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Preparation and ultraviolet protection application of artificial fungus melanin material

A technology of melanin and melanin precursor, which is applied in the field of melanin materials, can solve the problems of uneven morphology of fungal melanin materials, unfavorable large-scale use, complex enzyme production process, etc., achieve good UV absorption ability, facilitate recycling, and reduce costs low effect

Active Publication Date: 2021-11-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when using enzymes to synthesize fungal melanin under artificial conditions, because there are not as many regulatory mechanisms as in organisms, most of the synthesized fungal melanin materials have uneven shapes
And the enzyme activity is affected by many factors, making the reproducibility poor
More importantly, the production process of enzymes is complicated and expensive, which is not conducive to large-scale use

Method used

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  • Preparation and ultraviolet protection application of artificial fungus melanin material
  • Preparation and ultraviolet protection application of artificial fungus melanin material
  • Preparation and ultraviolet protection application of artificial fungus melanin material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A preparation method of artificial fungal melanin nanoparticles, comprising the following steps:

[0052] Under air atmosphere, dissolve 150 mg of melanin precursor 1,8-dihydroxynaphthalene in a solvent of acetonitrile and water, including 15 mL of acetonitrile and 135 mL of deionized water, adjust the pH value to 3-4 with dilute hydrochloric acid, and stir for about 10 A solution was obtained in 1 minute. At this time, the concentration of 1,8-dihydroxynaphthalene was about 1 mg / mL.

[0053] Dissolve copper compound catalyst copper sulfate pentahydrate in water to prepare 1mol / L B solution.

[0054] Heat solution A on a metal bath to 50°C under stirring, add 75 μL of solution B into A under stirring, and mix well. hours to obtain a reaction solution.

[0055] The reaction solution was centrifuged in a centrifuge at a speed of 12,000 rpm for 5 minutes, the precipitate was washed with deionized water, ultrasonically dispersed, and then centrifuged again, and repeated t...

Embodiment 2 to Embodiment 10

[0058] Embodiment 2 to embodiment 10 are basically the same as embodiment 1, the difference lies in the ratio of 1,8-dihydroxynaphthalene and copper sulfate, as well as temperature and reaction time, see the following table for details.

[0059]

Embodiment 11 to Embodiment 12

[0061] Copper ions play a catalytic role in soluble copper salts, and its acid radical ions have little effect on the reaction. Most soluble copper salts have similar effects, and some insoluble copper compounds can also achieve similar effects.

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Abstract

A preparation method of artificial fungus melanin nanoparticles comprises the following steps: dissolving a melanin precursor in a solvent in an air atmosphere, adjusting the pH value to 3-4, and stirring to obtain a solution A; dissolving a copper compound catalyst in water to prepare a solution B; heating the solution A in a metal bath while stirring, adding the solution B into the solution A while stirring, uniformly mixing, and reacting to obtain a reaction solution; centrifuging the reaction solution, washing a precipitate, ultrasonically dispersing, centrifuging again, and repeating the above for multiple times to obtain the artificial fungus melanin nano particles; and dispersing and storing the artificial fungus melanin nanoparticles in deionized water. The method has the advantages of few side reactions, low cost, high yield, simple operation, short process flow and high repeatability. The particle size of the nano particles can be regulated and controlled by adjusting the reaction conditions and the raw material ratio, and the particle size ranges from 60 nm to 700 nm. The obtained nanoparticles have high ultraviolet absorption capability which is obviously stronger than that of a polydopamine material used in the field of ultraviolet protection, and are expected to be used as a new ultraviolet protection additive.

Description

technical field [0001] The invention relates to the preparation of an artificial fungal melanin material and its application in ultraviolet protection, in particular to a fungal melanin nanoparticle, its preparation method and its application in ultraviolet protection, belonging to the technical field of melanin materials. Background technique [0002] Melanin, a natural pigment present in many organisms such as animals, plants, and microorganisms, is best known for its role in the coloring of human skin, however, they also function in a variety of ways, such as metal ion complexation, free Radical quenching, photoprotection, neuroprotection, etc. Melanin can be divided into five types according to its structure: eumelanin, pheomelanin, neuromelanin, pyomelanin, and isomelanin. Among them, isomelanin is a kind of nitrogen-free melanin, which usually exists in plants, fungi and other organisms. [0003] The fungal melanin (or DHN-melanin) synthesized with 1,8-dihydroxynapht...

Claims

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Application Information

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IPC IPC(8): C08G65/44C08L29/04C08L71/10C08J5/18
CPCC08G65/44C08J5/18C08J2329/04C08J2471/10C08L2201/08
Inventor 李乙文黄楚皓
Owner SICHUAN UNIV
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