7 results about "Bio distribution" patented technology

This invention relates to a self-adjuvanted biomimetic lipid nanoparticle, its microfluidic assembly method, and its anti-tumor applications. The self-adjuvanted biomimetic lipid nanoparticle has a structure in which an activated dendritic cell membrane (ADCM) is coated on the surface of a lipid nanoparticle (LNP) loaded with mRNA. The advancements of this invention compared to traditional LNPs are: the self-adjuvanted biomimetic lipid nanoparticle (ADCM-LNP) exhibits a faster cellular uptake rate and higher transfection efficiency, thereby inducing a strong Th1-type immune response and a potent CTL-mediated tumor-killing effect. In vivo biodistribution studies have shown that this system exhibits significant spleen-targeting (splenic tropism) and demonstrates excellent therapeutic efficacy in a HER2-positive breast cancer model.

The present disclosure discloses a brand-new skeleton 99mTc-FAPI diagnostic probe and use thereof in the preparation of a drug or a reagent for diagnosing tumors, wherein the structural formula of a dimeric compound targeting FAP is shown by following formula. Compared with conventional FAP inhibitor radiopharmaceuticals, technetium-99m-labeled novel skeleton FAP inhibitor dimeric compound has a very high tumor uptake rate, high contrast between tumor and background and good in vivo biodistribution.

This invention discloses a 99mTc-FAPI diagnostic probe having a novel skeleton and its application in the manufacture of a tumor diagnostic drug or reagent, the structural formula of the FAP-targeting dimer compound is shown in the following formula. Compared to conventional FAP inhibitor radiopharmaceuticals, the technetium-99m-labeled FAP inhibitor dimer compound having a novel skeleton exhibits a very high tumor uptake rate, high contrast between tumor and background, and good in vivo biological distribution. [C28] TIFF2026518096000031.tif51170

The present disclosure provides a modified AAV capsid protein comprising a targeting peptide in variable region VIII (VR VIII) and / or a peptide segment in variable region I (VR 1). The modified AAV capsid protein can form a rAAV that has a preferred tropism, specificity, or biodistribution in vivo or in vitro. The rAAV of the present disclosure can be used for gene therapy targeted at a particular tissue.

This invention discloses a microbial detection and analysis instrument, belonging to the technical field of microbial detection equipment. It includes a central control unit, a filter connector, a filter cup, a sample inlet tube, a rotating assembly, a lifting assembly, an elastic support frame, a dual turbidity sensing unit, and a flow rate sensor. The filter cup has a split structure, and the elastic support frame provides flexible support for the filter membrane. The rotating and lifting assemblies drive the sample inlet tube and stirring blades to rotate and move, completing sample stirring, anti-clogging, and cleaning. The dual turbidity sensing unit collaboratively detects microbial retention, and the flow rate sensor monitors the degree of clogging, forming a dual closed loop of detection and control. This invention solves the problems of uneven microbial distribution, easily damaged filter membranes, low detection efficiency, and insufficient automation in existing instruments. It is suitable for industrial scenarios such as clinical sample testing and batch sample screening, improving detection accuracy and intelligence, and has good industrial application value.

The present disclosure provides a modified AAV capsid protein comprising a targeting peptide in variable region VIII (VR VIII). The modified AAV capsid protein can form an rAAV, which has a preferred tropism, specificity or biodistribution in vivo or in vitro. The rAAV of the present disclosure can be used for gene therapies targeted at a specific tissue.

This utility model relates to the field of bio-fermentation technology and discloses a bio-fermentation system, including a fermenter. A top plate is bolted to the top surface of the fermenter, and a ring is fixedly connected to the top surface of the top plate. A top cover is bolted to the top surface of the ring, and a connecting plate is fixedly connected to the inner wall of the ring. A worm gear is rotatably connected to the outer surface of the connecting plate, and a worm wheel is driven by the worm gear. A hollow rotating rod is fixedly connected inside the worm wheel, and a rotary joint is rotatably connected to the top of the hollow rotating rod. A stirring head is fixedly connected to the bottom of the hollow rotating rod. This utility model uses a geared motor to drive a series of transmission structures, causing the stirring head and stirring blades to stir the lower and middle layers of material, while the stirring head and another set of stirring blades stir the upper layers of material. The stirring range covers the entire interior of the fermenter, effectively avoiding differences in substrate concentration, microbial distribution, and nutrient composition in different areas of the fermenter, ensuring the consistency and stability of the fermentation reaction.