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Implant and preparation method and application thereof

A technology of implants and mixtures, applied in the field of implants, can solve problems such as repeated infections, infection lesions that cannot be eradicated, and little effect

Active Publication Date: 2021-11-19
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a variety of antibiotics and antibacterial drugs can theoretically be used to combat implant-related infections, bacteria can form dense biofilms on the surface of implants, and biofilms can block the action of drugs (including antibiotics, antibacterial drugs, etc.) effect, which in turn leads to the inability to eradicate the infected lesions, resulting in repeated infections
[0003] In the past few decades, researchers have used various methods to combat biofilms, such as the combination of multiple antibiotics, such as combining drugs that target the mechanism of biofilm formation, and for example, drug delivery through the circulatory system or on the surface of implants. Drug release coating or heavy metal coating; but the above methods have little effect due to the strong resistance of bacteria in the biofilm

Method used

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  • Implant and preparation method and application thereof
  • Implant and preparation method and application thereof
  • Implant and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0098] This embodiment has prepared a kind of implant, and specific process is:

[0099] D1. Polish and ultrasonically clean the titanium-based raw material. After that, place the titanium-based raw material in deionized water, ultrasonically clean it for 5 minutes, repeat three times, and dry it;

[0100] D2. Alkali etching is carried out on the titanium-based raw material obtained in step D1. The etching solution contains 4mol / L potassium hydroxide; the reaction condition is 70°C; the reaction time is 3h; For deionized water, repeat three times to obtain a titanium-based matrix;

[0101] D3. Get curcumin and disperse it in deionized water to make 300 μ g / mL curcumin suspension, adjust the pH of the suspension to be 9, place the above-mentioned suspension on a magnetic stirrer and stir at a constant speed for 24h to make curcumin nanoparticles. DLS (dynamic scattering) and TEM record its particle size as 150 ± 30nm (particle size distribution within this range);

[0102] D4...

Embodiment 2

[0106] This embodiment has prepared a kind of implant, and specific process is:

[0107]D1. Polish and ultrasonically clean the titanium-based raw materials; after that, place the titanium-based raw materials in deionized water, ultrasonically clean for 5 minutes, repeat three times, and dry;

[0108] D2. Alkaline etching is carried out on the titanium-based raw material obtained in step D1. The etching solution contains potassium hydroxide of 10 mol / L; the reaction condition is 70°C; the reaction time is 3h; For deionized water, repeat three times to obtain a titanium-based matrix;

[0109] D3. Get curcumin and disperse it in deionized water to make 600 μ g / mL curcumin suspension, adjust the pH of the suspension to be 8, place the above suspension on a magnetic stirrer and stir at a constant speed for 24h to make curcumin nanoparticles. DLS (dynamic scattering) and TEM record its particle size as 650 ± 50nm (particle size distribution within this range);

[0110] D4. Take t...

Embodiment 3

[0114] This embodiment has prepared a kind of implant, and specific process is:

[0115] D1. Polish and ultrasonically clean the titanium-based raw materials; after that, place the titanium-based raw materials in deionized water, ultrasonically clean for 5 minutes, repeat three times, and dry;

[0116] D2. Alkaline etching is carried out on the titanium-based raw material obtained in step D1. The etching solution contains potassium hydroxide of 10 mol / L; the reaction condition is 70°C; the reaction time is 3h; For deionized water, repeat three times to obtain a titanium-based matrix;

[0117] D3. Get curcumin and disperse it in deionized water to make a curcumin suspension of 50 μg / mL, adjust the pH of the suspension to be 7, place the above-mentioned suspension on a magnetic stirrer and stir at a constant speed for 24h to make curcumin nanoparticles. DLS (dynamic scattering) and TEM record its particle size as 60 ± 5nm (particle size distribution within this range);

[0118...

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Abstract

The invention discloses an implant as well as a preparation method and application thereof. The implant comprises: a titanium-based substrate; an intermediate coating, which coats the surface of the titanium-based substrate and comprise arginine and polydopamine; and a sound-sensitive coating, which coats the surface of the intermediate coating and comprises a binder and a sound-sensitive particle, wherein the sound-sensitive particle has a core-shell structure, a core contains a curcumin particle, and a shell contains polydopamine. According to the implant disclosed by the invention, due to the matching of all the components, the problem of formation of a stubborn biological membrane by bacteria on the surface of the implant can be solved.

Description

technical field [0001] The invention belongs to the technical field of implants, and in particular relates to an implant and its preparation method and application. Background technique [0002] With the advancement of medicine, more and more implants are used clinically, but the infection related to implants is still a key problem that plagues implant surgery. Although a variety of antibiotics and antibacterial drugs can theoretically be used to combat implant-related infections, because bacteria can form dense biofilms on the surface of implants, biofilms will block the action of drugs (including antibiotics, antibacterial drugs, etc.) The role, which in turn leads to the inability to eradicate the infected lesion, leading to repeated infection. [0003] In the past few decades, researchers have used various methods to combat biofilms, such as the combination of multiple antibiotics, such as combining drugs that target the mechanism of biofilm formation, and for example, ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/02A61L31/16
CPCA61L31/022A61L31/10A61L31/16A61L2300/216A61L2300/624A61L2300/606A61L2300/404C08L79/04
Inventor 侯鸿浩于博蔺汝荣颜冰陈彦
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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