Polypeptide sequence and application thereof

A polypeptide sequence and sequence technology, applied in the field of polypeptide sequence and its application, can solve the problems of increasing the difficulty of treatment of Streptococcus pneumoniae infection, exacerbating the condition of patients, enhancing inflammatory response, etc., and achieving the effect of easy large-scale production

Active Publication Date: 2021-08-20
SOUTHWEST MEDICAL UNIVERISTY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, under the inflammatory response caused by influenza virus infection, Streptococcus pneumoniae can proliferate and then enhance the inflammatory response, leading to the aggravation of the patient's condition
In addition, due to the large number of serotypes of Streptococcus pneumoniae and the prevalence of drug-resistant strains, the treatment of Streptococcus pneumoniae infection is more difficult.

Method used

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  • Polypeptide sequence and application thereof
  • Polypeptide sequence and application thereof
  • Polypeptide sequence and application thereof

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Embodiment Construction

[0031] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0032] It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0033] Hereinafter, the synthesis and effect of the polypeptide sequence described in the present invention will be described in detail, which is divided into the following 6 parts:

[0034] 1. According to the antigenic epitope of influenza virus surface protein hemagglutinin (HA), carry out the synthesis of relevant polypeptides and conduct antigenicity detection. Three antigenic epitopes of HA were synthesized in total, and the amino acid sequences are shown in SEQ ID No.1-3. It is found that the sequence shown in SEQ ID No.1 has the strongest immunogenicity through detection o...

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Abstract

The invention discloses a polypeptide sequence and application thereof. The polypeptide sequence comprises a choline binding sequence at an N terminal and a specific epitope sequence at a C terminal, wherein the N terminal is a part with choline binding activity in a ChBp sequence; and the terminal C is an antigen epitope of influenza virus surface protein hemagglutinin HA. The amino acid sequence at the N terminal of the polypeptide sequence has streptococcus pneumoniae binding activity, the C terminal has influenza antigen characteristics, and the polypeptide sequence can induce influenza antibody binding in the presence of influenza antibodies, so that the growth rate of streptococcus pneumoniae, adhesion to the cell surfaces and autolysis are reduced; and the co-presence of the polypeptides and the influenza antibodies in mice can reduce the colonization of the Streptococcus pneumoniae.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a polypeptide sequence and its application. Background technique [0002] Streptococcus pneumoniae is an important pathogen that causes community-acquired pneumonia, bronchitis, sinusitis, otitis media, sepsis, and meningitis. According to the World Health Organization (WHO), more than 1.6 million people worldwide die each year from Streptococcus pneumoniae infection. Streptococcus pneumoniae is an opportunistic pathogen that can colonize the human nasal cavity asymptomatically. The carrier rate of Streptococcus pneumoniae in the upper respiratory tract of healthy adults is about 5%-10%, and the carrier rate of infants under 2 years old is about 22%. Between -45%. After the body's immunity is weakened or infected by other pathogens, Streptococcus pneumoniae may change to a proliferative state, leading to the occurrence of body diseases or aggravation of symptoms. Among the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K19/00A61K39/145A61K39/385A61P31/04
CPCC07K14/005A61K39/12A61P31/04C12N2760/16122C12N2760/16134C07K2319/40C07K2319/33A61K2039/6068Y02A50/30
Inventor 张志坤姬红生
Owner SOUTHWEST MEDICAL UNIVERISTY
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