Vaginal mucosa repair composition and preparation method thereof

A technology of composition and mucous membrane, which is applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of poor universality, easy repetition, and unclear curative effect, and achieve good applicability and the effect of reducing inflammatory damage

Pending Publication Date: 2021-11-12

广东圆康再生医学科技开发有限公司

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AI-Extracted Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a vaginal mucosa repair composition and its preparation method, ...

Method used

[0040] Wherein, triethanolamine can adjust the pH value of the system to make carbomer thickening, viscosification, and dissolution to form the composition. It can also play a dual role of cleaning and drain...

Abstract

The invention relates to the technical field of vaginal mucosa repair, and discloses a vaginal mucosa repair composition and a preparation method thereof, which aim at solving the technical problems of easiness in recurrence, unclear treatment effect and poor universality in the female genital tract infection treatment method. The vaginal mucosa repair composition is prepared from the following raw materials of caulis spatholobi extract, radix arnebiae seu lithospermi extract, fructus cnidii extract, rhizoma curcumae extract, carboxymethyl chitosan, gene recombinant human epidermal growth factor, soybean isoflavone, carbomer and triethanolamine. The invention also provides a preparation method of the vaginal mucosa repair composition. The vaginal mucosa repair composition has the advantages that the antibiotics are not contained, so that the repeated attack caused by drug resistance of vaginal mucosa inflammation injury is avoided; by combining the traditional Chinese medicine and western medicine, the applicability is good, and the inflammation injury of the vaginal mucosa is obviously relieved.

Application Domain

Antibacterial agentsOrganic active ingredients +9

Technology Topic

Agrimonia eupatoria extractTriethanolamine +19

Examples

Experimental program(3)
Comparison scheme(4)
Effect test(1)

Example Embodiment

[0026] Embodiment 1: A kind of vaginal mucosa repair composition

[0027] (1) In parts by mass, the vaginal mucosa repair composition consists of the following raw materials:

[0028] 10 parts of Caulis Spatholobus Extract, 10 parts of Comfrey Extract, 12 parts of Cnidium Extract, 15 parts of Curcuma Extract, 20 parts of Carboxymethyl Chitosan, 15 parts of recombinant human epidermal growth factor, 5 parts of soybean isoflavone 6 parts, 6 parts of carbomer, 7 parts of triethanolamine.

[0029] Among them, the pharmacology and efficacy of the traditional Chinese medicines Caulis Spatholobus, Comfrey, Cnidium and Curcuma are as follows:

[0030] Spatholobus suberectus Dunn is the dried cane of Spatholobus suberectus Dunn. It has the effects of invigorating blood and nourishing blood, regulating menstruation and relieving pain, relaxing tendons and activating collaterals. For irregular menstruation, dysmenorrhea, amenorrhea, rheumatic arthralgia, numbness and paralysis, blood deficiency and chlorosis.

[0031] Comfrey is the root of Arnebia euchroma (Royle) Johnst. Nature and flavor are sweet, salty, cold. GUIXIN, Liver Channel. It has the functions of cooling blood, promoting blood circulation, and detoxifying rashes.

[0032] Cnidium monnieri is the dry ripe fruit of Cnidium monnieri (L.) Cuss., an umbelliferous plant. It has the effects of drying dampness and expelling wind, killing parasites and relieving itching, warming kidney and strengthening yang. Commonly used for vulva pruritus, eczema pruritus, damp arthralgia lumbago, kidney deficiency impotence, uterine cold infertility.

[0033] Zedoary is the rhizome of Curcuma aeruginosa Roxb. It has the effects of promoting qi and breaking blood, eliminating accumulation and relieving pain. It is commonly used for blood-qi and heartache, stagnant diet, abdominal distension and pain, amenorrhea due to stagnation of blood, and dysmenorrhea.

