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Bionic composite hydrogel as well as preparation method and application thereof

A composite hydrogel and hydrogel technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve problems such as complex preparation process, low toughness, and low hydrogel

Active Publication Date: 2021-09-10
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent CN201210054376.1 discloses a method for preparing a biomimetic layered high-strength composite hydrogel film. Although the biomimetic composite hydrogel film obtained by the preparation method can improve the mechanical properties of the composite hydrogel, it is still lower than Natural hydrogel, and the preparation process is more complicated
Moreover, most of the hydrogels currently synthesized have the defect of low toughness

Method used

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  • Bionic composite hydrogel as well as preparation method and application thereof
  • Bionic composite hydrogel as well as preparation method and application thereof
  • Bionic composite hydrogel as well as preparation method and application thereof

Examples

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preparation example Construction

[0034] The invention provides a kind of preparation method of biomimetic composite hydrogel, comprises the following steps:

[0035] (1) Provide composite hydrogel;

[0036] (2) The composite hydrogel obtained in the step (1) is sequentially subjected to confinement drying and swelling in air, and then soaked in a saturated NaCl solution to obtain a biomimetic composite hydrogel.

[0037] The present invention provides composite hydrogels. In the present invention, the composite hydrogel preferably includes PVA / CMC-Fe 3+ Composite hydrogel, or PVA / cellulose derivative-Fe 3+ Double network composite hydrogels. The present invention is to described PVA / CMC-Fe 3+ Double network composite hydrogel or PVA / cellulose derivative-Fe 3+ The preparation method of the double-network composite hydrogel is not particularly limited, and a preparation method well known to those skilled in the art can be used.

[0038] In the present invention, the PVA / CMC-Fe 3+ The preparation method o...

Embodiment 1

[0072] (1) Dissolve 3.4g of PVA in 20mL of deionized water, 0.72g of CMC in 9mL of deionized water, and accelerate the stirring in a heat-collecting magnetic stirring bath at 92°C; after both are completely dissolved, add the CMC solution to into the PVA solution, stirred at 92°C for 20 minutes to make it evenly mixed; added dropwise hydrochloric acid with a volume fraction of 30%, and adjusted the pH of the solution to 2; put the obtained solution in an ice-water bath until the temperature dropped to 0°C, Add 1 mL of 5% glutaraldehyde and stir rapidly to ensure that the solution is well mixed. Pour the obtained solution into a polypropylene mold and place it in a constant temperature water bath at 50°C for 0.5h to form a chemically cross-linked PVA / CMC single network hydrogel, referred to as PVA / CMC-SN hydrogel; among them, CMC and The mass ratio of PVA is 0.21:1;

[0073] (2) PVA / CMC-SN hydrogel in 0.1mol / L Fe(NO 3 )3 9H 2 Soak in O solution for 24 hours. Subsequently, t...

Embodiment 2

[0078] The difference from Example 1 is that the time for the swollen hydrogel in step (3) to be soaked in a saturated NaCl solution is 20 minutes, and the remaining steps are the same as in Example 1 to obtain a biomimetic composite hydrogel, referred to as CDR 100％ -SSN 20 Hydrogels.

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Abstract

The invention provides bionic composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The composite hydrogel is sequentially subjected to confinement drying and swelling, and then is soaked in a saturated NaCl solution, so that the aggregation degree, orientation change and supramolecular interaction strength of molecules in the composite hydrogel can be regulated and controlled, and the mechanical property of the composite hydrogel material is optimal; and the water content and the swelling rate of the bionic composite hydrogel better meet the biochemical performance requirements of a bionic material. The bionic composite hydrogel prepared by the preparation method provided by the invention has high mechanical properties similar to those of natural load-bearing biological tissues; the bionic composite hydrogel is endowed with high toughness due to a special energy dissipation mechanism of a dual-network structure in the bionic composite hydrogel; and the water-containing property and the swelling property are comparable with those of a natural tissue.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a biomimetic composite hydrogel and its preparation method and application. Background technique [0002] Polymer hydrogels are composed of a three-dimensional polymer cross-linked network and a large amount of water, wherein water fills the voids of the three-dimensional polymer cross-linked network, and has both solid (fixed shape) and liquid (water in the interstices of the network) can move freely). Biomimetic composite hydrogel materials with high strength and toughness are a class of biomimetic materials with similar mechanical properties to natural load-bearing biological tissues. In recent years, improving the mechanical properties of composite hydrogels through different strategies has become a research hotspot. [0003] At present, the commonly used method to improve the mechanical properties of biomimetic composite hydrogels is to change the chemical compos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L29/04C08L1/28C08K5/07C08K3/28C08K3/16C08J3/24A61L27/02A61L27/16A61L27/20A61L27/52
CPCC08J3/075C08J3/246A61L27/20A61L27/16A61L27/025A61L27/52C08J2329/04C08J2401/28C08K5/07C08K3/28C08K3/16A61L2430/02C08L29/04C08L1/28
Inventor 王艳芹张雪慧马晓璐王小斌王景辉武晓刚陈维毅
Owner TAIYUAN UNIV OF TECH
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