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Tibetan medicine four-ingredient turmeric decoction dropping pill and preparation method thereof

A technology of four-flavor turmeric and decoction pills, applied in the directions of pharmaceutical formulation, pill delivery, drug combination, etc., can solve the problem of uneven appearance of powder and distribution of active ingredients, inconvenient taking of traditional Chinese medicine or Tibetan medicine powder, and fluidity of medicinal powder. It can improve the dissolution rate and bioavailability, improve the clinical treatment effect, and achieve the effect of fast dissolution and dispersion time limit.

Pending Publication Date: 2021-12-21
西藏神猴药业有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason is that there are many shortcomings in traditional Chinese medicine or Tibetan medicine powder, such as: the appearance of the powder and the uneven distribution of active ingredients due to the differences in the water content, oil content, density and particle size of different Chinese medicinal powders; The fluidity of medicinal powder is not good, resulting in large differences in the filling volume of powder; Chinese medicinal materials themselves carry a large amount of microorganisms and a lot of water, and it is difficult to fully sterilize them, which leads to the limit of microorganisms easily exceeding the standard; traditional Chinese medicine or Tibetan medicine powder It is inconvenient to take, especially the "boiled powder" takes a lot of time to decoct, and the obtained decoction tastes bitter and irritating, which is difficult for patients to accept

Method used

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  • Tibetan medicine four-ingredient turmeric decoction dropping pill and preparation method thereof
  • Tibetan medicine four-ingredient turmeric decoction dropping pill and preparation method thereof
  • Tibetan medicine four-ingredient turmeric decoction dropping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Step (1): Weigh 150g of turmeric, 125g of barberry bark, 250g of emblica and 250g of Tribulus according to the weight ratio of the prescription of Tibetan medicine Siwei turmeric decoction, grind them into coarse powder, and extract twice with 75% ethanol under reflux, each time for 2 hours, The dosage of 75% ethanol is 11.6kg each time, the extracts are combined, allowed to cool, suction filtered, and the ethanol is recovered under reduced pressure until there is no alcohol smell to obtain a concentrated solution.

[0023] Step (2): Use D101 macroporous adsorption resin to purify the concentrated solution obtained in step (1). The amount of D101 macroporous adsorption resin (wet state) is 2.7kg, and the specification of the chromatographic column is 7× 100cm, the ratio of diameter to height of the resin is 1:9, load the non-alcohol-flavored concentrated medicinal solution prepared by step (1) at a speed of 20ml / min, let it stand for 12 hours after loading, and use 8L of...

Embodiment 2

[0026] Step (1): Weigh 150g of turmeric, 125g of barberry bark, 250g of emblica and 250g of Tribulus according to the weight ratio of the prescription of Tibetan medicine Siwei turmeric soup, grind them into coarse powder, and reflux extract with 75% ethanol for 3 times, 1 hour each time, The dosage of 75% ethanol is 11.6kg each time, the extracts are combined, let cool, suction filtered, and the ethanol is recovered under reduced pressure until there is no alcohol smell;

[0027] Step (2): Purify the concentrate obtained in step (1) with D101 macroporous adsorption resin, the amount of D101 macroporous adsorption resin (wet state) is 2.7kg, and the size of the chromatographic column is 8×100cm , the diameter-to-height ratio of the resin is 1:6. Load the non-alcohol-flavored concentrated medicinal solution prepared in step (1) at a rate of 20ml / min. Wash away the impurities at a high speed, and then use 10L of 80% ethanol to elute at a speed of 40ml / min, collect the eluate, re...

Embodiment 3

[0030]Step (1): Weigh 150g of turmeric, 125g of barberry bark, 250g of emblica and 250g of Tribulus according to the weight ratio of the prescription of Tibetan medicine Siwei turmeric decoction, grind them into coarse powder, and extract twice with 75% ethanol under reflux, each time for 2 hours, The dosage of 75% ethanol is 11.6kg each time, the extracts are combined, allowed to cool, suction filtered, and the ethanol is recovered under reduced pressure until there is no alcohol smell to obtain a concentrated solution.

[0031] Step (2): Use D101 macroporous adsorption resin to purify the concentrated solution obtained in step (1). The amount of D101 macroporous adsorption resin (wet state) is 2.7kg, and the specification of the chromatographic column is 7× 100cm, the ratio of diameter to height of the resin is 1:9, load the non-alcohol-flavored concentrated medicinal solution prepared by step (1) at a speed of 20ml / min, let it stand for 12 hours after loading, and use 8L of ...

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Abstract

The invention discloses a Tibetan medicine four-ingredient turmeric decoction dropping pill and a preparation method thereof. The Tibetan medicine four-ingredient turmeric decoction dropping pill is prepared from a Tibetan medicine four-ingredient turmeric decoction extracted purified product, polyethylene glycol and a surfactant, the weight ratio of the Tibetan medicine four-ingredient turmeric decoction extracted purified product to the polyethylene glycol to the surfactant is 1: (4-8): (0.05-0.2), and the surfactant is selected from soybean lecithin and poloxamer 188. The preparation method mainly comprises the following steps that alcohol extraction is carried out on the medicinal materials according to the prescription of the Tibetan medicine four-ingredient turmeric decoction powder, the extracted concentrated solution is purified by using D101 macroporous adsorption resin, and the purified fine powder is dispersed into a matrix to prepare the dropping pill. The Tibetan medicine four-ingredient turmeric decoction dropping pill is short in dissolution time limit, convenient to take and long in shelf life, and covers the unpleasant odor and irritation of the original powder.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a Tibetan medicine Siwei Jianghuang Decoction dripping pill and a preparation method thereof. Background technique [0002] Tibetan medicine Siwei Jianghuang Decoction is included in the "Drug Standards of the Ministry of Health-Tibetan Medicine Volume One". It is composed of 15g of turmeric, 12.5g of barberry bark, 25g of emblica and 25g of Tribulus terrestris. It has the effects of clearing away heat and diuresis. At present, the powder of Tibetan medicine Siwei Jianghuang Decoction is mostly used in the treatment of urethritis, frequent urination, and urgency. Its preparation method is to take four kinds of medicinal materials according to the proportion of the prescription, grind them into coarse powder, sieve, and mix well to obtain. The usage is to take 4-5g at a time, decoct in water, twice a day. [0003] Turmeric, pungent, bitter, warm in nature, can cure poi...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/20A61K47/10A61K47/24A61P13/02
CPCA61K36/9066A61K36/29A61K36/47A61K36/185A61K9/2031A61K9/2013A61P13/02A61K2236/333A61K2236/55A61K2300/00
Inventor 谢和兵尼玛次仁白玛旦增
Owner 西藏神猴药业有限责任公司
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