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Preparation method of tumor bone cutting edge filler for preventing prosthesis loosening and tumor postoperative recurrence

A stuffer and tumor technology, which is applied in orthopedic implant materials and its preparation, and the implant material and its preparation for prosthesis fixation and inhibition of bone tumor recurrence after surgery, can solve the problems of promoting bone growth at the joint of the prosthesis, Problems such as tumor cells cannot be eliminated, and the effect of reducing the risk of aseptic loosening, solving toxic and side effects, and good implantation safety

Pending Publication Date: 2021-09-10
SUZHOU ORIGIN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The commonly used material for fixing the prosthesis is bone cement, but this material does not promote bone growth at the joint of the prosthesis, nor can it eliminate residual tumor cells

Method used

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  • Preparation method of tumor bone cutting edge filler for preventing prosthesis loosening and tumor postoperative recurrence
  • Preparation method of tumor bone cutting edge filler for preventing prosthesis loosening and tumor postoperative recurrence
  • Preparation method of tumor bone cutting edge filler for preventing prosthesis loosening and tumor postoperative recurrence

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preparation example Construction

[0026] The preparation method of the tumor bone resection filler for preventing prosthesis loosening and postoperative tumor recurrence is as follows: figure 1 As shown, it includes the following production steps:

[0027] (1) produce metal particles containing magnesium, and carry out cleaning treatment;

[0028] (2) Weigh the quality of bone cement powder and metal particles in proportion;

[0029] (3) the mixed powder weighed in step 2 is packed in the packaging bag and carried out independent vacuum packaging, sterilization;

[0030] (4) When in use, add the mixed powder and bone cement liquid together into a sterile vacuum mixing bowl;

[0031] (5) prevent the magnesium particles from being oxidized in the air, and mix the reagents in a vacuum mixer in step 4;

[0032] (6) After stirring for a certain period of time, implant the mixture of bone cement and magnesium particles into the medullary cavity, wait for curing, and fix the prosthesis.

[0033] Specifically, the...

Embodiment 1

[0039] A method for preparing a tumor bone resection filler for preventing prosthetic loosening and tumor postoperative recurrence, said effect on osteosarcoma cell growth comprising the following steps:

[0040] (1) Prepare high-purity magnesium particles with a diameter of 0.26 mm and a length of 1 mm. The prepared magnesium metal particles were ultrasonically cleaned in n-hexane, acetone, 100% ethanol solution and 70% ethanol solution for 10-25 minutes respectively, and then dried at room temperature.

[0041] (2) The cleaned magnesium metal particles are mixed with bone cement powder, and the mass ratio of mixing is bone cement powder: high-purity magnesium particles is 10:1;

[0042] (3) Take by weighing 3.3 grams of mixed powder, pack it into a packaging bag and carry out vacuum packaging, and irradiate under gamma rays for 15 minutes;

[0043] (4) Pour 1.5 ml of bone cement liquid and mixed powder into a sterile vacuum mixing bowl through a needle, and mix in the vacuu...

Embodiment 2

[0054] A method for preparing a tumor bone resection filler for preventing prosthetic loosening and postoperative tumor recurrence, the impact on osteosarcoma cell metastasis comprises the following steps:

[0055] (1) Prepare high-purity magnesium particles with a diameter of 0.26 mm and a length of 1 mm. The prepared magnesium metal particles were ultrasonically cleaned in n-hexane, acetone, 100% ethanol solution and 70% ethanol solution for 10-25 minutes respectively, and then dried at room temperature.

[0056] (2) The cleaned magnesium metal particles are mixed with bone cement powder, and the mass ratio of mixing is bone cement powder: high-purity magnesium particles is 10:1;

[0057] (3) Take by weighing 3.3 grams of mixed powder, pack it into a packaging bag and carry out vacuum packaging, and irradiate under gamma rays for 15 minutes;

[0058] (4) Pour 1.5 ml of bone cement liquid and mixed powder into a sterile vacuum mixing bowl through a needle, and mix in the vac...

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Abstract

The invention provides a preparation method of a tumor bone cutting edge filler for preventing prosthesis loosening and tumor postoperative recurrence. The preparation method comprises the following production steps of: (1) preparing metal particles containing magnesium elements, and carrying out cleaning; (2) respectively weighing the mass of the bone cement powder and the mass of the metal particles at a ratio; (3) loading the mixed powder weighed in the step (2) into a packaging bag for carrying out independent vacuum packaging and disinfection; (4) during utilization, adding the mixed powder and the bone cement liquid into a sterile vacuum mixing bowl; (5) preventing the magnesium particles from being oxidized in air, and mixing the mixed reagent in the step (4) in a vacuum stirrer; and (6) when stirring is carried out for certain time, implanting the mixture of the bone cement and the magnesium particles into the medullary cavity, waiting for solidification, and fixing the prosthesis. By use of the tumor bone edge cutting filler, the risk of secondary surgery is reduced, the postoperative living quality of a patient is greatly improved, manpower and material resources are saved, and the tumor bone edge cutting filler is suitable for being popularized and used.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an orthopedic implant material and a preparation method thereof, in particular to an implant material for fixing a prosthesis and inhibiting postoperative recurrence of bone tumors and a preparation method thereof. Background technique [0002] The traditional method of treating bone tumors is extensive resection of the tumor and its surrounding normal tissues, followed by limb salvage treatment through artificial joint prosthesis replacement. However, studies at home and abroad have shown that aseptic loosening and local recurrence often lead to the failure of artificial joint prosthesis replacement. Therefore, in order to improve the success rate of limb salvage for bone tumors, it is urgent to develop new treatment methods to promote prosthesis-osseointegration, avoid prosthetic loosening, and inhibit tumor recurrence and metastasis. [0003] The commonly used material for f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/88
CPCA61B17/8833A61B17/8805
Inventor 昝睿嵇伟平王文辉倪嘉桦张小农
Owner SUZHOU ORIGIN MEDICAL TECH
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