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Hyaluronic acid baicalein iron nanoparticles and preparation method thereof

A technology of hyaluronic acid and sodium hyaluronate, applied in the field of medicine, can solve the problems of low bioavailability and poor water solubility of baicalein, achieve high repeatability, improve anti-tumor efficacy, and broad biomedical application prospects

Inactive Publication Date: 2021-08-27
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor water solubility of baicalein, its bioavailability is low, which limits its clinical application.

Method used

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  • Hyaluronic acid baicalein iron nanoparticles and preparation method thereof
  • Hyaluronic acid baicalein iron nanoparticles and preparation method thereof
  • Hyaluronic acid baicalein iron nanoparticles and preparation method thereof

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Effect test

Embodiment 1

[0021] The present embodiment is the preparation method of hyaluronic acid baicalein iron nanoparticles, comprising the following steps:

[0022] Step (1): Dissolve 30 mg of ferrous ammonium sulfate, 10 mg of sodium hyaluronate and 64 mg of polyvinylpyrrolidone in 6 mL of pure water, and stir at room temperature for 10 min;

[0023] Step (2): Dissolving 10 mg of baicalein in 3 mL of ethanol solution;

[0024] Step (3): Slowly add the solution obtained in step (2) to the solution in step (1), stir at room temperature for 24 hours, centrifuge, add pure water and ultrasonically disperse, then centrifuge, and repeat washing to obtain hyaluronic acid baicalein iron nanoparticles.

Embodiment 2

[0026] The present embodiment is the preparation method of hyaluronic acid baicalein iron nanoparticles, comprising the following steps:

[0027] Step (1): Dissolve 30 mg of ferrous ammonium sulfate, 20 mg of sodium hyaluronate and 64 mg of polyvinylpyrrolidone in 6 mL of pure water, and stir at room temperature for 10 min;

[0028] Step (2): Dissolving 10 mg of baicalein in 3 mL of ethanol solution;

[0029] Step (3): Slowly add the solution obtained in step (2) to the solution in step (1), stir at room temperature for 24 hours, centrifuge, add pure water and ultrasonically disperse, then centrifuge, and repeat washing to obtain hyaluronic acid baicalein iron nanoparticles.

Embodiment 3

[0031] The present embodiment is the preparation method of hyaluronic acid baicalein iron nanoparticles, comprising the following steps:

[0032] Step (1): Dissolve 30 mg of ferrous ammonium sulfate, 30 mg of sodium hyaluronate and 64 mg of polyvinylpyrrolidone in 6 mL of pure water, and stir at room temperature for 10 min;

[0033] Step (2): Dissolving 10 mg of baicalein in 3 mL of ethanol solution;

[0034] Step (3): Slowly add the solution obtained in step (2) to the solution in step (1), stir at room temperature for 24 hours, centrifuge, add pure water and ultrasonically disperse, then centrifuge, and repeat washing to obtain hyaluronic acid baicalein iron nanoparticles.

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Abstract

The invention discloses hyaluronic acid baicalein iron nanoparticles and a preparation method thereof. According to the hyaluronic acid baicalein iron nanoparticles provided by the invention, baicalein is used as a basic raw material, and a one-pot method is adopted to synthesize the novel active targeting photo-thermal nanoparticles with high drug loading capacity and uniform size. An in-vitro photo-thermal experiment proves that the hyaluronic acid baicalein iron nanoparticles have excellent photo-thermal performance. A cell experiment proves that the hyaluronic acid baicalein iron nanoparticles have a remarkable tumor inhibition effect and are expected to be combined with photothermal therapy and chemotherapy to be used for tumor treatment. The hyaluronic acid baicalein iron nanoparticles are simple in process and high in repeatability, do not use toxic organic reagents and surfactants, and have high operability and wide application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to hyaluronic acid baicalein iron nanoparticles and a preparation method thereof. Background technique [0002] Tumor has become a major health problem faced by human beings. The current treatment methods for malignant tumors mainly include surgery, chemotherapy and radiotherapy. Because the three methods all have relatively large side effects and rely solely on chemotherapy drug treatment or surgical resection cannot effectively inhibit tumor metastasis and recurrence, thus limiting the application in medicine. [0003] With the rise of interdisciplinary subjects of science, technology and medicine, phototherapy has become a new type of therapy that has attracted much attention in tumor treatment research. Light therapy includes photodynamic therapy and photothermal therapy. Photothermal therapy can effectively control the time and space of photothermal therapy in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61K47/36A61K47/32A61P35/00B82Y5/00A61K31/352
CPCA61K41/0052A61K31/352A61K9/146A61P35/00B82Y5/00
Inventor 张良珂王天宝
Owner CHONGQING MEDICAL UNIVERSITY
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