Fixing device for living animal imaging

A technology of in vivo imaging and fixing devices, which is applied in the fields of medical science, diagnosis, diagnostic recording/measurement, etc., can solve problems such as inability to achieve long-term imaging, animals cannot continue to survive, and image instability, and achieve long-term stable imaging and weight Light, good for healing effect

Active Publication Date: 2021-11-23
NAT INST OF BIOLOGICAL SCI BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the imaging device can only be used for short-term imaging (less than 12 hours), and the animal cannot continue to survive after the imaging is completed, and it is impossible to perform long-term imaging of the same cell or tissue for several days or weeks
In addition, the device can only draw air in one direction to immobilize tissues and organs, so high pressure is required to immobilize the imaged tissues and organs
In the imaging of tissues and organs with large range of motion, such as the lung, image instability and tissue damage caused by large negative pressure are prone to occur

Method used

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  • Fixing device for living animal imaging
  • Fixing device for living animal imaging
  • Fixing device for living animal imaging

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as Figure 2 to Figure 4 As shown, the first embodiment of the present invention provides a fixed device for live animal imaging, which includes: a hollow base 1 , an exhaust tube 2 and a cover glass. The upper part of the base 1 is a cylinder 11, and the lower part is a circular platform 12. The base 1 is provided with a cylindrical cavity 13 , a circular groove 14 and a truncated conical cavity 15 in sequence from its top surface to its bottom surface. The narrow end surface of the conical cavity 15 is in contact with the circular groove 14 . The top surface of the cylinder 11 is provided with an upper side edge 16 protruding radially from the side wall of the base 1 . A plurality of fixing holes 161 are disposed on the upper edge 16 . An air extraction pipe 2 is arranged on the side wall of the base 1, and the inside of the air extraction pipe 2 is provided with a cylindrical air extraction channel 21, which communicates with the circular groove 14 in the bas...

Embodiment 2

[0037] Such as Figure 5 to Figure 8As shown, another animal imaging fixation device provided in Embodiment 2 of the present invention. Parts in this embodiment that have the same structure as the animal live imaging and fixing device described in Embodiment 1 will not be described again. In the imaging fixing device of this embodiment, two exhaust pipes 2 distributed at 180° are arranged on the side wall of the base 1 . The number of air extraction pipes 2 and the way the air extraction pipes 2 are distributed on the side wall of the base 1 can be determined according to needs, evenly distributed or non-uniformly distributed, which is not specifically limited in the embodiment of the present invention. When using the imaging fixation device of this embodiment, the two suction tubes 6 work independently or simultaneously as required to fix the imaging tissue. The air suction port end 22 of the air extraction pipe 2 is conical, so that the hose used for air extraction is more...

Embodiment 3

[0039] Such as Figure 9 to Figure 11 As shown, there is yet another fixed device for live animal imaging provided by Embodiment 3 of the present invention. The imaging fixing device of this embodiment is provided with four exhaust pipes 2 distributed at 90° on the side wall of the base 1 of the imaging fixing device described in the first embodiment. The suction port end 22 of the suction pipe 2 is conical, and a groove 22 is arranged on the outer wall of the suction pipe 2 . During the imaging process, the four air extraction tubes 2 can work individually or in different combinations according to experimental needs to perform fixed imaging on animal tissues or organs. This structure is suitable for organs and tissues with large range of motion under physiological conditions, such as lungs and hearts. The number of air extraction pipes 2 and the way the air extraction pipes 2 are distributed on the side wall of the base 1 can be determined according to needs, evenly distrib...

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Abstract

The invention discloses a fixing device for living animal imaging, which comprises a hollow base, an exhaust pipe arranged on the side wall of the base and a cover glass. The upper part of the base is a cylinder, and the lower part is a round table; a cylindrical cavity, a circular groove and a circular-truncated-cone-shaped cavity which are communicated in sequence are formed in the base; the top face and the bottom face of the base are provided with an upper side edge and a lower side edge respectively. The fixing device is small in size and light in weight, and can be directly mounted on an animal body. The upper side edge covers the skin at the surgical incision of the animal, so that the wound is protected. Therefore, long-time stable imaging of the same cell, tissue and organ of an animal is realized, direct observation of vital activities of the tissue and organ is realized, and overall observation of injury and recovery processes is realized.

Description

technical field [0001] The invention relates to the technical field of biological imaging, in particular to an imaging fixation device for living animals. Background technique [0002] In vivo imaging experiments for the purpose of observing the complete process of tissue damage and regeneration require the use of in vivo imaging fixtures. An existing living body imaging fixation device is an imaging device with a handle, such as figure 1 As shown, the upper part of the imaging device is a cylindrical hollow cylinder. When working, the cover glass is placed on the bottom boss of the hollow cylinder and sealed. There is a hollow suction tube connected to the groove inside the imaging device. middle. The lower part of the imaging device is a protruding frustum-shaped cavity, the upper side of the cavity is in contact with the cover glass and communicates with the groove 3 inside the imaging device, and then the device is pressed on the animal's body through the handle to exp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0077A61B5/6847A61B2503/40A61B2503/42Y02A40/70
Inventor 李蛟汤楠
Owner NAT INST OF BIOLOGICAL SCI BEIJING
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