[0034] The preparation method of above Chinese medicine extract is:

[0035] Take the above-mentioned traditional Chinese medicinal materials to dry, crush them and pass through a 100-mesh sieve, add 5 times the volume of water to cover the medicinal materials and soak overnight; 200kHz ultrasonic crushing for 2 hours, pass through a 50-mesh sieve, add 3 mg/g cellulase according to the weight of the dried medicinal materials, and adjust the pH to About 5.0, enzymolysis at 50°C for 8h, passing through a 30-mesh sieve, inactivating the enzyme at 95°C for 2h, concentrating into an extract, and drying to obtain a traditional Chinese medicine extract.

[0036] Among them, carboxymethyl chitosan has the biological characteristics of hemostasis, antibacterial, wound healing, cell and tissue regeneration, and has good biocompatibility. Under acidic conditions, carboxymethyl chitosan becomes a kind of cationic bioflocculant, which makes the bacteria cells coagulate, and the polymer chains are adsorbed on the surface of bacteria to form a layer of polymer film, which affects the absorption and absorption of nutrients by bacteria. The selective permeability of the cell membrane can disturb the metabolism of the cells, thereby achieving the effect of sterilization and antibacterial.

[0037] Among them, recombinant human epidermal growth factor has the functions of wound repair and wound healing. Promote the growth of fibroblasts, promote mucosal wound healing, and quickly and efficiently repair wounds.

[0038] Among them, soybean isoflavones are derived from pods of legumes, and as phytoestrogens, they can affect hormone secretion, metabolic biological activity, protein synthesis, and growth factor activity.

[0039] Among them, carbomer is a pharmaceutical excipient, which can increase the viscosity of the liquid, reduce the fluidity, improve the bioadhesion and prolong the residence time of the preparation in the vaginal mucosa injury site to exert a long-term effect. And safe, non-toxic, non-irritating and non-allergic.

[0040] Among them, triethanolamine can adjust the pH value of the system to thicken, thicken and dissolve the carbomer to shape the composition. It can also play a dual role of cleaning and drainage through the principle of osmosis and capillary action, which can increase the blood flow rate of vaginal mucosa, help discharge exudate, stimulate fibroblast proliferation, and increase collagen synthesis.

[0041] (2) The preparation method of the vaginal mucosa repair composition comprises the following steps:

[0042] Take the carbomer, add water at a ratio of 1:100 for the carbomer in parts by weight, stir evenly, add the triethanolamine, and stir while adding to obtain a matrix; extract, comfrey extract, cnidium extract, zedoary extract, carboxymethyl chitosan, recombinant human epidermal growth factor, and soybean isoflavones are added to the matrix under stirring, and the stirring is continued to obtain vaginal mucosa Restorative composition mix gel, pack and serve.

Example Embodiment

[0043] Embodiment 2: A kind of vaginal mucosa repair composition

[0044] The difference from Example 1 is:

[0045] In parts by mass, the vaginal mucosa repair composition consists of the following raw materials:

[0046] 12 parts of Caulis Spatholobus Extract, 13 parts of Comfrey Extract, 11 parts of Cnidium Extract, 10 parts of Curcuma Extract, 18 parts of Carboxymethyl Chitosan, 12 parts of recombinant human epidermal growth factor, 8 parts of soybean isoflavone 8 parts, 8 parts of carbomer, 8 parts of triethanolamine.

Example Embodiment

[0047] Embodiment 3: A kind of vaginal mucosa repair composition

[0048] The difference from Example 1 is:

[0049]In parts by mass, the vaginal mucosa repair composition consists of the following raw materials:

[0050] 15 parts of Caulis Spatholobus Extract, 10 parts of Comfrey Extract, 10 parts of Cnidium Extract, 10 parts of Curcuma Extract, 15 parts of Carboxymethyl Chitosan, 15 parts of Gene Recombinant Human Epidermal Growth Factor, 10 parts of Soybean Isoflavone 7 parts, 7 parts of carbomer, 8 parts of triethanolamine.

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Classification and recommendation of technical efficacy words

Good applicability

Vaginal mucosa repair composition and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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