Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof

A technology of composition and components of traditional Chinese medicine, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of unsatisfactory curative effect, strong drug dependence, and long treatment period.

Active Publication Date: 2021-11-09
黑龙江中医药大学附属第二医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, despite the development and improvement of western medicine, it still cannot change the defect of its single drug target. The existing technology still has limitations such as long treatment cycle, strong drug dependence, large side effects, and unsatisfactory curative effect.

Method used

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  • Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof
  • Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof
  • Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] The preparation of embodiment 1 oral liquid

[0089] Gualou 0.55kg Allium 0.45kg Guizhi 0.25kg

[0090] Danshen 0.35kg Bellflower 0.2kg Chuanxiong 0.25kg

[0091] Citrus aurantium 0.25kg Woody fragrance 0.18kg Magnolia officinalis 0.25kg

[0092] A. Weigh 9 raw medicinal materials of Trichosanthes, Fructus Aurantii, Guizhi, Salvia, Campanulaceae, Rhizoma Chuanxiong, Fructus Aurantii, Woody Fragrance, Magnolia officinalis. Cleanly select Danshen, Platycodon grandiflorum, Chuanxiong, Muxiang and Magnolia officinalis, cut into slices, set aside;

[0093] B. Take the raw medicinal herbs in step A, mix well, add 10 times the amount of water for the first time, decoct for 3 hours, add 8 times the amount of water for the second time, decoct for 2 hours, filter the decoction, and concentrate under reduced pressure to 50- The extract with a relative density of 1.18 at 60°C is reserved;

[0094] C. Add ethanol to the extract obtained in step B to make the alcohol content reac...

Embodiment 2

[0096] The preparation of embodiment 2 oral liquid

[0097] Gualou 0.5kg Allium 0.4kg Guizhi 0.25kg

[0098] Danshen 0.45kg Bellflower 0.25kg Chuanxiong 0.25kg

[0099] Citrus aurantium 0.2kg Woody fragrance 0.15kg Magnolia officinalis 0.2kg

[0100] A. Weigh 9 raw medicinal materials of Trichosanthes, Fructus Aurantii, Guizhi, Salvia, Campanulaceae, Rhizoma Chuanxiong, Fructus Aurantii, Woody Fragrance, Magnolia officinalis. Cleanly select Danshen, Platycodon grandiflorum, Chuanxiong, Muxiang and Magnolia officinalis, cut into slices, set aside;

[0101] B. Take the herbal medicine pieces of raw materials in step A, mix well, add 8 times the amount of water for the first time, decoct for 2.5 hours, add 6 times the amount of water for the second time, decoct for 2 hours, filter the decoction, and concentrate under reduced pressure to 50 The extract with a relative density of 1.15 at -60°C is reserved;

[0102] C. Add ethanol to the extract obtained in step B to make the al...

Embodiment 3

[0104] The preparation of embodiment 3 granules

[0105] Gualou 0.5kg Allium 0.4kg Guizhi 0.25kg

[0106] Danshen 0.4kg Bellflower 0.25kg Chuanxiong 0.25kg

[0107] Citrus aurantium 0.25kg Woody fragrance 0.18kg Magnolia officinalis 0.25kg

[0108] A. Weigh 9 raw medicinal materials of Trichosanthes, Fructus Aurantii, Guizhi, Salvia, Campanulaceae, Rhizoma Chuanxiong, Fructus Aurantii, Woody Fragrance, Magnolia officinalis. Cleanly select Danshen, Platycodon grandiflorum, Chuanxiong, Muxiang and Magnolia officinalis, cut into slices, set aside;

[0109] B. Take the herbal pieces of raw materials in step A, mix well, add 8 times the amount of water for the first time, decoct for 3 hours, add 8 times the amount of water for the second time, decoct for 2 hours, filter the decoction, and concentrate under reduced pressure to 50- The extract with a relative density of 1.12 at 60°C is reserved;

[0110] C. Add ethanol to the extract obtained in step B to make the alcohol content...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composition for treating the chronic heart failure and a preparation method thereof. The traditional Chinese medicine composition is prepared from nine raw medicinal materials including trichosanthes kirilowii maxim, allium macrostemon, cassia twig, salvia miltiorrhiza, platycodon grandiflorum, ligusticum wallichii, fructus aurantii, radix aucklandiae and mangnolia officinalis, has the curative effects of relieving chest stuffiness and removing stasis, removing stasis, promoting the circulation of qi and reducing phlegm, and can effectively treat the chronic heart failure caused by turbid phlegm blocking and qi stagnation in chest. Pharmacodynamic experiment results show that the composition disclosed by the invention can reduce cardiac hypertrophy and pulmonary congestion caused by the heart failure, effectively improve cardiac functions, improve ventricular remodeling, slow down an inflammatory reaction process, reduce adhesion and aggregation of platelets in blood vessels, and relieve pulmonary circulation and systemic circulation resistance so as to take an exact treatment effect on the chronic heart failure.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating chronic heart failure and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Chronic heart failure (CHF) refers to a group of syndromes in which various organic or functional heart diseases impair ventricular filling or ejection ability, and is the terminal stage of the development of various cardiovascular system diseases. Heart failure is a common and frequently-occurring disease in clinical senile diseases. Clinically, there are many factors that induce the disease, such as changes in life rhythm, eating habits and life pressure, as well as primary diseases related to heart failure such as high blood pressure. , coronary heart disease, hyperlipidemia, diabetes, myocardial infarction and other incidence rates, whi...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P9/04
CPCA61K36/428A61K36/8962A61K36/54A61K36/537A61K36/346A61K36/236A61K36/752A61K36/285A61K36/575A61K9/0053A61P9/04A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 蔡国锋蔡国梁庄哲贾坤平刘凯
Owner 黑龙江中医药大学附属第二医院
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