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Application of 12-HEPE or pharmaceutically acceptable fatty acid thereof in alleviation of spermatogenesis disorder

A 12-HEPE and 1.12-HEPE technology, applied in the field of biomedicine, can solve the problems of poorly understood cellular and molecular mechanisms of spermatogonial regeneration

Active Publication Date: 2021-12-31
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many factors that promote spermatogenesis in mice, the cellular and molecular mechanisms underlying spermatogonial regeneration remain poorly understood

Method used

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  • Application of 12-HEPE or pharmaceutically acceptable fatty acid thereof in alleviation of spermatogenesis disorder
  • Application of 12-HEPE or pharmaceutically acceptable fatty acid thereof in alleviation of spermatogenesis disorder
  • Application of 12-HEPE or pharmaceutically acceptable fatty acid thereof in alleviation of spermatogenesis disorder

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Experimental program
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Embodiment 1

[0046] This example is based on the results of targeted metabolomics detection of eicosanoids in testicular tissue in the NOA model group induced by busulfan and the Omega-3 administration group. Significantly increased in the figure 1As shown, the recovery potential of 12-HEPE administration to NOA mice on spermatogenesis disorder was further verified.

[0047] The specific verification steps are as follows:

[0048] 1. Selection of experimental materials:

[0049] B6 ordinary mice, male, weighing 20-25 g, 5 weeks old, SPF grade were used as animals; Omega-3 was selected from Chengdu Guowei Biomedical Co., Ltd.; 12-HEPE was selected from GlpBio Company of the United States.

[0050] 2. Raising conditions for mice:

[0051] All mice were free to forage for food and drink water, and were reared at a room temperature of 25±2°C and a relative humidity of 40%-70%; light and dark alternated for 12 hours, and the experiment began after the mice were adaptively fed for one week. ...

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Abstract

The invention discloses novel application of 12-HEPE or pharmaceutically acceptable fatty acid thereof, and comprises the application of the 12-HEPE or the pharmaceutically acceptable fatty acid thereof in preparation of a medicine for treating NOA. The 12-HEPE or the pharmaceutically acceptable fatty acid thereof can play a therapeutic role by promoting proliferation and differentiation of the endogenous spermatogonium of a mouse damaged by busulfan, and experiments prove that recovery of the thickness and the integrity of the spermatogenic epithelium of the testis and the recovery of the sperm concentration of the tail of epididymiscan be observed through intragastric administration of the 12-HEPE into the NOA mouse induced by the busulfan, meanwhile, proliferation and differentiation of spermatogonium are promoted, expression of the paracrine factors of cells is supported, so that the 12-HEPE can be used as a new target for alleviating the spermatogenesis dysfunction of the testis of the NOA mouse, and a new method is provided for treating the non-obstructive azoospermia.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of 12-HEPE or its pharmaceutically acceptable fatty acid in improving spermatogenesis disorder. Background technique [0002] Male infertility has become an important issue in human health. Globally, more than 10% of couples are infertile, and male factor accounts for half of infertility. The most common cause of male infertility is primary testicular dysfunction, usually characterized by abnormal spermatogenesis, clinically manifested as non-obstructive azoospermia (NOA). [0003] Spermatogenesis is the precise process by which spermatogonia produce sperm cells through the stages of mitosis, meiosis, spermatogenesis, and sperm release. Spermatogenesis is regulated by a unique testicular microenvironment composed of Sertoli cells, stromal cells, peritubular myoid cells and their secretory bodies, including bone morphogenetic proteins (BMPs), glial-derived n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/202A61P15/08
CPCA61K31/202A61P15/08
Inventor 靖俊姚兵欧阳磊李朝军张红孙珊珊赵山美子唐婷赵薇戈一峰
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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