A kind of continuous array gradient nanofiber bionic scaffold and preparation method thereof

Abstract

The invention relates to a continuous array gradient nanofiber bionic support and a preparation method thereof. The method comprises the steps of first performing electrospinning to obtain an array gradient nanofiber membrane, and then performing sterilization and cross-linking treatment to obtain the continuous array gradient nanofiber biomimetic. bracket. Among them, the receiving device for electrospinning includes a printed circuit board and a ring electrode; the printed circuit board includes an insulating substrate and a plurality of pads, and the pads are distributed in the following way: one pad is distributed in the center of the insulating substrate, and the rest The pads form several annular array pad groups distributed in a circle; the bottom of the annular electrode is fixed on the insulating substrate, and from the top perspective of the annular electrode, the circle formed by the inner wall of the annular electrode is connected with each annular array pad group. The circles formed are concentric circles. The center of the concentric circles is the exact center of the insulating substrate. The stent of the present invention has a continuous array gradient fiber structure, which can release the drug in different concentrations at the edge and center of the wound surface.

Description

technical field [0001] The invention belongs to the technical field of bionic stents, and relates to a continuous array gradient nanofiber bionic stent and a preparation method thereof. Background technique [0002] The high specific surface area of ​​electrospun nanofibers can improve the interaction of dressings with the wound microenvironment, while their extracellular matrix-mimicking properties make them promising for wound care, drug delivery, and biotechnological applications. Nanofibrous mats have been shown to be ideal for modern effective wound therapy and wound care, and they are efficiently and inexpensively produced in an electrospinning process, offering a variety of promising strategies for modern wound therapy. [0003] Studies have shown that by incorporating drugs, growth factors, etc. into the dressing, wounds can be repaired faster and better, and the gradient distribution of bioactive substances plays a crucial role in the healing of skin wounds, and the...

AI Technical Summary

Problems solved by technology

[0004] Patent CN107510862B uses electrospinning junction electrode-ring electrode composite receiving device to prepare an ordered fiber scaffold carrying gradient concentration bioactive molecules, but there are few overlapping fibers and less chemokine loading; The interaction between them is weak, the mechanical properties of the scaffold are poor, and the performance of promoting wound healing is not good.

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