14 results about "Bio distribution" patented technology

The application discloses a kind of aquatic habitat positioning prediction methods, it is related to aquatic habitat distribution research field.The present application establishes the aquatic habitat positioning framework of suitable area + suitable river reach by integrating the target biological distribution point and the environmental condition of river reach in target area.The fine prediction of aquatic habitat is realized in the multi-scale of area plus river reach, when facing the need of target biological habitat prediction in wide range area, fine positioning can be realized, so as to help fine management of aquatic organism, which has important guiding significance and practical significance for maintaining ecosystem stability.The common characteristics of suitable river reach are obtained by comparing after predicting suitable river reach, so as to identify and judge the potential habitat of target organism, the identification of potential habitat can expand the positioning range of target biological habitat, which can effectively avoid habitat omission and protection in time.

This invention relates to a self-adjuvanted biomimetic lipid nanoparticle, its microfluidic assembly method, and its anti-tumor applications. The self-adjuvanted biomimetic lipid nanoparticle has a structure in which an activated dendritic cell membrane (ADCM) is coated on the surface of a lipid nanoparticle (LNP) loaded with mRNA. The advancements of this invention compared to traditional LNPs are: the self-adjuvanted biomimetic lipid nanoparticle (ADCM-LNP) exhibits a faster cellular uptake rate and higher transfection efficiency, thereby inducing a strong Th1-type immune response and a potent CTL-mediated tumor-killing effect. In vivo biodistribution studies have shown that this system exhibits significant spleen-targeting (splenic tropism) and demonstrates excellent therapeutic efficacy in a HER2-positive breast cancer model.

The present disclosure discloses a brand-new skeleton 99mTc-FAPI diagnostic probe and use thereof in the preparation of a drug or a reagent for diagnosing tumors, wherein the structural formula of a dimeric compound targeting FAP is shown by following formula. Compared with conventional FAP inhibitor radiopharmaceuticals, technetium-99m-labeled novel skeleton FAP inhibitor dimeric compound has a very high tumor uptake rate, high contrast between tumor and background and good in vivo biodistribution.

The application discloses a microorganism spatial distribution monitoring method and system based on multi-level microscopic scanning images, relates to the field of image processing, and adopts multi-level grid traversal scanning image collection on the observation area of microscopic data, identifies and counts the number of each target microorganism in each image and the position information of each target microorganism in the corresponding level grid, and stores each target microorganism in the corresponding to-be-identified level data set; according to the ecological type of each target microorganism, the corresponding to-be-identified level data set is respectively input into the corresponding trained multi-organism distribution probability density model, and the spatial distribution law of each type of microorganism in the microscopic data is obtained. The multi-level magnification grading scanning is adopted, the interspecific interaction and distribution law of microorganisms are respectively described according to the ecological type of microorganisms, and the observation accuracy of the distribution of microorganisms is improved.

The present disclosure provides a modified AAV capsid protein comprising a targeting peptide in variable region VIII (VR, VIII) and / or a peptide segment in variable region I (VR I). The modified AAV capsid protein can form an rAAV, which has a preferred tropism, specificity or biodistribution in vivo or in vitro. The rAAV of the present disclosure can be used for gene therapies targeted at a specific tissue.

The present disclosure provides a modified AAV capsid protein comprising a targeting peptide in a variable region VIII (VRVIII). The modified AAV capsid protein may form an rAAV having a preferred tropism, specificity, or biological distribution in vivo or in vitro. The rAAVs of the present disclosure can be used in gene therapy targeting specific tissues.

The invention discloses a ship ultraviolet light organism adhesion prevention device and method fused with visual analysis, and relates to the technical field of ship antifouling, and the method comprises the steps: obtaining the type of an organism adhered to a ship body; a target frequency corresponding to the biological type is obtained, the action range of the ultraviolet lamp set at the installation position is obtained through analysis, and the part, below the water surface, of the ship body is divided into at least one local area; analyzing to obtain the real-time seawater temperature of the local area, analyzing to obtain the real-time seawater flow velocity and the biological distribution condition of the local area, and setting the operation frequency of the ultraviolet lamp group corresponding to the local area; and establishing an ultraviolet lamp intensity loss model, and setting the operation intensity of the ultraviolet lamp group corresponding to the local area. The biological distribution condition, the real-time seawater temperature and the real-time seawater flow velocity are obtained in an image analysis mode, and the established ultraviolet lamp intensity loss model is combined, so that the illumination setting is consistent with the actual condition as much as possible, the energy efficiency is improved, and the illumination mode is optimized.

