Macromolecular drug delivery mechanism and delivery method thereof

Abstract

The invention relates to a macromolecular drug delivery mechanism and a delivery method thereof. The delivery mechanism comprises a stimulation device, an ultrasonic device, a delivery device and a microneedle device, the stimulation device is electrically connected with the microneedle device, the delivery device is connected to the microneedle device, under the action of the ultrasonic device and the stimulation device, the macromolecular drug in the conveying device enters cranial nerves through the skin around the upper lip of the face and the wing of the nose so that the brain-entering delivery efficiency is improved. In the delivery mechanism, the alternating current is beneficial to promoting the transdermal permeation and nerve transmission effect of the biological macromolecular drug; ultrasonic waves generated by the ultrasonic device have a cavitation effect and a sound hole effect, and reversible open pore channels can be generated on the surface layer of skin and the surface of subcutaneous tissue cells, so that the permeability of drugs is improved, macromolecular drugs are promoted to enter subcutaneous nervous tissues as soon as possible, and brain-entering delivery of the drugs is achieved through the nerve brain-entering channel.

Description

technical field [0001] The present invention relates to a brain drug delivery device, in particular to a biomacromolecule drug brain delivery mechanism and a delivery method thereof. Background technique [0002] The blood-brain barrier is the most important bottleneck for the treatment of central diseases through peripheral administration of drugs into the brain, especially for hormones, peptides, proteins, genes or vaccines for the treatment of brain diseases. At present, drugs break through the blood-brain barrier mainly through structural or dosage form modification. [0003] The permeability of the blood-brain barrier (BBB) ​​is poor, and peripheral administration such as intravenous, intramuscular, subcutaneous and other routes cannot effectively deliver biomacromolecular drugs to the central nervous system (CNS). In addition, with the increase of the peripheral dose of biomacromolecular drugs, the systemic side effects also increase. [0004] The central administrat...

AI Technical Summary

Problems solved by technology

Although the olfactory pathway provides a feasible pathway for biomacromolecular drugs to enter the brain non-invasively, it is found in clinical practice that the application of this route of administration is limited by many factors, such as the skill of administration, drug molecular weight and concentration, etc., especially body position Therefore, the actual concentration of drugs entering the brain is very low, and long-term effects cannot be formed, thus limiting the popularization and application of biomacromolecular drugs entering the brain through the nasal olfactory pathway

In addition, the drug delivery device using the nasal olfactory pathway is likely to cause discomfort to the patient, especially sneezing, which leads to the inability to guarantee the dosage

[0006] At present, a delivery system for efficiently delivering drugs into the brain has not been seen, which overcomes the problem that the drug delivery system in the prior art cannot effectively promote the entry of biomacromolecular drugs into the brain to take effect, and realizes the efficient delivery of biomacromolecular drugs into the brain to play a role Purpose

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