Composition containing pinoresinol diglucoside and preparation method and application of composition

The technology of a kind of pinoresinol diglucoside and composition is applied in the field of composition containing pinoresinol diglucoside and its preparation, which can solve the problems such as side effects unfavorable to health, discount of drug utilization rate, and limited therapeutic effect, so as to improve the body Effects of Immunization, Solubility Promotion and Utilization Improvement

Inactive Publication Date: 2021-09-21
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among the existing methods for treating osteoporosis, most of them have limited curative effects. At the same time, some Chinese herbal medicine formulas have many components, and there are many impurities in them. It will have side effects that are not good for your health

Method used

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  • Composition containing pinoresinol diglucoside and preparation method and application of composition
  • Composition containing pinoresinol diglucoside and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A composition containing pinoresinol diglucoside, in parts by weight, said composition comprises the following components:

[0041] 13 parts of pinoresinol diglucoside, 4 parts of syringaresin, 8 parts of fungus polysaccharide, 3 parts of γ-aminobutyric acid, 5 parts of mannotriose, and 11 parts of bergamotide.

[0042] The preparation method of described fungus polysaccharide is:

[0043] (1) Take the fungus, wash, swell, and homogenate, extract in distilled water at 70°C for 40 minutes, boil and extract for 1.5 hours, and filter to obtain a primary extract and filter residue;

[0044] (2) adding the filter residue to distilled water and ultrasonically extracting for 50min, the power of the ultrasonic wave is 80W, to obtain a secondary extract;

[0045] (3) Combine the primary extract and the secondary extract, add ethanol precipitation after concentrating under reduced pressure; obtain alcohol precipitate;

[0046] (4) Dissolve the alcohol precipitate in water and p...

Embodiment 2

[0050] A composition containing pinoresinol diglucoside, in parts by weight, said composition comprises the following components:

[0051] 10 parts of pinoresinol diglucoside, 1 part of syringaresin, 5 parts of fungus polysaccharide, 1 part of γ-aminobutyric acid, 10 parts of mannotriose, and 15 parts of bergamotide.

[0052] The preparation method of described fungus polysaccharide is:

[0053] (1) Take the fungus, wash, swell, and homogenate, extract in distilled water at 60°C for 60 minutes, boil for 1 hour, and filter to obtain a primary extract and filter residue;

[0054] (2) adding the filter residue to distilled water for ultrasonic extraction for 30min, the power of the ultrasonic wave is 100W, to obtain a secondary extract;

[0055] (3) Combine the primary extract and the secondary extract, add ethanol precipitation after concentrating under reduced pressure; obtain alcohol precipitate;

[0056] (4) Dissolve the alcohol precipitate in water and process it through a s...

Embodiment 3

[0060] A composition containing pinoresinol diglucoside, in parts by weight, said composition comprises the following components:

[0061] 20 parts of pinoresinol diglucoside, 5 parts of syringaresin, 10 parts of fungus polysaccharide, 5 parts of γ-aminobutyric acid, 1 part of mannotriose, and 5 parts of bergamotide.

[0062] The preparation method of described fungus polysaccharide is:

[0063] (1) Take the fungus, wash, swell, and homogenate, extract in distilled water at 80°C for 30 minutes, boil and extract for 2 hours, and filter to obtain a primary extract and filter residue;

[0064] (2) adding the filter residue to distilled water and ultrasonically extracting for 60min, the power of the ultrasonic wave is 80W, to obtain a secondary extract;

[0065] (3) Combine the primary extract and the secondary extract, add ethanol precipitation after concentrating under reduced pressure; obtain alcohol precipitate;

[0066] (4) Dissolve the alcohol precipitate in water and proc...

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a composition containing pinoresinol diglucoside and a preparation method and application of the composition. The composition containing the pinoresinol diglucoside is prepared from the following components: the pinoresinol diglucoside, syringaresinol, agaric polysaccharide, gamma-aminobutyric acid, manninotriose and fingered citron lactone. The composition has a good effect of treating osteoporosis, the preparation method is simple, the toxic and side effects are small, and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a composition containing pinoresinol diglucoside, a preparation method and application thereof. Background technique [0002] Osteoporosis (osteoporosis) is a systemic bone disease in which bone density and bone quality decrease due to various reasons, bone microstructure is destroyed, bone fragility increases, and fractures are prone to occur. Osteoporosis is divided into primary and secondary two categories. Primary osteoporosis is divided into postmenopausal osteoporosis, senile osteoporosis and idiopathic osteoporosis. [0003] There are multiple methods for treating osteoporosis in the prior art. As disclosed in Chinese patent application CN1583069A, a medicine for treating osteoporosis is composed of the following raw materials in parts by weight: 8-12 parts of drynariae, 4-7 parts of Eucommia ulmoides, 4-7 parts of Sangjisheng, and 2-4 parts of d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/7048A61K31/702A61K31/37A61K31/34A61K31/197A61K47/10A61K47/14A61P19/10C08B37/00
CPCA61K31/715A61K31/7048A61K31/702A61K31/37A61K31/34A61K31/197A61K47/10A61K47/14A61P19/10C08B37/0003A61K2300/00
Inventor 肖军平陈梁李小锋刘厚权张梅红胡吉忠夏淑英毛金娣林飞英
Owner JIANGXI POZIN PHARMA
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