Probiotic preparation for preventing and treating osteoporosis, and preparation method thereof

A probiotic preparation and osteoporosis technology, applied in the field of bioengineering, can solve problems such as the inability to ensure the effective utilization of calcium, and achieve the effect of improving absorption and preventing osteoporosis

Active Publication Date: 2015-11-18
山东凤凰生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ingested calcium does not guarantee effective absorption, even if some products add vitamin D, in the case of lack of vitamin K2 in the body, there is no guarantee that the absorbed calcium can be effectively used

Method used

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  • Probiotic preparation for preventing and treating osteoporosis, and preparation method thereof
  • Probiotic preparation for preventing and treating osteoporosis, and preparation method thereof
  • Probiotic preparation for preventing and treating osteoporosis, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of Bacillus natto BLCC1-0053 powder

[0031] Medium formula:

[0032] The mass content of each component in the seed liquid medium is: glucose 0.2%, peptone 1.0%, sodium chloride 0.5%, yeast extract 0.5%, and the rest are distilled water with a pH value of 7.0.

[0033] The mass content of each component in the liquid fermentation medium is: peptone 10%, glycerol 3%, NaCl 0.5%, K 2 HPO 4 0.02%, the rest is distilled water, pH7.0-7.2.

[0034] The cryopreserved Bacillus natto BLCC1-0053 was activated and then transferred to the seed liquid medium, and cultured at 37°C for 16 hours to obtain the seed liquid; with 5% of the inoculum, the seed liquid In the liquid fermentation medium, culture at 37°C and 120rpm for 24h, then transfer to 42°C for 5-7 days of static culture; after the fermentation, immediately centrifuge the fermentation broth and wash it with water at 5000-10000rpm, 5 ~15min, washed 2~3 times, freeze-dried, pulverized, that is, Bacillus n...

Embodiment 2

[0045] In the product compounding step, the mixing ratio of Bacillus natto bacteria powder, Saccharomyces cerevisiae bacteria powder and calcium carbonate is prepared according to the mass ratio of active ingredients, MK-7: VD: Ca 2+ =30:1:160.

[0046] Other steps are the same as in Example 1.

Embodiment 3

[0048] In the product compounding step, the mixing ratio of Bacillus natto bacteria powder, Saccharomyces cerevisiae bacteria powder and calcium carbonate is prepared according to the mass ratio of active ingredients, MK-7: VD: Ca 2+ =300:10:160.

[0049] Other steps are the same as in Example 1.

[0050] Product efficacy verification

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Abstract

The present invention belongs to the technical field of biological engineering, and particularly relates to a probiotic preparation for preventing and treating osteoporosis. The preparation method comprises: carrying out fermentation culture on Bacillus natto to obtain Bacillus natto powder, carrying out Saccharomyces cerevisiae culture and ultraviolet irradiation to obtain Saccharomyces cerevisiae powder, and compounding the Bacillus natto powder, the Saccharomyces cerevisiae powder and calcium carbonate to prepare the probiotic preparation. According to the present invention, the probiotic preparation adopts the natural vitamin K2 (MK-7)-containing probiotic as the raw material, contains vitamin D and calcium, is the safe and green product for preventing and treating osteoporosis, and has effects of calcium absorption improving and osteoporosis prevention and treatment.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and particularly relates to a probiotic preparation for preventing and treating osteoporosis and a preparation method thereof. Background technique [0002] Osteoporosis (OP) is characterized by decreased bone mass and degeneration of bone tissue microarchitecture (thinning of trabecular bone in cancellous bone, reduced number of fractures, porous and thin cortical bone), resulting in increased bone fragility and A systemic bone disorder with an increased risk of fractures. The cause of the disease is generally believed to be related to calcium and vitamin deficiency, endocrine disorders, nutritional disorders, and insufficient exercise and light. The disease is more common in women than men and is more common in postmenopausal women and the elderly. With the increase of the elderly population in my country, the incidence of osteoporosis is on the rise, and it is a health problem worthy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/064A61K35/742A61P19/10A61K33/10A61K31/59
Inventor 单宝龙约克·杰克毕王静任宝涛张颜廷刘虹张化朋王丽春张云静
Owner 山东凤凰生物科技股份有限公司
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