Unlock instant, AI-driven research and patent intelligence for your innovation.

Modified montmorillonite, preparation method thereof, and application of modified montmorillonite in hemostasis

A montmorillonite and modification technology, applied in the field of modified montmorillonite and its preparation, can solve problems such as red blood cell destruction, achieve the effects of good effect, optimized crystal structure and crystallinity, and excellent in vitro hemostatic ability

Active Publication Date: 2021-12-14
ACADEMY OF MILITARY MEDICAL SCI
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, during the hemostatic process of the existing montmorillonite, it has a certain destructive effect on red blood cells, and its hemostatic performance needs to be further improved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Modified montmorillonite, preparation method thereof, and application of modified montmorillonite in hemostasis
  • Modified montmorillonite, preparation method thereof, and application of modified montmorillonite in hemostasis
  • Modified montmorillonite, preparation method thereof, and application of modified montmorillonite in hemostasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Preparation of modified montmorillonite

[0079] Accurately weigh the pharmaceutical grade montmorillonite, disperse it in deionized water, prepare a 2% (w / v) suspension, put it in a flask, and swell for 6 hours at 60°C and 350r / min stirring conditions to prepare Obtained montmorillonite dispersion. Based on the montmorillonite contained in the montmorillonite dispersion, add 0.01 mol of tranexamic acid per gram of montmorillonite, adjust the pH to about 4 with nitric acid, and stir at 60°C and 350r / min The reaction was continued for 48 hours. After the reaction, the product was centrifuged and washed three times with deionized water. The product was frozen in a -80°C refrigerator, then freeze-dried and ground to obtain a white powder sample, which was the modified montmorillonite.

[0080] In the modified montmorillonite prepared by the above method, the mass ratio of tranexamic acid to montmorillonite is 0.1:1.

Embodiment 2

[0082] Preparation of modified montmorillonite

[0083] Precisely weigh the pharmaceutical grade montmorillonite, disperse it in deionized water, prepare a 1.5% (w / v) suspension, put it in a flask, and swell it for 4 hours at 50°C and 300r / min under stirring conditions to prepare Obtained montmorillonite dispersion. Based on the montmorillonite contained in the montmorillonite dispersion, add 0.008mol of tranexamic acid per gram of montmorillonite, adjust the pH to about 3 with nitric acid, and stir at 70°C and 400r / min The reaction was continued for 50 hours. After the reaction, the product was centrifuged and washed three times with deionized water. The product was frozen in a -80°C refrigerator, then freeze-dried and ground to obtain a white powder sample, which was the modified montmorillonite.

[0084] In the modified montmorillonite prepared by the above method, the mass ratio of tranexamic acid to montmorillonite is 0.075:1.

Embodiment 3

[0086] Preparation of modified montmorillonite

[0087] Precisely weigh the pharmaceutical grade montmorillonite, disperse it in deionized water, prepare a 3% (w / v) suspension, put it in a flask, and swell it at 78°C and 400r / min for 7h to prepare Obtained montmorillonite dispersion. Based on the montmorillonite contained in the montmorillonite dispersion, add 0.02mol of tranexamic acid per gram of montmorillonite, adjust the pH to about 4 with nitric acid, and stir at 55°C and 300r / min The reaction was continued for 55 hours. After the reaction, the product was centrifuged and washed three times with deionized water. The product was frozen in a -80°C refrigerator, then freeze-dried and ground to obtain a white powder sample, which was the modified montmorillonite.

[0088] In the modified montmorillonite prepared by the above method, the mass ratio of tranexamic acid to montmorillonite is 0.12:1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Boiling pointaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a modified montmorillonite, a preparation method thereof, and application of the modified montmorillonite in hemostasis. The modified montmorillonite disclosed by the invention is prepared from raw materials including montmorillonite and tranexamic acid. According to the structural characteristics of montmorillonite and tranexamic acid, the modified montmorillonite is prepared by selecting montmorillonite as an intercalation host material and tranexamic acid as an intercalation guest material by utilizing an intercalation compounding mechanism. The montmorillonite is modified by tranexamic acid, cations such as Na<+> and Ca<2+> in the montmorillonite are replaced, so that the crystal structure and the crystallinity of the montmorillonite are optimized, the properties of the montmorillonite are changed, the montmorillonite shows more excellent in-vitro hemostasis capacity in an in-vitro blood coagulation time experiment, and the hemostatic effect is better than that of the montmorillonite; and the damage of montmorillonite to red blood cells can be reduced, no cytotoxic effect exists, and the use is safer compared with that of montmorillonite.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to a modified montmorillonite, its preparation method and its application in hemostasis. technical background [0002] With the aging of the population in our country and the influence of environmental factors, the incidence of malignant tumors is increasing day by day. Radiotherapy is now one of the effective methods for tumor treatment and plays a vital role in the comprehensive treatment of complex abdominal and pelvic malignant tumors. It plays an important role in improving the local control rate of tumors and improving the quality of life of patients. Radiation enteritis (RE) is mostly intestinal radiation damage caused by abdominal or pelvic malignant tumors receiving radiotherapy. It is a characteristic toxic reaction of radiotherapy and a common complication of radiotherapy. Its incidence rate increases with the wide application of radiotherapy techniques. inc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C01B33/40A61L24/00A61L24/02
CPCC01B33/40A61L24/02A61L24/0015A61L2400/04A61L2300/102A61L2300/418C01P2002/72C01P2002/82C01P2004/03C01P2002/88
Inventor 马飞孟志云孙云波窦桂芳甘慧顾若兰朱晓霞吴卓娜孙文种韩鹏
Owner ACADEMY OF MILITARY MEDICAL SCI
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com