Ion exchange system and method for continuously removing impurities in citicoline sodium

Abstract

The invention discloses an ion exchange system and method for continuously removing impurities in citicoline sodium, and mainly solves the problems of low extraction yield and low purity of a discharged product in the prior art. The system comprises a continuous ion exchange resin column unit. The ion exchange resin column unit comprises a plurality of ion exchange resin columns capable of sequentially moving and circularly operating, and the ion exchange resin column unit comprises a separation zone, an elution zone, an alcohol-alkali washing zone, a salt regeneration zone, a salt washing zone, an acid regeneration zone, an acid washing zone, an alkali regeneration zone and an alkali washing zone. The plurality of ion exchange resin columns sequentially move and circularly run in the separation zone, the elution zone, the alcohol-alkali washing zone, the salt regeneration zone, the salt washing zone, the acid regeneration zone, the acid washing zone, the alkali regeneration zone and the alkali washing zone in sequence. Through reasonable configuration, the purity of a discharged product is guaranteed, the purity of citicoline sodium in a separation solution and an eluent reaches 99.8%, and the extraction yield is larger than or equal to 96%.

Description

technical field [0001] The invention belongs to the technical field of biochemical separation, and in particular relates to an ion exchange system and method for continuously removing impurities in citicoline sodium. Background technique [0002] Citicoline Sodium, also known as Citicoline Sodium, is a brain metabolism activator, which is a nucleoside derivative, a prerequisite substance for phosphatidylcholine, and a necessary coenzyme for lecithin synthesis. Studies have shown that citicoline sodium has the functions of repairing brain damage, anti-oxidation, improving memory and enhancing intelligence, and has a wide range of clinical applications. [0003] Currently, the commonly used chemical synthesis method is used to produce citicoline sodium. After the synthesis, the feed liquid adopts a fixed bed ion exchange process, and the manual operation error is large, and the yield is about 85%. The service life of the fixed bed process resin is 30 days, the flow rate of th...

AI Technical Summary

Problems solved by technology

With the time on the column, citicoline sodium will degrade and produce derivative impurities, resulting in a further decrease in yield

[0004] Therefore, there are low extraction yields in the prior art, and the technical problems of low purity of the discharged product need to be solved urgently

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