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Method for synthesizing lauroyl chloride through reaction of lauric acid and phosgene

A technology of lauric acid and lauroyl, which is applied in the field of lauric acid and phosgene reaction to synthesize lauroyl chloride, and can solve the problems of low production capacity, large amount of solid waste, large consumption and the like

Pending Publication Date: 2021-09-14
上海祖玥新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned amine and amide catalysts have the problems of large consumption, low production capacity, and more solid waste generated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the present invention provides a kind of technical scheme: a kind of method of lauric acid and phosgene reaction synthesis lauroyl chloride, comprises the steps:

[0018] Step 1: Adding lauric acid and an organic solvent to the reaction vessel to dissolve and disperse the lauric acid in the organic solvent to obtain solvent A;

[0019] Step 2: add the reaction solvent to the solvent A, and heat the reaction vessel under reflux to raise the temperature to 130° C. and keep it for 5 hours to obtain the solvent B;

[0020] Step 3: feed phosgene into the reaction vessel, and when the mol ratio of lauric acid and phosgene is 1:3, stop the feed of phosgene and drop to room temperature;

[0021] Step 4: Pass an inert gas into the reaction vessel, and distill under reduced pressure to obtain lauroyl chloride.

[0022] In this embodiment, the organic solvent in step 1 is toluene, and the reaction solvent in step 2 is DMAP catalyst.

[0023] In this embodiment, the...

Embodiment 2

[0026] Step 1: Adding lauric acid and an organic solvent to the reaction vessel to dissolve and disperse the lauric acid in the organic solvent to obtain solvent A;

[0027] Step 2: add the reaction solvent to the solvent A, and heat the reaction vessel under reflux to raise the temperature to 110° C. and keep it for 6 hours to obtain the solvent B;

[0028] Step 3: feed phosgene into the reaction vessel, and when the mol ratio of lauric acid and phosgene is 2:5, stop the feed of phosgene and drop to room temperature;

[0029] Step 4: Pass an inert gas into the reaction vessel, and distill under reduced pressure to obtain lauroyl chloride.

Embodiment 3

[0031] Step 1: Adding lauric acid and an organic solvent to the reaction vessel to dissolve and disperse the lauric acid in the organic solvent to obtain solvent A;

[0032] Step 2: add the reaction solvent to the solvent A, and heat the reaction vessel under reflux to raise the temperature to 150° C. and keep it for 3 hours to obtain the solvent B;

[0033] Step 3: feed phosgene into the reaction vessel, and when the mol ratio of lauric acid and phosgene is 1:4, stop the feed of phosgene and drop to room temperature;

[0034] Step 4: Pass an inert gas into the reaction vessel, and distill under reduced pressure to obtain lauroyl chloride.

[0035] The synthesis process of the present invention is simple, and because the whole process process has no other three wastes except the absorbable excess phosgene and carbon dioxide, etc., and the amount of catalyst used is small, it is easy to separate from the product, and it is convenient for recycling. The quality is better, the D...

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PUM

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Abstract

The invention belongs to the field of chemical industry, and particularly discloses a method for synthesizing lauroyl chloride through reaction of lauric acid and phosgene. The method comprises the following steps: adding lauric acid and an organic solvent into a reaction container, and dissolving and dispersing lauric acid into the organic solvent to obtain a solvent A; adding a reaction solvent into the solvent A, refluxing and heating the reaction container to raise the temperature to 110-200 DEG C, and keeping for 2-10 hours to obtain a solvent B; introducing phosgene into the reaction container, stopping introducing the phosgene when the molar ratio of the lauric acid to the phosgene is (1-2): (3-5), and cooling to room temperature; and introducing inert gas into the reaction container, and carrying out reduced pressure distillation to obtain the lauroyl chloride. According to the present invention, the synthesis process flow is simple, no other three wastes are discharged in the whole process except the absorbable excessive phosgene, carbon dioxide and the like, the used catalyst has characteristics of less use amount, easy separation from the product, convenient recycling, excellent product quality, repeated use of the DMAP catalyst, and good synthesis effect.

Description

technical field [0001] The invention relates to the related fields of chemical industry, in particular to a method for synthesizing lauroyl chloride by reacting lauric acid and phosgene. Background technique [0002] Lauroyl chloride is an important organic intermediate, which is widely used in the synthesis of surfactants. The preparation of lauroyl chloride is generally obtained by acyl chlorination of lauric acid through chlorinated reagents such as thionyl chloride and phosphorus trichloride, but due to The acid chlorides obtained by the thionyl chloride method and the phosphorus trichloride method contain sulfur and phosphorus, resulting in residual phosphorus and sulfur in the produced sodium lauroyl amino acid, which affects the application performance of high-end surfactants and cannot meet the high-end market's requirements for product quality. Require. At the same time, phosphorus trichloride as a chlorination reagent will produce a large amount of phosphorus-cont...

Claims

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Application Information

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IPC IPC(8): C07C53/42C07C51/60
CPCC07C51/60C07C53/42
Inventor 王祖玥王磊
Owner 上海祖玥新材料科技有限公司
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