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Precise block polymer nanoassembly and preparation method thereof

A technology of block polymer and nano-assembly, which is applied in the field of precise block polymer nano-assembly and its preparation, can solve the problems of lack of mature technical rules and difficult realization, and achieves good uniformity and repeatability. The effect of single molecular weight and low dispersion

Active Publication Date: 2022-01-14
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, it is not easy to obtain block polymer nanoassemblies and achieve good preparation effects (such as good repeatability, uniform size, etc.), which are closely related to the type and preparation method of block polymers, but there is no Mature technical rules, therefore, how to better prepare nano-assemblies has become a widely concerned issue in the industry

Method used

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  • Precise block polymer nanoassembly and preparation method thereof
  • Precise block polymer nanoassembly and preparation method thereof
  • Precise block polymer nanoassembly and preparation method thereof

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preparation example Construction

[0096] The present invention also provides a method for preparing the block polymer nano-assembly described in the above technical scheme, comprising the following steps:

[0097] a) dissolving the block polymer of formula I in an organic solvent to obtain a solution;

[0098] b) After mixing the dissolving solution with water, the organic solvent is removed by dialysis to form a nano-assembly.

[0099] In the present invention, for the preparation of nanospheres, there are specifically two preparation methods, and the first preparation method includes the following steps:

[0100] a1) dissolving the block polymer of formula I in an organic solvent to obtain a solution;

[0101] b1) After adding the dissolving solution into rapidly stirring water, the organic solvent is removed by dialysis to form nanospheres.

[0102] Regarding step a1):

[0103] The block polymer of formula I is preferably: n is an integer selected from 1 to 6, R=R 1 =H. The organic solvent is one or mo...

Embodiment 1

[0141] Example 1 Preparation of block polymer T-A of formula I 4 -dPEG spherical nanoparticles

[0142] 1.1 Preparation

[0143] The block polymer T-A 4 -dPEG was dissolved in dioxane (1 mg / mL) to obtain a solution. Under the stirring condition of 1000 rpm, 1 mL of the above dissolving solution was quickly poured into 9 mL of water at one time, and the stirring was continued for 2 h. Then, the solution was transferred to a dialysis membrane and dialyzed against water to remove the organic solvent, and dialyzed against pure water and changed the water several times to obtain an aqueous solution of the nano-assembly.

[0144] 1.2 Characterization and testing

[0145] Cryo-electron microscope test chart is as follows figure 1 shown, figure 1 For the T-A gained in Example 1 4 - Cryo-TEM image of spherical nanoparticles of dPEG. It can be seen that the obtained assemblies are spherical nanoparticles with an average diameter of about 20 nm.

[0146] Performance testing of t...

Embodiment 2

[0150] Example 2 Preparation of block polymer T-A of formula I 6 -dPEG spherical nanoparticles

[0151] 1.1 Preparation

[0152] The block polymer T-A 6 -dPEG was dissolved in 1,4-dioxane (1 mg / mL) to obtain a solution. Under the stirring condition of 500 rpm, 9 mL of water was added to the above-mentioned dissolving solution containing 1 mL of solvent by using a syringe pump at a water addition rate of 1 mL / h, and the stirring was continued for 2 h. Then, the solution was transferred to a dialysis membrane and dialyzed against water to remove the organic solvent, and dialyzed against pure water and changed the water several times to obtain an aqueous solution of the nano-assembly.

[0153] 1.2 Characterization and testing

[0154] Cryo-electron microscope test chart is as follows figure 2 shown, figure 2 For the T-A gained in Example 2 6 - Cryo-TEM image of spherical nanoparticles of dPEG. It can be seen that the obtained assemblies are spherical nanoparticles with ...

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Abstract

The invention provides a precise block polymer nanoassembly and a preparation method thereof. According to the invention, a precise amphiphilic block polymer with a structure as shown in a formula I is adopted as a matrix; and a controllable nanoassembly, namely a spherical micelle and / or rod-like micelle structure can be formed by adjusting the length and sequence structure of a hydrophobic chain segment and utilizing of cooperation with other operations and condition control; and the obtained nanoassembly is low in dispersity, good in stability, good in uniformity and repeatability and single in molecular weight, so the biological distribution of the nanoparticles corresponding to the polymer in a living body can be conveniently quantified by using a mass spectrum. The preparation method provided by the invention is simple and easy to implement, and product repeatability is good.

Description

technical field [0001] The invention relates to the field of nano biomaterials, in particular to a precise block polymer nano assembly and a preparation method thereof. Background technique [0002] Since the advent of nanotechnology, a lot of work has been devoted to the preparation and application of nanomaterials. One of the important application aspects is nano-biomaterials, through different methods to construct nano-materials with specific physical properties (such as rigidity, size and shape, etc.) to study their metabolism and distribution in vivo, or to give them specific functional applications for the diagnosis or treatment of disease. [0003] The construction methods of nanomaterials mainly include "top-down" and "bottom-up" methods. The difference between the two approaches is the process of creating nanoscale structures. In the bottom-up approach, nanoscale materials are built from atomic or molecular precursors that can react and grow in size, or self-assem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C271/28C07C269/00A61K9/107A61K47/34A61K47/18
CPCC07C271/28C07C269/00A61K9/1075A61K47/34A61K47/183
Inventor 刘世勇石强强
Owner UNIV OF SCI & TECH OF CHINA
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