Preparation method and quality detection method of traditional Chinese medicine composition for treating cerebrovascular diseases through meridian rehabilitation method

A cerebrovascular disease and composition technology, applied in the field of medicine, can solve the problems of low extraction efficiency and low product quality stability, and achieve the effects of effective identification, improvement of bioavailability, and elimination of interfering substances

Pending Publication Date: 2021-09-21
乐泰药业有限公司
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  • Description
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  • Application Information

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Problems solved by technology

[0013] The purpose of the present invention is to provide a preparation method and a quality detection method of a traditional Chinese medicine composition for the treatment of cerebrovascular disease by meridian rehabilitation method (abbreviation: Kangluo method), which solves the problems of low extraction efficiency, product quality and stability of existing methods. low sex issues

Method used

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  • Preparation method and quality detection method of traditional Chinese medicine composition for treating cerebrovascular diseases through meridian rehabilitation method
  • Preparation method and quality detection method of traditional Chinese medicine composition for treating cerebrovascular diseases through meridian rehabilitation method
  • Preparation method and quality detection method of traditional Chinese medicine composition for treating cerebrovascular diseases through meridian rehabilitation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The establishment of embodiment 1 extraction process

[0065] 1. Determination of ultrafine pulverization process

[0066] Take the Danshen decoction pieces dried at 80°C for 4 hours for coarse powder and ultrafine pulverization, and take samples at 5min, 15min, 30min, and 45min of ultrafine pulverization, and measure the particle size, water-soluble extract content, and The contents of tanshinone ⅡA and salvianolic acid B are shown in Table 1 below.

[0067] Table 1 Superfine pulverization process experimental results

[0068]

[0069] From the experimental results, it can be seen that with the prolongation of the crushing time, the particle size of the powder gradually decreases, and the magnitude of the reduction becomes smaller and smaller; There was no significant difference in the content of alcohol-soluble extracts of Danshen powder with different particle sizes; there was no significant difference in the content of tanshinone ⅡA in Danshen powder with diffe...

Embodiment 2

[0085] Embodiment 2 Preparation of a Chinese medicine composition for treating cerebrovascular disease by meridian rehabilitation method (abbreviation: Kangluo method)

[0086] Described Chinese medicine composition is prepared by the following steps by the leech of 1250g and the salvia miltiorrhiza of 250g:

[0087] 1. Weighing, drying and crushing: Weigh the Danshen decoction pieces according to the stated weight, dry them at 80°C for 4 hours, and crush them into coarse powder.

[0088] 2. Superfine pulverization, sieving, and mixing: Superfine the salvia miltiorrhiza powder for 30 minutes, sieve it, and mix the sifted salvia miltiorrhiza powder in a mixer for 20 minutes. Packaging, spare.

[0089] 3. Weighing and cutting: Weigh the leech according to the stated weight and cut it into 5-10mm sections.

[0090] 4. Extraction: put the leech into the extraction tank, add water for extraction (90° C.) three times, add 14 times the weight of water for the first time, add 12 tim...

Embodiment 3

[0097] Example 3 Preparation of a traditional Chinese medicine composition for treating cerebrovascular disease by meridian rehabilitation method (abbreviation: Kangluo method)

[0098] Described Chinese medicine composition is prepared by the following steps by the leech of 1500g and the salvia miltiorrhiza of 300g:

[0099] 1. Weighing, drying and pulverizing: Weigh the Danshen decoction pieces according to the stated weight, dry at 75°C for 6 hours, and pulverize into coarse powder.

[0100] 2. Superfine pulverization, sieving, and mixing: superfine the salvia miltiorrhiza powder for 35 minutes, sieve, and mix the sifted salvia miltiorrhiza powder in a mixer for 15 minutes. Packaging, spare.

[0101] 3. Weighing and cutting: Weigh the leech according to the stated weight and cut it into 5-10mm sections.

[0102] 4. Extraction: Put the leech into the extraction tank, add water for extraction (85°C) three times, add 15 times the weight of water for the first time, add 13 ti...

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Abstract

The invention discloses a preparation method and a quality detection method of a traditional Chinese medicine composition for treating cerebrovascular diseases through a meridian rehabilitation method. The steps of filter residue enzymolysis, separation and purification and the like are added on the basis of the original extraction process, so that the defects of the original extraction process are overcome, the loss of bioactive substances is reduced, and the efficacy of the product is improved. A sample is purified by adopting biological pharmaceutical technologies such as ultrafiltration and ion-exchange chromatography, so that the leech extract with high purity and strong biological activity is obtained, and the utilization rate of medicinal materials is improved. The traditional Chinese medicine composition disclosed by the invention is taken as a main material, is supplemented with other products and is combined with a physical therapy of a hyperbaric oxygen chamber, so that the traditional Chinese medicine composition has a very good treatment effect on limb numbness, hemiplegia, facial paralysis, unclear language, water choking and food choking in a recovery period and a sequelae period of cerebrovascular diseases, and has a relatively good curative effect on improving the neurological function of a patient and recovering the action ability; meanwhile, the effect of preventing relapse of cerebrovascular diseases can also be achieved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cerebrovascular disease with meridian rehabilitation method (abbreviation: Kangluo method) and its technology and quality detection method, belonging to the technical field of medicine. Background technique [0002] Stroke is the name of a disease in traditional Chinese medicine, and modern medicine is called stroke or cerebrovascular disease, which refers to a disease of brain damage caused by damage to cerebral blood vessels caused by various reasons. Since the onset and progression of the disease are characteristic of wind, it is analogous to stroke. Among all causes of death, cerebrovascular disease ranks third after malignant tumors and heart disease. [0003] Ischemic stroke is the most common type of cerebrovascular disease (stroke), accounting for 69.6%-70.8% of the affected population. At present, the incidence of cerebrovascular disease is increasing year by ye...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61P25/00G01N30/02G01N30/90G01N30/74G01N30/94G01N30/88G01N21/33A61K35/62
CPCA61K35/62A61K36/537A61P9/10A61P25/00G01N30/02G01N30/90G01N30/74G01N30/94G01N30/88G01N21/33G01N2030/884
Inventor 郎伟君
Owner 乐泰药业有限公司
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