Hydrolysis method of polymeric proanthocyanidins and product and application thereof

A technology of high-polymer procyanidin and oligomeric proanthocyanidin is applied in chemical instruments and methods, metal/metal oxide/metal hydroxide catalysts, pharmaceutical formulations, etc. lower problem

Pending Publication Date: 2021-08-31
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large molecular weight of PPC, it is not easy to pass through the biomembrane, and the biological activity is low, so the utilization value is low

Method used

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  • Hydrolysis method of polymeric proanthocyanidins and product and application thereof
  • Hydrolysis method of polymeric proanthocyanidins and product and application thereof
  • Hydrolysis method of polymeric proanthocyanidins and product and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0020] Preparation of Highly Aggregated Proanthocyanidins from Larix Bark

[0021] Extraction method was used to extract the high polyproanthocyanidins from the bark of pine leaf. Weigh 30 g of ground larch bark, add 300 mL of 70% (V / V) ethanol solution, reflux in a water bath at 80°C for 2 h, and collect the filtrate by filtration while it is hot. Add 210mL of 70% (V / V) ethanol solution to the filter residue, reflux extraction in a water bath at 80°C for 1 hour, and filter. The filtrates were combined to obtain an extract. Add petroleum ether (60-90) to the extract at a volume ratio of 1:1 to remove impurities such as resins and gums in the extract to obtain a purified solution. Use a rotary evaporator (45 ± 5) °C to recover the ethanol in the purified solution under reduced pressure, and filter to remove the red insoluble matter to obtain a concentrated solution. An equal volume of ethyl acetate was added to the concentrated solution for a total of 6 extractions. Obtain ...

Embodiment

[0040] Weigh 0.5g polyproanthocyanidins and add 53.6g [BMIM]Cl (about 50mL), heat and dissolve under magnetic stirring at 90°C, after the dissolution is complete, add the mixed material and a certain amount of Pd / C catalyst into the hydrogenolysis reaction kettle , feed hydrogen, set the temperature and stirring speed at 500r / min, after the temperature in the reactor reaches the experimental temperature, turn on the rotor and start stirring, count the time, and start the reaction. After the reaction is finished, the reactant is taken out, the Pd / C solid catalyst is removed by filtration, and the reaction product LHPC is obtained, and the degradation effect of proanthocyanidins is represented by the degradation rate, and the degradation rate is calculated according to formula (2). Put the reaction product into a dialysis bag and dialyze for 72h, wash and dry to separate the degradation product.

[0041]

[0042] in: -Degradation rate

[0043] DP 1 - average degree of pol...

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Abstract

The invention discloses a hydrogenolysis method of polymeric proanthocyanidins as well as a product and application of the polymeric proanthocyanidins. The hydrogenolysis method provided by the invention comprises the step of carrying out hydrogenolysis reaction on polymeric proanthocyanidins in the presence of an ionic liquid and a hydrogenolysis catalyst. According to the method, the proanthocyanidins is subjected to concerted catalytic hydrogenolysis by adopting the ionic liquid, a safe and stable reaction environment is provided for hydrogenolysis of the proanthocyanidins, and the polymerization degree of the obtained oligomeric proanthocyanidins product is more uniform.

Description

technical field [0001] The invention relates to a method for hydrogenolysis of high-polymerization proanthocyanidins and its product and application. Background technique [0002] Larix is ​​the main species of coniferous forest in Greater Khingan Mountains in China, with abundant timber, and it is also an important tree species for future afforestation and forest regeneration in this area. Larch bark is rich in Proanthocyanidins (PC), accounting for 10%-16% of the total bark mass. From the chemical structure point of view, PC is connected by C4-C8 (or C6-C8) "direct bond" C-C bond by catechin (or epicatechin), and the average degree of polymerization of PC in larch bark is 9- 10, the molecular weight is about 2800. PC can be regarded as a flavonoid compound with a monomeric structure of "flavan-3-ol". At the same time, as a main component of larch bark extract, it has the properties of tannins and is widely used in the leather tanning industry. . Previous studies have s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/62B01J23/44A61K8/49A61Q17/04A61Q19/08
CPCC07D311/62B01J23/44A61K8/498A61Q19/08A61Q17/04
Inventor 任世学李淑君周盟陈小霞王雪纯张武敌高崇
Owner NORTHEAST FORESTRY UNIVERSITY
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