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Natural skin care compositions and methods for treating oxidative stress and restoring skin health

An oxidative stress, composition technology, used in skin care preparations, drug combinations, skin diseases, etc.

Pending Publication Date: 2022-01-07
コーデックスビューティーコーポレーション
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as noted above, given the sheer number of combinatorial permutations that exist, based on the number of ingredients that can be chosen, the successful formulation of such products is based more on luck and chance, as opposed to routine experimentation

Method used

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  • Natural skin care compositions and methods for treating oxidative stress and restoring skin health
  • Natural skin care compositions and methods for treating oxidative stress and restoring skin health
  • Natural skin care compositions and methods for treating oxidative stress and restoring skin health

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0110] A mixture of bilberry + Buddleia japonica + Bilberry leaf extracts was evaluated via an enzymatic assay in lysate cells (hereinafter, " M3") for total glutathione quantification and superoxide dismutase (SOD) activity. Multiscan GO units available from Thermo Fisher Scientific of Waltham, MA (Thermo Fisher Scientific of Waltham, MA) were used. Absorbance readings were taken at 410nm for total glutathione and 450nm for SOD on a chromatograph. Quantitative values ​​were normalized by total protein in the sample using the Bradford technique as described in Analytical Biochemistry (Anal. Biochem), 72:248-254.

[0111] Seed primary human fibroblasts in 75cm 2 flask, culture, and incubator at 37 °C in 5% CO 2 Amplified in the presence. After reaching confluency, cells were seeded in well plates and exposed to hydrogen peroxide and quantified mediator.

[0112] For statistical evaluation, an analysis of variance (ANOVA) test was used to initially measure the variance of t...

example 2

[0119] In this instance, the evaluation Photoprotection of M3 against visible light in the range 400-700nm, as long-term exposure to visible light has been shown to induce oxidative stress, which may contribute to unwanted skin pigmentation (dark spots), inflammation and oxidative photoaging. Visible blue radiation (440-485nm), also known as "blue light," is able to penetrate deeper into the skin than UVA and UVB light, all the way to the dermis where collagen and elastin are located. In addition to the sun, electronic devices such as smartphones and computer screens emit blue light, which most people are exposed to in large amounts on a daily basis. The potential negative photoaging consequences of such exposures on the skin are troubling.

[0120] In order to evaluate its blocking ability, the Films of M3 were applied to Helioplate HD6 substrates from HelioScreen Labs. Transmission spectra were then obtained using a UV 2450 Shimadzu spectrophotometer (ISR-240A) with an ...

example 3

[0123] The leaf extracts bilberry and berry were evaluated for their ability to prevent the formation of undesired thymidine dimers when exposed to UVB radiation. When the skin is exposed to UVB radiation, the thymidine bases in DNA can absorb the UVB radiation to form thymidine dimers (also known as thymine dimers) in the DNA, complicating the cells' efforts to replicate DNA and function properly change. In this experiment, an in vitro thymidine dimer assay was performed using a skin model consisting of normal human-derived epidermal keratinocytes cultured to form a multilayer model of human epidermis.

[0124] One group of tissues was treated with Chilean berry leaf extract for seven days, another group of tissues was tested with bilberry leaf extract for seven days, and a third group was not treated. All three tissue groups were then exposed to 300mJ / cm 2 of UVB radiation. DNA was then extracted and analyzed for thymidine dimer content.

[0125] The DNA is then immobili...

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Abstract

The present disclosure is directed to a composition intended for application onto human skin suffering from oxidative stress, the composition comprising: (1) a mixture of at least: (a) a leaf extract of Aristotelia chilensis; (b) a leaf extract of Buddleja globosa; (c) a leaf extract of Ugni molinae; (d) optionally, a bark / seed extract of Entada phaseoloides; (e) optionally, a blend of Pfaffia paniculata, Ptychopetalum olacoides, and Lilium candidum extracts; and (f) at least one humectant; (2) an emulsifier; and (3) a dermatologically acceptable carrier, wherein (a) to (f) are employed in amounts sufficient to synergistically neutralize existing free radicals present in the skin, while proactively priming the skin in order to enhance its ability to protect itself against free radical aggression, thereby helping to enhance its health and appearance, and wherein the composition is natural and free of a skin sensitizing-effective amount of an essential oil.

Description

technical field [0001] The present disclosure generally relates to compositions and methods for treating skin suffering from oxidative stress. More specifically, the present disclosure relates to the use of specific combinations of botanical extracts and preservative systems to achieve compositions and methods that enhance the antioxidant defense potential, hydration and barrier function of skin suffering from oxidative stress. Background technique [0002] The skin is damaged by many extrinsic (environmental) and intrinsic factors. Examples of extrinsic factors include exposure to ultraviolet (UV) rays emitted by the sun, and harmful chemical agents found in atmospheric pollution such as smog and cigarette smoke. Intrinsic factors that negatively affect the skin include, for example, chronological aging, an individual's genetic makeup, and other biological changes that occur within the skin. These factors cause the skin to experience detrimental cellular effects associate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/34A61K8/99A61K8/36A61K8/368A61Q19/08A61Q19/00A61Q17/04
CPCA61K8/9794A61K8/9789A61K8/345A61K8/99A61K8/36A61K8/368A61Q19/08A61Q19/00A61Q17/04A61K2800/524A61K2800/5922A61K2800/85A61K2800/522A61K8/9783A61K8/365A61K2800/59A61P17/18
Inventor M·康奈尔B·A·帕尔杜斯J·I·萨纽埃萨塞普尔维达
Owner コーデックスビューティーコーポレーション
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