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High-adhesion pain-relieving hydrogel patch and preparation method thereof

A hydrogel paste, high adhesion technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, polymer compounds with non-effective ingredients, etc., can solve the side effects of patient parts, limit the bioavailability of drugs and other problems, and achieve Improves the effect of poor adhesion and significant pain relief

Pending Publication Date: 2021-11-19
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the large number of pain patients, effective pain treatment is necessary. Although many types of pharmaceutical preparations can be released to the patient site through the adhesive effect of compresses, this adhesive effect only brings the drug closer to the target site. However, the drug does not completely adhere to the site, thus limiting the bioavailability of the immobilized drug
On the other hand, the adhesive effect of this application is often dependent on the surface adhesive coating, and this sealing coating often causes side effects on the patient site

Method used

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  • High-adhesion pain-relieving hydrogel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Preparation of lidocaine-loaded polydopamine-doped polyacrylamide hydrogel

[0051] 1) Preparation of polydopamine-doped polyacrylamide hydrogel: Mix 2 ml of acrylamide, 0.05 g of N,N-methylenebisacrylamide and 0.05 g of ammonium peroxide in ice water, and then mix the above The good prepolymer is transferred to a water bath at 37°C, and a polydopamine-doped polyacrylamide hydrogel with high adhesion performance can be obtained after 2 hours;

[0052] 2) Loading of lidocaine drug molecules: After washing the hydrogel obtained above with water for 3 times, pipette 0.1 ml of lidocaine hydrochloride solution with a mass fraction of 20% with a pipette gun, and evenly drop-coat it on the polyacrylamide The surface of the hydrogel is cooled to a ventilated place, and after the liquid gradually penetrates into the colloid, a lidocaine-loaded polydopamine-doped polyacrylamide hydrogel is obtained.

Embodiment 2

[0054] Preparation of polydopamine-doped polyacrylamide hydrogels loaded with bupivacaine and silk fibroin

[0055] 1) Prepolymerization of silk fibroin and dopamine: Take 5 ml of 10% silk fibroin aqueous solution and 10 mg of dopamine hydrochloride and mix them under magnetic stirring at 50 rpm for 24 hours until the solution turns from clear to dark brown.

[0056] 2) Preparation of polydopamine-doped polyacrylamide hydrogel added with silk fibroin: take 1 ml of the above prepolymer solution, 2 ml of acrylamide, 0.05 g of N,N-methylenebisacrylamide and 0.05 g of supernatant Ammonium oxide was uniformly mixed in ice water, and then the above-mentioned mixed prepolymer was transferred to a water bath at 37°C. After 2 hours, a polydopamine-doped polyacrylamide hydrogel with high adhesion was obtained;

[0057] 3) Loading of bupivacaine drug molecules: After the hydrogel obtained above was washed with water for 3 times, 0.1 ml of bupivacaine hydrochloride solution with a mass frac...

Embodiment 3

[0059] Preparation of Polydopamine-doped Polyacrylamide Hydrogels Added with Morphine-Loaded Clay Molecules

[0060] 1) Prepolymerization of clay molecules and dopamine: Take 5 ml of 10% aqueous solution of clay molecules and 10 mg of dopamine hydrochloride and mix them under magnetic stirring at 50 rpm for 24 hours until the solution turns from clear to dark brown.

[0061] 2) Preparation of polydopamine-doped polyacrylamide hydrogel added with clay molecules: take 1 ml of the above prepolymer solution, 2 ml of acrylamide, 0.05 ml of N,N-methylenebisacrylamide and 0.05 g of peroxide Ammonium was uniformly mixed in ice water, and then the above mixed prepolymer was transferred to a water bath at 50°C. After 1 hour, a polydopamine-doped polyacrylamide hydrogel with high adhesion was obtained;

[0062] 3) Loading of morphine drug molecules: the hydrogel obtained above was washed with water for 3 times to obtain a hydrogel with morphine molecular imprinting, and 0.1 ml of morphin...

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Abstract

The invention provides a high-adhesion pain-relieving hydrogel patch and a preparation method thereof. The preparation method comprises the following steps: mixing an acrylamide aqueous solution, dopamine, an additive and a cross-linking agent; after uniformly mixing, adding an initiator at a preset temperature, and obtaining polyacrylamide hydrogel after a preset time; wherein the value range of the preset temperature is 30-70 DEG C; and the value range of the preset time is 0.5 to 3 hours. The analgesic drug molecules are loaded to the polyacrylamide hydrogel, and the high-adhesion pain-relieving hydrogel patch is obtained. The hydrogel patch has natural adhesiveness and antibacterial property, the loaded analgesic drug endows the hydrogel patch with excellent analgesic performance, and the hydrogel patch is simple in preparation method and wide in applicability.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a high-adhesion pain-relieving hydrogel patch and a preparation method thereof. Background technique [0002] Pain is one of the most common clinical symptoms. There are more and more pain patients in my country, including cancer pain, bone and joint degenerative diseases, and neuromuscular diseases. In the sample, the incidence rate of pain was 12%, among the 30-40 age group, the patients accounted for 59.1%; among the 50-60 age group, the patients accounted for 81%, and the pain incidence rate was as high as 82% among the people over 60 years old. If the population of the city is 1 million and the incidence rate is 12% as an example, then the number of patients is 120,000. If in an aging dense city, among the population of 1 million, the population aged 50-60 is assumed to be 400,000. According to the Chinese Medical Disease Prevention and Control According to the survey and ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/167A61K31/445A61K31/485A61K47/32A61K47/34A61K47/36A61K47/42A61P23/02A61P25/04
CPCA61K31/167A61K31/445A61K31/485A61K9/06A61K9/0014A61K47/32A61K47/34A61K47/42A61K47/36A61P25/04A61P23/02
Inventor 刘盼苗杨建军
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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