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Preparation method of Xinmaitong capsule

A technology of Xinmaitong and capsules, which is applied in the field of medicine, can solve problems such as short shelf life of capsules, small space for excipients, and influence on curative effect, and achieve the effects of improving product fluidity, increasing production efficiency, and improving product stability

Active Publication Date: 2021-11-05
JIANGXI JIMINKEXIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The amount of extract prepared by the existing method is large, the space for excipients is small, and the shelf life of capsules prepared by conventional wet granulation is short, and it is easy to fail within the validity period, thereby affecting the curative effect

Method used

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  • Preparation method of Xinmaitong capsule
  • Preparation method of Xinmaitong capsule
  • Preparation method of Xinmaitong capsule

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0100] Extraction (the extraction method of the following experimental examples is the same):

[0101] ① Grinding: Grinding 6 parts by weight of Panax notoginseng to obtain a fine powder with a particle size of 80 mesh.

[0102] ② Extraction of Huai Mi: add 100 parts by weight of Huai Mi into boiling water, adjust the pH to 8.5 with milk of lime, decoct twice, filter, combine the filtrates, adjust the pH to 4.0-5.0 with hydrochloric acid, and let stand for 24 hours , filtered the precipitate, dried, and crushed into fine powder.

[0103] ③ Extraction of 185 parts by weight of Angelica sinensis and 125 parts by weight of Uncaria; add 7 times the amount of water to decoct twice, each time for 1 hour, pass through a 200-mesh filter cloth, and the filtrate is concentrated to an appropriate amount. Add ethanol to make the alcohol content 70%, let it stand for 24 hours, take the supernatant and filter, recover ethanol from the filtrate, concentrate to 1.20-1.30.

[0104] 4. the ex...

experiment example 1

[0105]Experimental example 1 (existing process): extract 550, Sophora japonica extract 16, Panax notoginseng powder 5.5, Starch 77.7, Microcrystalline cellulose 55.5 Mix evenly, use wet granulation to make granules, dry, and magnesium stearate 2.5 Total blending; ready-to-package product;

experiment example 2

[0106] Experimental Example 2 (existing process): 220 extracts, 16 extracts of Sophora japonica, 5.5 powder of Panax notoginseng, 77.7 starches, and 55.5 microcrystalline cellulose were mixed evenly, and wet granulation was used to make granules, dried, and mixed with magnesium stearate 2.5 Total blending; ready-to-package product;

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Abstract

The invention relates to a preparation method of a Xinmaitong capsule, which comprises following materials: 550 parts by weight of extract extracted from 185 parts by weight of Chinese angelica, 185 parts by weight of cassia seed, 125 parts by weight of uncaria, 125 parts by weight of achyranthes bidentata, 100 parts by weight of salvia miltiorrhiza, 100 parts by weight of pachyrhizua angulatus, 100 parts by weight of sophora flower bud, 100 parts by weight of pubescent holly root, 100 parts by weight of selfheal and 6 parts by weight of pseudo-ginseng, 16 parts by weight of sophora flower bud extract, 5.5 parts by weight of pseudo-ginseng fine powder, 77.7 parts by weight of starch, 30.5 parts by weight of microcrystalline cellulose and 12.5 parts by weight of silicon dioxide; mixing the raw materials, adding a proper amount of purified water, uniformly mixing, carrying out vacuum belt drying to obtain dry paste (heating temperatures in a first area of 110 DEG C, a second area of 95 DEG C and a third area of 80 DEG C, a track speed of 12HZ and a feeding speed of 12HZ), crushing with 80 meshes, totally mixing with 2.5 parts of magnesium stearate, preparing into capsules, and packaging to obtain the capsules.

Description

technical field [0001] The invention relates to a preparation method of Xinmaitong capsules, in particular to a preparation method in a preparation mode. It belongs to the field of medical technology. [0002] technical background [0003] Cardiovascular and cerebrovascular diseases are collectively referred to as cardiovascular and cerebrovascular diseases, and generally refer to ischemic or hemorrhagic diseases in the heart, brain and systemic tissues caused by high blood pressure and high blood lipids. According to the statistics of relevant departments, about 50% of diabetics are combined with various senile diseases such as hypertension and hyperlipidemia. Cardiovascular and cerebrovascular disease is a common disease that seriously threatens the health of human beings, especially middle-aged and elderly people over 50 years old, with high prevalence, disability and mortality. The number of people who die from cardiovascular and cerebrovascular diseases is as high as 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K36/74A61K47/36A61K47/38A61K47/12A61K47/04A61P9/12A61P3/06
CPCA61K9/1652A61K9/1611A61K9/1617A61K36/232A61K36/482A61K36/74A61K36/21A61K36/537A61K36/488A61K36/489A61K36/185A61K36/536A61K36/258A61P9/12A61P3/06A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 李永虎李义保易斌易耀江胡锐敏肖雄汪平元刘瑾
Owner JIANGXI JIMINKEXIN PHARMA