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Simethicone microbubble ultrasonic contrast agent as well as preparation method and application thereof

A technology of ultrasound contrast agent and simethicone, which is applied in echo/ultrasound imaging agents, pharmaceutical formulations, preparations for in vivo tests, etc., and can solve the problems of high price and high cost

Pending Publication Date: 2021-10-22
JINAN CENTER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the ultrasonic contrast agents used in clinical practice mainly rely on imports, which are expensive and costly. The development of stable, cheap and reliable ultrasonic contrast agents has become an urgent task in the research of medical and other related technical fields in my country.

Method used

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  • Simethicone microbubble ultrasonic contrast agent as well as preparation method and application thereof
  • Simethicone microbubble ultrasonic contrast agent as well as preparation method and application thereof
  • Simethicone microbubble ultrasonic contrast agent as well as preparation method and application thereof

Examples

Experimental program
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Effect test

no. 1 example

[0040] A preparation method of Simethicone microbubble ultrasound contrast agent, comprising the steps of:

[0041](1) Weigh 1.48g of Span60 and 1.50g of NaCl solid powder on an electronic balance ME 204, then put them into a beaker with a volume of 100ml, extract 5ml of simethicone with a pipette gun, measure 50ml of PBS buffer solution with a measuring cylinder, and add the Magnetic stirring was carried out after putting into the beaker to obtain the premixed solution.

[0042] (2) Put the premixed solution in a pressure cooker, store it under high temperature and high pressure at 121°C for 30 minutes, take it out and put it on a magnetic stirrer to stir the solution again, and bring it to room temperature to obtain a sterilized suspension.

[0043] (3) Prepare one tee tube and two 10ml syringes, one of which draws the sterilized suspension, and the other syringe draws C 3 f 8 gas, and sterile suspension and C 3 f 8 The volume ratio of the gas is 5:1, and then the two sy...

no. 2 example

[0048] A preparation method of Simethicone microbubble ultrasound contrast agent, comprising the steps of:

[0049] (1) Weigh 1.5g of Span60 and 1.0g of NaCl solid powder on an electronic balance ME 204, then put them into a beaker with a volume of 100ml, extract 3ml of simethicone with a pipette gun, measure 50ml of PBS buffer solution in a graduated cylinder, and add the Magnetic stirring was carried out after putting into the beaker to obtain the premixed solution.

[0050] (2) Put the premixed solution in a pressure cooker, store it under high temperature and high pressure at 121°C for 30 minutes, take it out and put it on a magnetic stirrer to stir the solution again, and bring it to room temperature to obtain a sterilized suspension.

[0051] (3) Prepare one tee tube and two 10ml syringes, one of the syringes draws the sterile suspension, the other syringe draws perfluorobutane gas, and the sterile suspension and perfluorobutane gas The volume ratio is 6:1, and then the...

no. 3 example

[0056] A preparation method of Simethicone microbubble ultrasound contrast agent, comprising the steps of:

[0057] (1) Weigh 1.0g of Span60 and 1.2g of NaCl solid powder on an electronic balance ME 204, then put them into a beaker with a volume of 100ml, extract 1ml of simethicone with a pipette gun, measure 50ml of PBS buffer solution in a graduated cylinder, and add the Magnetic stirring was carried out after putting into the beaker to obtain the premixed solution.

[0058] (2) Put the premixed solution in a pressure cooker, store it under high temperature and high pressure at 121°C for 30 minutes, take it out and put it on a magnetic stirrer to stir the solution again, and bring it to room temperature to obtain a sterilized suspension.

[0059] (3) Prepare one tee tube and two 10ml syringes, one of which draws the sterilized suspension, and the other syringe draws SF 6 gas, and sterile suspension and SF 6 The volume ratio of the gas is 4:1, and then the two syringes are ...

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Abstract

The invention relates to the technical field of ultrasonic contrast agents, and particularly discloses a simethicone microbubble ultrasonic contrast agent as well as a preparation method and the application thereof. The contrast agent comprises a shell, inert gas and a buffer solution, wherein the inert gas and the buffer solution are wrapped in the shell, and the shell is made of simethicone. The method comprises the following steps: (1) providing a sterilized suspension formed by sodium chloride, a buffer solution and simethicone; (2) mixing the sterilized suspension with inert gas, and treating by using a right heart acoustic radiography method to obtain a suspension A; and (3) mixing the suspension A with the inert gas again, and carrying out ultrasonication treatment to obtain a suspension B. And (4) standing the suspension B, and taking the middle layer microbubble liquid after layering, thereby obtaining the product. The microbubble ultrasonic contrast agent taking simethicone as a film-forming material has good in-vivo enhanced imaging capability on ultrasound for clinical diagnosis, and is good in biocompatibility, and the preparation process is simple and convenient.

Description

technical field [0001] The invention relates to the technical field of ultrasound contrast agents, in particular to a simethicone microbubble ultrasound contrast agent and its preparation method and application. Background technique [0002] The information disclosed in the Background of the Invention is only intended to increase the understanding of the general background of the invention, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes the prior art that is already known to those skilled in the art. [0003] Ultrasound contrast agents are a class of diagnostic reagents that can significantly enhance ultrasonic scattering signals, and have good application prospects in medical imaging diagnosis. An ideal ultrasound contrast agent can be used as a blood cell tracer and distributed throughout the body with the blood flow to reflect the blood perfusion of organs without interfering with hemodynamics. This bloo...

Claims

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Application Information

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IPC IPC(8): A61K49/22
CPCA61K49/223A61K49/22
Inventor 刘村陈文琪郑艳玲赵璇张倩
Owner JINAN CENTER HOSPITAL