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Quality detection method of traditional Chinese medicine compound preparation and application of quality detection method

A quality inspection method and compound preparation technology, which can be used in measuring devices, instruments, scientific instruments, etc., can solve the problems of traceability analysis of raw materials in Weidonghuoxue Cream, no content measurement items, etc., and achieve strong representation, wide coverage, Highly reproducible effect

Inactive Publication Date: 2021-11-26
SHANDONG MINGREN FURUIDA PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the quality standard of Dongfang Huoxue Gao only includes the identification test of borneol and dried blood, and there is no content determination item, and there is no traceability analysis of the origin of the raw materials in Dongfang Huoxue Gao

Method used

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  • Quality detection method of traditional Chinese medicine compound preparation and application of quality detection method
  • Quality detection method of traditional Chinese medicine compound preparation and application of quality detection method
  • Quality detection method of traditional Chinese medicine compound preparation and application of quality detection method

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Experimental program
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Effect test

preparation example Construction

[0021] (1) Preparation of the test solution: Take Dongfang Huoxue Plaster, extract and purify the polysaccharides in it, dilute the obtained polysaccharides with ultrapure water, filter with a microporous membrane, and take the filtrate as the test product solution;

[0022] (2) Preparation of mixed reference substance solution: Precisely weigh 5 kinds of reference substances including glucose, galactose, arabinose, mannose, and rhamnose, and add ultrapure water to prepare a mixed reference substance solution;

[0023] (3) Determination: Precisely measure the test solution prepared in step (1) and the reference solution prepared in step (2), respectively, and perform detection based on HPLC.

[0024] Take Dongfang Huoxue ointment, add petroleum ether to reflux to remove lipids; dry the filter residue, add ultrapure water and use steam to distill, condense the filtrate, add a mixed solution of chloroform and n-butanol to remove the protein, concentrate and add anhydrous Carry ...

Embodiment 1

[0040] (1) Preparation of reference solution: Weigh the appropriate amount of glucose, galactose, arabinose, mannose, and rhamnose, weigh them accurately, add ultrapure water to make a solution containing 320 μg ferulic acid per 1 ml, As a reference solution;

[0041](2) Preparation of the test solution: Accurately weigh the same batch of Dongfang Huoxue Plaster without the cloth lining, add petroleum ether and reflux for 2.5 h at 90°C to remove lipids, and reflux for 3 times; filter and dry the filter residue and add ultrapure water Use water vapor to carry out distillation, distill 3 times, each 5 hours, after the filtrate is condensed, add the mixed solution that volume ratio is 4:1 chloroform and n-butanol to remove protein wherein, the operation of removing protein is carried out repeatedly, until no As far as the protein is concerned, after concentration, add absolute ethanol to carry out alcohol precipitation, and obtain Chuanxiong polysaccharide after washing; transfer...

Embodiment 2

[0051] Another batch of Dongfang Huoxue Plaster was selected for testing, and the experimental results are shown in Table 2.

[0052] The determination result of carbohydrate in the sample of table 2 ( n =5)

[0053]

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Abstract

The invention provides a quality detection method plaster for promoting blood circulation to remove blood stasis, and application of the quality detection method, belonging to the technical field of quality evaluation. Research finds that the contents of specific polysaccharide compounds contained in traditional Chinese medicine components in oriental blood-activating ointment and from different producing areas are obviously different; with ligusticum wallichii produced in Dujiangyan, Sichuan Province, China and ligusticum wallichii produced in Jiangxi Province, China as examples, the polysaccharide compounds in the ligusticum wallichii produced in Dujiangyan, Sichuan Province, China are mainly composed of glucose and galactose, and the polysaccharide compounds in ligusticum wallichii produced Jiangxi Province, China mainly comprise glucose and arabinose; and thus, the production place of the raw materials of the oriental blood-activating ointment can be controlled by detecting the polysaccharide compounds. Therefore, the method has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of quality evaluation, and in particular relates to a quality detection method of a traditional Chinese medicine compound preparation. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Dongfang Huoxue Ointment is composed of 36 traditional Chinese medicines such as Shengchuanwu, Shengcaowu, safflower, Chuanxiong, Yuanhu, frankincense (made), myrrh (made), Achyranthes bidentata, Qianghuo, Duhuo, and pangolin (made). It is listed in Volume 16 of the Ministry of Health's Drug Standards for Traditional Chinese Medicine Prescriptions. It has the effects of expelling wind and cold, promoting blood circulation an...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/02
CPCG01N30/06G01N30/02
Inventor 江玉娟毋立华陈俊亮高超孙桂雪郝洪慧龙玉波张亚欣
Owner SHANDONG MINGREN FURUIDA PHARMA