen bond, pi-pi stacking and the like, and the defects that traditional polyvinyl alcohol hydrogel is poor in mechanical property, lack of tissue adhesion and the like are overcome. The hydrogel has good biocompatibility, multiple responsiveness, excellent mechanical property, self-adhesion and the like, so the application range of the hydrogel is expanded.

Description

technical field [0001] The invention belongs to the field of preparation of multi-responsive hydrogels, and in particular relates to a preparation method of multi-responsive self-healing and self-adhesive hydrogels. Background technique [0002] Traditional polyvinyl alcohol / borax-based hydrogels are widely used because of their sterility and non-toxicity, but such hydrogels lack sufficient adhesion and cell affinity to tissues and have poor mechanical properties, making them useful as biological dressings. And the application of medical materials is limited. Contents of the invention [0003] The purpose of the present invention is to provide a method for preparing a multi-responsive self-healing self-adhesive hydrogel in order to overcome the problems of poor mechanical properties, lack of tissue adhesion and cell affinity of the existing hydrogel. Using polyvinyl alcohol, tannic acid, bacterial cellulose and cystamine dihydrochloride as raw materials, the hydrogel prep...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08L1/08C08K3/38C08B15/00
CPCC08J3/075C08B15/00C08J2329/04C08J2401/08C08K3/38
Inventor 贺金梅衣晓彤魏新晶于琛刘兴原钱婧婷
Owner HARBIN INST OF TECH
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