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Compositions and methods for inhibiting growth of caries-, gingivitis- and halitosis-causing bacteria

A composition and technology for gingivitis, applied in the field of compositions containing tea polyphenols, pH regulators and sugar alcohols, capable of solving problems such as microbial dysbiosis

Inactive Publication Date: 2022-01-18
泡泡奇力有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, under certain conditions, such as under fed or immunocompromised conditions, the microbial ecology can shift to adverse conditions, leading to microbial dysbiosis

Method used

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  • Compositions and methods for inhibiting growth of caries-, gingivitis- and halitosis-causing bacteria
  • Compositions and methods for inhibiting growth of caries-, gingivitis- and halitosis-causing bacteria
  • Compositions and methods for inhibiting growth of caries-, gingivitis- and halitosis-causing bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: At different pHs, the inhibitory effect of tea polyphenols and xylitol on the growth of Streptococcus mutans (Streptococcus mutans)

[0074]Streptococcus mutans (S.mutans) UA159 in the presence of 1% or 10% (w / v) of xylitol or 0.05mg / mL (0.005% (w / v)) or 1mg / mL (0.1% (w / v) In the case of tea polyphenol (polyphenol 60) in v)), growth was carried out at acidic (6.5±0.1), neutral (7.5±0.1) or alkaline (8.5±0.1) pH. Percent inhibition was measured by normalizing the results to S. mutans grown in media with the corresponding pH adjustment. Such as Figure 1A As shown, tea polyphenol alone at a concentration of 0.05 mg / mL showed little inhibitory activity on the growth of S. mutans at pH 6.5, but the inhibitory activity increased with increasing pH. Figure 1A It was also shown that compositions of 1 mg / mL polyphenon 60 similarly exhibited greater activity against the growth of S. mutans at higher pH.

[0075] Figure 1B Show 1% (w / v) or 10% (w / v) xylitol in...

Embodiment 2

[0077] Embodiment 2: At different pHs, the inhibitory effect of tea polyphenols and erythritol on the growth of Streptococcus mutans (Streptococcus mutans)

[0078] Streptococcus mutans (S.mutans) UA159 in the presence of 1% (w / v) or 10% (w / v) erythritol or 0.05mg / mL (0.005% (w / v)) or 1mg / mL ( 0.1% (w / v)) of tea polyphenols (polyphenon 60; Figure 1A ), grown at acidic (6.5±0.1), neutral (7.5±0.1) or basic (8.5±0.1) pH. Percent inhibition was measured by normalizing the results to S. mutans grown in media with the corresponding pH adjustment. Such as Figure 2A As shown, 1% (w / v) or 10% (w / v) erythritol compositions inhibited the growth of S. mutans, with inhibition enhanced by a more alkaline pH. Compositions of 10% (w / v) erythritol showed greater inhibition at all pH values ​​compared to 1% (w / v) erythritol.

[0079] Figure 2B The survival rate of S. mutans in the presence of a composition comprising erythritol and polyphenol 60 at various pHs is shown. At low pH, the...

Embodiment 3

[0080] Embodiment 3: At different pHs, the inhibitory effect of tea polyphenols and xylitol on the growth of Solobacterium moorei

[0081] Morsei bacteria (S.moorei) DSM 22971 in the presence of 1% (w / v) or 10% (w / v) of xylitol or 0.05mg / mL, 0.1mg / mL, 0.2mg / mL or 1mg In the case of tea polyphenols (polyphenon 60) per ml, it grows at acidic (6.5±0.1), neutral (7.5±0.1) or alkaline (8.5±0.1) pH. Percent inhibition was measured by normalizing the results to S. moorei grown in media with the corresponding pH adjustment.

[0082] Such as Figure 3A It was shown that the inhibitory effect of tea polyphenols alone on the growth of S. moorei was pH dependent. At 1 mg / mL polyphenon 60, all pH conditions killed S. moorei beyond detection (ND = not detected). S. moorei was killed beyond detection by 0.2 mg / mL polyphenon 60, pH 7.5 or 8.5, and the survival rate of S. moorei at pH 6.5 was 1.3 %.

[0083] Figure 3B Show 1% (w / v) or 10% (w / v) xylitol in acidic (pH 6.5 ± 0.1), neutral ...

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PUM

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Abstract

The invention provides compositions and methods for topically inhibiting, reducing or preventing growth or biofilm formation of caries-, gingivitis- and / or halitosis-causing bacteria. The composition includes at least about 0.005% (w / v) of tea polyphenols, a pH modulating agent for maintaining a pH of the composition above about 6.5, and at least about 1% (w / v) of a 3-carbon to a 24-carbon sugar alcohol. Also provided are food products or supplements incorporating such compositions.

Description

technical field [0001] The present invention relates to compositions and / or methods for inhibiting bacterial growth and / or biofilm formation leading to dental caries, gingivitis and / or halitosis. In particular, the present invention relates to a composition comprising tea polyphenols, a pH regulator and sugar alcohol for inhibiting bacterial growth and / or biofilm formation leading to dental caries, gingivitis and / or bad breath. Background technique [0002] Dental plaque is a biofilm composed of oral microbial flora that resides on tooth surfaces. The tooth surface is covered by saliva or acquired enamel membrane (AEP) mainly composed of proteins and peptides. Although AEP serves to protect teeth, proteins within AEP can serve as binding sites for various oral bacteria. In turn, these bacteria act as binding sites for other bacteria, leading to the formation of plaque biofilms. [0003] Typically, the plaque microflora is a normal part of the oral microflora. However, un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/352A61P1/02A61P31/04A61Q11/00
CPCA61P1/02A61Q11/00A61K8/9789A61K8/733A61K8/345A61K8/498A61K2800/92A23L33/105A23L33/125A23V2002/00A23L2/52A61K8/19
Inventor 特德·金米苏·奈托
Owner 泡泡奇力有限公司
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