SNP marker site related to adaptability of horse plateau hypoxia and application of SNP marker site

A technique for marking sites and plateau hypoxia, which is applied in the field of genetic engineering to achieve the effect of reducing the concentration

Active Publication Date: 2022-01-18
FOSHAN UNIVERSITY +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the SNP loci related to Tf gene and high-altitude adaptability of horses have not been reported yet.

Method used

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  • SNP marker site related to adaptability of horse plateau hypoxia and application of SNP marker site
  • SNP marker site related to adaptability of horse plateau hypoxia and application of SNP marker site
  • SNP marker site related to adaptability of horse plateau hypoxia and application of SNP marker site

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Experimental program
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Effect test

Embodiment

[0022] 1. Collection of experimental animals and blood samples

[0023] The present invention is used for whole genome resequencing samples, respectively from Qusong County, Tibet Autonomous Region (4500m, 20 horses), Diqing Prefecture, Yunnan Province (3500m, 10 horses), Zuogong County, Tibet Autonomous Region (3500m, 10 horses), Yunnan Province Laojun Mountain (2500m, 10 horses), Lijiang City, Yunnan Province (2500m, 10 horses), Yimen County, Yunnan Province (1500m, 10 horses), Zhaotong City, Yunnan Province (1500m, 10 horses), Pingbian County, Yunnan Province (500m , 10 horses), Yingjiang County, Yunnan Province (500m, 10 horses).

[0024] A total of 174 Diqing Tibetan horse samples were used for the analysis of the association between genotype and blood physiology, and the samples came from Diqing Prefecture, Yunnan.

[0025] 5ml of blood was collected from the jugular vein of horses using vacuum blood collection tubes containing EDTA anticoagulant, for a total of 274 sam...

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Abstract

The invention relates to an SNP marker site related to the adaptability of horse plateau hypoxia and application thereof, and belongs to the fields of gene engineering and genetic engineering. The SNP marker is located at the 58bp of the 13th exon of a Transferrin gene of a No.16 chromosome of a horse (GAT-> AAT). The Tf gene is a hypoxia selection site of a horse, the transferrin is a carrier protein for synthesizing iron from hemoglobin, the structural function of the transferrin is related to the hemoglobin content, and the Tf gene mutant (AA) can reduce the iron carrying capacity of the horse, so that the hemoglobin concentration, the erythrocyte count and the hematocrit are reduced. The site on the Tf gene related to horse plateau hypoxia tolerance can be used as a molecular marker for horse hypoxia tolerance and plateau adaptability, and also has important significance for preservation and utilization of Tibetan horse characteristic genes.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and specifically relates to a SNP marker site related to horse plateau hypoxia adaptability and application thereof. Background technique [0002] In ancient times, horses were once the main labor force in activities such as agricultural production, transportation and military warfare. With the development of productivity and the improvement of science and technology, the role of horses has been gradually replaced by machines. However, in areas of high altitude, low oxygen or inaccessible and low productivity on the Qinghai-Tibet Plateau, horses are still the main means of transportation and labor. [0003] Areas above 2500 m above sea level are defined as plateaus because this is the altitude at which arterial oxygen saturation begins to decrease (Moore, 2017). The extremely special environment in high-altitude areas, including low temperature, low humidity, strong ultraviolet light, strong r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888C12Q1/6851C12N15/11
CPCC12Q1/6888C12Q1/6851C12Q2600/156C12Q2600/124C12Q2531/113
Inventor 苟潇孔小艳杨舒黎朱莉展亚楠唐琳张晓燕张光荣
Owner FOSHAN UNIVERSITY
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