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Process for preparing alpha-calcium phosphate as basic material of bone reparing biological material

A biomaterial, calcium phosphate technology, applied in chemical instruments and methods, phosphorus compounds, medical science, etc., can solve the problem of expensive α-TCP

Inactive Publication Date: 2004-02-04
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the preparation process of bone repair matrix material α-TCP is basically the same, and there has been no breakthrough, so α-TCP is expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Accurately weigh 171.1 grams of calcium hydrogen phosphate dihydrate (CaHPO 4 2H 2 O) and 50.0 grams of calcium carbonate (CaCO 3 ), adding 1.4 g of CaF 2 and 0.8 gram of KF composite mineralizer, this mixture is put into the ball mill jar, and the grinding medium and medium are respectively zirconia balls and dehydrated alcohol, material: ball: medium weight ratio is 1: 2: 1.7, ball milling for 4 hours Finally, dry at 80°C, sieve the dried powder, calcinate at 1300°C, and keep it warm for 2 hours, and then naturally cool to room temperature with the furnace to obtain α-TCP material with a purity of 99.2%. The prepared α-TCP material was ground and sealed for use. Example 2:

Embodiment 2

[0009] Accurately weigh 342.2 grams of calcium hydrogen phosphate dihydrate (CaHPO 4 2H 2 O) and 100 grams of calcium carbonate (CaCO 2 ), adding 2.0 g of CaF 2 and 1.8 grams of NaF composite mineralizer, this mixture is put into the ball mill jar, and the grinding medium and the medium are respectively agate balls and absolute ethanol, and the material: ball: medium weight ratio is 1: 3: 1.7, after ball milling for 8 hours , dried at 80°C, sieved the dried powder, calcined at 1420°C, and kept warm for 2 hours, then naturally cooled to room temperature with the furnace to obtain α-TCP material with a purity of 99.2%. The α-TCP material was ground and stored for later use.

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Abstract

An alpha-calcium phosphate as the basic material of bone-repairing biologic material is prepared from calcium phosphate and calcium carbonate through proportional mixing, adding compound mineralizing agent, wet grinding, drying, sieving, high-temp calcining, and naturally cooling. Said mineralizing agent is the fluoric alkali-earth metal salts or alkali metal salts (potassium fluoride or calcium fluoride). Its advantages include high purity and better biologic compatibility and mechanical performance.

Description

technical field [0001] The invention relates to a preparation method of α-calcium phosphate base material of bone repair biological material, which belongs to the preparation technology of bone repair materials. Background technique [0002] α-TCP and CaHPO respectively 4 2H 2 O, CaHPO 4 , Ca(H 2 PO 4 ) 2 ·H 2 O, CaCO 3 After mixing with water or solvents, a variety of α-TCP bone cements have been prepared and have been successfully used in clinical practice. Among them, the purity of α-calcium phosphate matrix material is an important factor that directly affects the self-curing time of bone cement, hydration reaction products, and the microstructure and mechanical properties of the material. At present, the preparation method of α-calcium phosphate is prepared by using calcium phosphate salt and calcium carbonate as raw materials, adopting a solid phase reaction method, keeping the temperature at high temperature for a long time, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/32C01B25/32
Inventor 蔡舒姚康德宋雪峰尹玉姬关勇辉
Owner TIANJIN UNIV
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