Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of silk fibroin antibacterial dressing loaded with silver on one side and its preparation method and application

A technology of silk fibroin and solution, applied in the direction of resisting vector-borne diseases, bandages, absorbent pads, etc., can solve the problem of cell toxicity, achieve huge application potential, expand the treatment window, and reduce the effect of cytotoxicity

Active Publication Date: 2022-05-17
SHANDONG UNIV
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no consistent conclusion on the effect of silver-containing dressings on wound healing. The possible reason is that silver is a double-edged sword, which has antibacterial properties and is also toxic to cells.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of silk fibroin antibacterial dressing loaded with silver on one side and its preparation method and application
  • A kind of silk fibroin antibacterial dressing loaded with silver on one side and its preparation method and application
  • A kind of silk fibroin antibacterial dressing loaded with silver on one side and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0062] The second aspect of the present invention provides the preparation method of the silver-loaded silk fibroin antibacterial dressing on one side described in the first aspect, the preparation method comprising the following steps:

[0063] Dissolve sodium carbonate in boiled distilled water, add shredded cocoon shells and stir until degummed, wash and soak the degummed silk fibroin in distilled water to remove residual sodium carbonate on the surface, and dry the cleaned silk fibroin completely at room temperature Dissolve calcium chloride in formic acid to form a formic acid-calcium chloride mixed solution, then add silk fibroin to the above mixed solution and stir until the silk fibroin is completely dissolved to form a silk fibroin solution; add silver nitrate aqueous solution to silk Silver-silk fibroin (Ag-SF) solution is formed in the protein solution, and the silver-silk fibroin solution is evenly dispersed on the mold and volatilized. Antibacterial dressings of s...

Embodiment 1

[0076] Experimental materials and methods:

[0077] (1) Preparation and characterization of SF film and Ag-SF / SF antibacterial dressing

[0078] 1. Preparation of Silk Fibroin Solution

[0079] After heating 1.2L of distilled water to boiling, add 2.55g of sodium carbonate to dissolve, then add 3g of shredded cocoon shells, and continue to cook for 40min until degumming. The degummed silk fibroin was rinsed three times with distilled water, soaked overnight in 1L of distilled water to remove residual sodium carbonate on the surface, and completely dried at room temperature after taking it out. Dissolve and weigh 0.2-1g calcium chloride, dissolve it in 10-15mL formic acid (mass fraction 85-90%), add 1-2g degummed silk fibroin into the above solution and stir until completely dissolved for further use.

[0080] 2. Preparation of SF film and Ag-SF / SF antibacterial dressing

[0081] The Petri dish served as a mold for the preparation of the membrane. First, prepare 0.03-0.24 m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
concentrationaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention specifically relates to a silk fibroin antibacterial dressing loaded with silver on one side, a preparation method and application thereof. Silver has good antibacterial properties and can be added to antibacterial agents on wounds, but studies have shown that silver may also have cytotoxicity and reduce wound cell viability. In view of the above technical problems, the present invention provides a silk fibroin antibacterial dressing with unilateral loading and in-situ generation of AgCl particles. The antibacterial dressing includes a silver-loaded layer and a silk fibroin layer. Provide a good growth environment, at the same time, the silver-loaded layer continuously releases Ag through the buffering effect of the silk fibroin layer + , while reducing cytotoxicity to the wound surface, it also acts as an antibacterial agent. The antibacterial dressing has the advantages of simple preparation process and promotion of wound healing.

Description

technical field [0001] The invention belongs to the technical field of antibacterial wound dressings, and in particular relates to a silver-loaded silk fibroin antibacterial dressing on one side, a preparation method of the antibacterial dressing and an application of the antibacterial dressing as a wound dressing. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Silk fibroin (SF) is a natural protein extracted from silk. It has the ability to promote cell migration, proliferation, angiogenesis and re-epithelialization, and has a similar structure to extracellular matrix, so it is widely used in wound dressings. Dressings using silk fibroin as a scaffold material usually h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/18A61L15/46A61L15/44
CPCA61L15/32A61L15/18A61L15/46A61L15/44A61L2300/104A61L2300/404A61L2300/412C08L89/00Y02A50/30
Inventor 葛少华邵金龙马保金崔雅婷商玲玲
Owner SHANDONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com