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Composition containing magnolia sieboldii extract and sleep aiding product

A technology of magnolia magnolia and its composition, which is applied in the field of compositions containing magnolia magnolia extract and sleep aid products. Effect

Pending Publication Date: 2021-10-19
HUAANTANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of Tiannv Mulan extract in the field of sleep aid has not been found yet

Method used

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  • Composition containing magnolia sieboldii extract and sleep aiding product
  • Composition containing magnolia sieboldii extract and sleep aiding product
  • Composition containing magnolia sieboldii extract and sleep aiding product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] This embodiment is the preparation of Magnolia leaf essential oil

[0050] This example adopts the preparation method of Example 1 in the application of patent CN 105708760 A Magnolia extract as a bacteriostatic agent to prepare Magnolia leaf essential oil. The specific preparation steps are as follows: take Magnolia leaves and crush them to 20 meshes, and put them in 4 series In the steam distillation reaction kettle, disperse evenly, add a net cover, pass in water vapor, open the condenser, react for 1 hour, collect the extract, separate oil and water, and obtain the essential oil extracted from the leaves of Magnolia magnolia.

Embodiment 2

[0052] This embodiment uses chlorphenylalanine (PCPA) to establish a mouse model of insomnia

[0053] 5-6 week-old male KM mice (30±5g) were fed adaptively for one week before modeling. The p-chlorophenylalanine PCPA suspension is ready-to-use, 600mg PCPA powder is dissolved in 20mL physiological saline containing 1% Tween80, and the prepared concentration is 30mg / mL. Except for the blank control group, the other groups were intraperitoneally injected at a dose of 0.1 mL / 10 g of mouse body weight, and the blank control group was intraperitoneally injected with the same volume of normal saline containing 1% Tween for 2 consecutive days. 26-30h after the end of the last intraperitoneal injection of PCPA, the mice showed behavioral changes (non-stop activities during the day, increased excitability, irritability, disappearance of circadian rhythm, increased water intake and food intake, and significantly reduced sleep time), indicating that The insomnia model was successfully bu...

Embodiment 3

[0055] This embodiment is the preparation of essential oil composition

[0056] Magnolia leaf essential oil, vetiver essential oil, frankincense essential oil, true lavender essential oil, sweet marjoram essential oil and Scots pine essential oil obtained in Example 1 were respectively 8:4:6:5:4:5, 6:2:4: The mass ratios of 3:2:3 and 4:1:2:2:1:2 were mixed to obtain essential oil compositions, which were respectively recorded as test composition 1, test composition 2 and test composition 3.

[0057] Vetiver essential oil, frankincense essential oil, real lavender essential oil, sweet marjoram essential oil and scots pine essential oil were mixed in a mass ratio of 2:4:3:2:3 to obtain an essential oil composition, which was recorded as the control composition.

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PUM

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Abstract

The invention relates to the technical field of plant extracts, in particular to a composition containing magnolia sieboldii extract and a sleep aiding product. The invention discloses a composition. Magnolia sieboldii extract in the composition can cooperate with vetiver essential oil, frankincense essential oil, real lavender essential oil, sweet marjoram essential oil and European pinus densiflora essential oil to further shorten the sleep latency of mice in a pentobarbital sodium induced sleep experiment and prolong the sleep time; the number of mouse brain hippocampal neurons is increased; and the expression quantity of 5HT-1A protein, GABAAR alpha 1 protein and mRNA level in a brain area is improved. The composition has a remarkable sleep aiding effect.

Description

technical field [0001] The invention relates to the technical field of plant extracts, in particular to a composition and a sleep aid product containing the extract of Magnolia japonica. Background technique [0002] With the increasing pressure of life, people's sleep quality cannot be guaranteed, which has seriously affected normal work and study. [0003] At present, the methods for treating insomnia mainly include drug therapy and non-drug therapy. Drug treatment of insomnia is the most effective method, but drug treatment also has side effects such as drug dependence and drug withdrawal reaction. [0004] Non-drug treatments mainly include aromatherapy, etc. The medicinal ingredients used in aromatherapy are mainly plant extracts. Although the therapeutic effect of aromatherapy using plant extracts is not as fast as that of drugs, the advantage is that the plant extracts are pure and safe, and there are almost no side effects such as drug dependence and drug withdrawa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P25/20A61K36/575
CPCA61K36/575A61K36/899A61K36/324A61K36/53A61K36/15A61P25/20A61K8/922A61Q19/00A61K2800/10A61K2800/805A61K2300/00
Inventor 唐明慧宋妮艾勇何廷刚朱思阳张炽坚
Owner HUAANTANG BIOTECH GRP CO LTD
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