Application of kaurane compound in preparation of medicine for preventing and treating inflammatory bowel disease

A technology for inflammatory bowel disease and kauri, which is applied to the application field of kauri compounds in the preparation of medicines for preventing and treating inflammatory bowel disease, and can solve the problems of patient infection, unreported, easy to fail and the like
CN113304133AActive Publication Date: 2021-08-27KEY PHARMA BIOMEDICAL INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KEY PHARMA BIOMEDICAL INC
Publication Date
2021-08-27

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Abstract

The invention discloses an application of a kaurane compound in preparation of a medicine for treating inflammatory bowel disease. The kaurane compound can obviously reduce the weight of a dextran sodium sulfate induced (DSS) enteritis model mouse, improve the shortening of the colon length of the colitis model mouse, relieve the infiltration of colon tissue inflammatory cells of the colitis model mouse, reduce the rise of leukocytes, neutrophils, lymphocytes and monocytes of the colitis model mouse, reduce the expression of inflammatory factors, and achieve the immunoregulation function on intestinal tracts. The mechanism of the kaurane compound may be known by adjusting polarization of macrophages and differentiation of T cells, and the kaurane compound can relieve the inflammatory reaction of DSS-induced inflammatory bowel disease model mice and improve the severity of the inflammatory bowel disease, and can be used for preparing drugs or health care products for treating the inflammatory bowel disease.
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Description

[0001] field of invention

[0002] The invention discloses a kauritanes compound for alleviating and treating inflammatory bowel disease. The invention discloses that the kauritanes compound can obviously reduce the body weight of enteritis model mice induced by dextran sodium sulfate (DSS), improve the shortening of the colon length of the colitis model mice, and reduce the infiltration of inflammatory cells in the colon tissue of the colitis model , reduce the increase of white blood cells, neutrophils, lymphocytes and monocytes in colitis model mice, and reduce the expression of inflammatory factors. The invention discloses the regulating effect of the kauritanes on macrophages and T cells when inflammatory bowel disease occurs. Background technique

[0003] Inflammatory bowel disease is a chronic intestinal inflammatory disease with unclear pathogenesis, mainly including ulcerative colitis (Ulcerative Colitis, UC) and Crohn's disease (Crohn's disease, CD). UC is a chroni...

Claims

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