Automatic leaching, synthesizing and sub-packaging method of technetium [99mTc] labeled drug
An automatic synthesis and labeling technology, which is applied in the field of synthesis and sub-packaging, and automatic elution of technetium [99mTc]-labeled drugs, can solve the problems that are difficult to comply with the principles of repeatability and stability of drug production, the high risk of radiation for workers, and the inability to Good compliance with GMP production specifications and other issues
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[0042] Technetium [ 99m Tc] methylene diphosphate ( 99m Tc-MDP) as an example, its automatic washing, synthesis and packaging methods are as follows:
[0043] (1) Dissolve the MDP freeze-dried kit with 1ml sodium chloride injection, and place it in the reaction bottle 12 in advance. All the following operations are computer-controlled and automated.
[0044] (2) Valve six 6 is connected to molybdenum-technetium generator 15, valve six 6 is turned right, valve seven 7 is horizontal, valve eight 8 is turned left, the syringe 14 draws about 3ml, and the sodium pertechnetate solution is rinsed into the syringe 14 to complete the automatic Rinsing process.
[0045] (3) Valve eight 8 turn left, valve six 6, valve seven 7 level, valve two 2 turn right, valve three 3 turn left, syringe 14 drops about 3ml, inject sodium pertechnetate solution into reaction bottle 12.
[0046] (4) Labeling synthesis reaction at room temperature for 5 minutes, the reaction volume is about 4ml, and th...
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