5 results about "Oral Microflora" patented technology

The present application relates to the technical field of biological detection and disease risk prediction, in particular to a periodontal disease risk prediction system based on cardiovascular and oral flora data fusion, comprising a multi-modal data acquisition module, a heterogeneous data preprocessing module, a cross-modal feature fusion module, a double-branch risk prediction model module and a risk grading output module. The multi-modal data acquisition module non-invasively acquires cardiovascular physiological data and oral mucosa swab flora sequencing data of the subject; the preprocessing module denoises and normalizes the time series physiological data, and completes species annotation and abundance correction of the flora data; the cross-modal feature fusion module realizes adaptive alignment and deep fusion of the two types of heterogeneous data through a cross-modal attention mechanism; the double-branch prediction model outputs a risk probability after being trained by a comorbidity correlation data set; and the risk grading module divides the individual risk level in combination with a dynamic threshold. The whole-body cardiovascular and oral flora data are deeply fused to improve the prediction accuracy.

The invention discloses a rapid evaluation method of host caries risk based on Raman spectrum, and relates to the technical field of microbiological detection. Aiming at the problem that in the prior art, it is difficult to rapidly and quantitatively reflect the early metabolic activity of the oral flora, the method introduces a stable isotope signal through heavy water labeling to obtain single-cell Raman spectrum information of the oral flora, and evaluates the metabolic activity of the flora on the basis of a characteristic parameter C-D ratio reflecting the metabolic state of microorganisms in a Raman spectrum, so that the early metabolic activity of the oral flora can be rapidly and quantitatively reflected. Therefore, the judgment of the caries risk of the host is realized. The method comprises the steps of sample collection, flora growth and metabolism law research under different concentration heavy water labeling, and metabolic activity detection under different environmental conditions. By adopting the heavy water concentration of 40%, on the premise that flora growth is not obviously influenced, rapid characterization of metabolic activity can be realized in a short time, the resolution ratio of single cells is high, and disturbance is small. The method provides a new tool for early warning of caries and oral flora metabolism research, and has a wide application prospect.

This invention relates to the field of antimicrobial peptide technology, specifically to an antimicrobial peptide for maintaining oral flora balance, its preparation method, and its application. The antimicrobial peptide for maintaining oral flora balance according to this invention includes any one of the following polypeptides (a)-(e): (a) a polypeptide whose amino acid sequence includes the amino acid sequence shown in SEQ ID NO. 1; (b) an amino acid sequence composed of amino acid residues shown in SEQ ID NO. 1; (c) a polypeptide formed by substituting and / or deleting and / or adding one or more amino acid residues to the amino acid sequence defined in (a) or (b); (d) a polypeptide having 99% or more, 95% or more, 90% or more, 85% or more, or 80% or more homology to the amino acid sequence defined in (a) or (b); (e) a polypeptide obtained by modifying the N-terminus and / or C-terminus of any one of the polypeptides defined in (a)-(d). The antimicrobial peptides of this invention, used to maintain oral flora balance, exhibit antibacterial and bactericidal activity against oral pathogens while not affecting the normal growth of beneficial bacteria. This balance is maintained, protecting gum health and freshening breath. These antimicrobial peptides are suitable for preparing oral antibacterial agents and related oral care products, regulating the balance of the oral microecology, and thus used to prevent and treat oral diseases, especially dental caries, periodontitis, oral mucosal diseases, and oral cancer. The antimicrobial peptides of this invention are relatively short, making chemical synthesis easier and allowing for direct synthesis into high-purity products. They also exhibit clear effects and have wide applications.

The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and / or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and / or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.

The application belongs to the technical field of nanomaterials, and particularly relates to a pH-responsive antibacterial-biomimetic mineralization material and a preparation method and application thereof. + The biomimetic mineralization material is cooperatively assembled by DNA-stabilized silver nanoclusters and amorphous calcium phosphate; the iM + The DNA-stabilized silver nanoclusters are silver nanoclusters synthesized and stabilized by DNA as a template; the iM + The DNA-stabilized silver nanoclusters are silver nanoclusters synthesized and stabilized by DNA as a template; the iM + The DNA is an oligonucleotide containing an i-Motif forming domain, and a nucleotide sequence thereof is shown as SEQ ID NO. 1. The antibacterial-biomimetic mineralization material designed by the application is expected to achieve specific removal of cariogenic plaque without destroying normal oral flora, promote enamel remineralization, and thus achieve the purpose of efficient prevention and treatment of dental caries.