This invention discloses a 99mTc-FAPI diagnostic probe having a novel skeleton and its application in the manufacture of a tumor diagnostic drug or reagent, the structural formula of the FAP-targeting dimer compound is shown in the following formula. Compared to conventional FAP inhibitor radiopharmaceuticals, the technetium-99m-labeled FAP inhibitor dimer compound having a novel skeleton exhibits a very high tumor uptake rate, high contrast between tumor and background, and good in vivo biological distribution. [C28] TIFF2026518096000031.tif51170

The present disclosure provides a modified AAV capsid protein comprising a targeting peptide in variable region VIII (VR VIII) and / or a peptide segment in variable region I (VR 1). The modified AAV capsid protein can form a rAAV that has a preferred tropism, specificity, or biodistribution in vivo or in vitro. The rAAV of the present disclosure can be used for gene therapy targeted at a particular tissue.

This invention discloses a microbial detection and analysis instrument, belonging to the technical field of microbial detection equipment. It includes a central control unit, a filter connector, a filter cup, a sample inlet tube, a rotating assembly, a lifting assembly, an elastic support frame, a dual turbidity sensing unit, and a flow rate sensor. The filter cup has a split structure, and the elastic support frame provides flexible support for the filter membrane. The rotating and lifting assemblies drive the sample inlet tube and stirring blades to rotate and move, completing sample stirring, anti-clogging, and cleaning. The dual turbidity sensing unit collaboratively detects microbial retention, and the flow rate sensor monitors the degree of clogging, forming a dual closed loop of detection and control. This invention solves the problems of uneven microbial distribution, easily damaged filter membranes, low detection efficiency, and insufficient automation in existing instruments. It is suitable for industrial scenarios such as clinical sample testing and batch sample screening, improving detection accuracy and intelligence, and has good industrial application value.

The present disclosure provides a modified AAV capsid protein comprising a targeting peptide in variable region VIII (VR VIII). The modified AAV capsid protein can form an rAAV, which has a preferred tropism, specificity or biodistribution in vivo or in vitro. The rAAV of the present disclosure can be used for gene therapies targeted at a specific tissue.

This utility model relates to the field of bio-fermentation technology and discloses a bio-fermentation system, including a fermenter. A top plate is bolted to the top surface of the fermenter, and a ring is fixedly connected to the top surface of the top plate. A top cover is bolted to the top surface of the ring, and a connecting plate is fixedly connected to the inner wall of the ring. A worm gear is rotatably connected to the outer surface of the connecting plate, and a worm wheel is driven by the worm gear. A hollow rotating rod is fixedly connected inside the worm wheel, and a rotary joint is rotatably connected to the top of the hollow rotating rod. A stirring head is fixedly connected to the bottom of the hollow rotating rod. This utility model uses a geared motor to drive a series of transmission structures, causing the stirring head and stirring blades to stir the lower and middle layers of material, while the stirring head and another set of stirring blades stir the upper layers of material. The stirring range covers the entire interior of the fermenter, effectively avoiding differences in substrate concentration, microbial distribution, and nutrient composition in different areas of the fermenter, ensuring the consistency and stability of the fermentation reaction.

The invention relates to a rare earth up-conversion nano-particle carrier and a preparation method and application thereof, belongs to the technical field of nano-drug carriers, and aims to solve the problems that the dynamic distribution law and biological distribution characteristics of the conventional nano-carrier cannot be fully investigated, and the stability of the nano-carrier is poor. The existing carrier has at least one of the problems of poor stability, poor water solubility, low drug loading capacity and the like. The rare earth up-conversion nano-particle carrier is of a multi-layer core-shell structure, macromolecular chains on the surface of the rare earth up-conversion nano-particle carrier obtained through the method can fully stretch, on one hand, a better steric hindrance effect is provided, and the water dispersibility and stability of the rare earth up-conversion nano-particle carrier are improved; on the other hand, mutual overlapping and sinking between surface adsorption macromolecular chains are reduced, so that more anchoring points are provided, and efficient loading of vaccines / drugs is achieved.