31 results about "Oral Microflora" patented technology

The invention discloses an oral microbial marker composition and application thereof in preparation of a kit for diagnosing high altitude headache, and particularly relates to the technical field of molecular biotechnology detection. A diagnosis model constructed on the basis of oral flora finds that the provided oral flora marker combination can specifically recognize patients with high altitude headache from plateau healthy people. The kit is used for predicting the high-altitude headache illness condition and clinical auxiliary diagnosis, is good in detection specificity and high in sensitivity, can indicate the condition of the high-altitude headache tissue microbial flora, and can guide the clinical diagnosis mode of the high-altitude headache and the adjustment of medication so as to reduce the probability of misdiagnosis and missed diagnosis in clinical diagnosis. The oral flora marker has important application in the aspects of screening and diagnosis of high altitude headache and the like, so that health damage and life risks caused by diseases are reduced.

The application discloses a kind of partition delivery environment response type hydrogel microneedle and its preparation method and application in oral squamous carcinoma treatment.The hydrogel microneedle includes backing layer and the needle tip layer being arranged on the surface of the backing layer, the needle tip layer includes multiple array distribution microneedle tip body, each the needle tip body is connected with the backing layer respectively;Wherein, the backing layer has enzyme response, and the needle tip layer has acidic pH response.The microneedle uses innovative "integration partition design", and two hydrogels with different functions are integrated in single microneedle array: backing layer responds oral flora imbalance microenvironment, needle tip layer responds tumor weak acidic microenvironment.The design can realize partition, accurate, intelligentized synergistic treatment to oral mucosa surface and deep tumor tissue, so as to overcome the technical bottleneck of traditional dosage form in space selectivity, single drug type, release behavior uncontrollable and great systemic toxicity etc.

The invention relates to a dental and / or oral care product comprising between 0.0039% and 0.0078% by weight of nisin establishing and / or maintaining a pH of at least 4.5 in situ. Although said rather low nisin concentration does not provide an anti-bacterial effect, it is surprisingly and advantageously capable of maintaining stable pH values of at least 4.5, thereby preventing destruction of a subject's teeth enamel based on enamel demineralization effects at pH below 4.5, and said low nisin concentration advantageously further avoids dysbacteriosis, i.e. the oral microflora remains balanced, thus not leading to an increase of e.g. periodontitis associated bacteria.

The present invention pertains to a solid food product capable of effectively improving the oral flora in an oral cavity while using a plant-derived powder.　Specifically, the present invention pertains to a solid food product comprising the following components (A) and (B): (A) a plant-derived powder containing a nitrate salt; and (B) one or more salt compounds selected from organic acid salts (B1) and carbonate compounds (B2).

The present application relates to the technical field of biological detection and disease risk prediction, in particular to a periodontal disease risk prediction system based on cardiovascular and oral flora data fusion, comprising a multi-modal data acquisition module, a heterogeneous data preprocessing module, a cross-modal feature fusion module, a double-branch risk prediction model module and a risk grading output module. The multi-modal data acquisition module non-invasively acquires cardiovascular physiological data and oral mucosa swab flora sequencing data of the subject; the preprocessing module denoises and normalizes the time series physiological data, and completes species annotation and abundance correction of the flora data; the cross-modal feature fusion module realizes adaptive alignment and deep fusion of the two types of heterogeneous data through a cross-modal attention mechanism; the double-branch prediction model outputs a risk probability after being trained by a comorbidity correlation data set; and the risk grading module divides the individual risk level in combination with a dynamic threshold. The whole-body cardiovascular and oral flora data are deeply fused to improve the prediction accuracy.

The invention discloses an oral care composition for preventing and treating periodontitis, the oral care composition comprises a compound shown in a formula (I) and oral auxiliary materials, by controlling the concentration or dosage of a component (a) in the oral care composition, the oral care composition can generate the effective drug concentration in the range of 1.35-13mM in the oral cavity after being applied to the oral cavity, and the oral care composition can be used for preventing and treating periodontitis. According to the invention, porphyromonas gingivalis can be more effectively inhibited, and meanwhile, a beneficial bacterium lactobacillus reuteri and the total amount of flora in oral cavities of healthy people are not substantially influenced, so that the oral flora microenvironment and flora imbalance can be effectively improved, and oral related diseases can be further avoided or prevented.

The invention belongs to the field of pancreatic duct adenocarcinoma prediction, and provides a pancreatic duct adenocarcinoma prediction method and system based on oral flora. The pancreatic ductal adenocarcinoma prediction method based on oral flora comprises the following steps: acquiring relative abundance information of each biomarker in a potential biomarker set for diagnosing pancreatic ductal adenocarcinoma of a to-be-detected person; using the relative abundance information of each biomarker in the biomarker set and a pre-trained multivariate statistical model to obtain a probability value of suffering from pancreatic ductal adenocarcinoma; the method comprises the following steps: performing microbiome difference analysis on saliva, duodenal juice and pancreatic tissue samples of a pancreatic ductal adenocarcinoma patient group and a pancreatic benign disease patient group, and taking an intersection of differential bacteria in the samples to obtain a potential biomarker set for diagnosing the pancreatic ductal adenocarcinoma.

The invention discloses a non-invasive colorectal cancer early screening and diagnosis method and electronic equipment. The method comprises the following steps: collecting excrement, saliva, a blood sample and a standardized tongue image of a subject; species abundance information of intestinal flora and oral flora is obtained through metagenome sequencing, and the tumor marker level is obtained through blood detection; and inputting the multi-modal data into a pre-trained colorectal cancer risk prediction model, and outputting a risk probability. The model is obtained by training based on a machine learning algorithm by adopting a training data set containing healthy persons and patients, the architecture of the model adopts a late fusion strategy, clinical, flora and tongue picture features are respectively processed through three sub-models of logistic regression, a gradient boosting decision tree and a convolutional neural network, dynamic fusion is performed by utilizing a Self-Attention mechanism, and finally a diagnosis result is output. According to the method, through multi-modal information fusion, the screening accuracy, the standardization degree and the patient compliance are remarkably improved.

The application discloses an oral care composition and use, which comprises a compound shown in formula (I) and an oral auxiliary material, and by controlling the concentration or amount of component (a) in the oral care composition, the oral care composition can generate a drug effective concentration in the range of 1.35-13 mM in the oral cavity after being applied to the oral cavity, can more effectively inhibit Porphyromonas gingivalis, has no substantial influence on Lactobacillus reuteri and the total amount of the bacterial flora in the oral cavity of healthy people, and thus can effectively improve the microenvironment of the oral bacterial flora and the imbalance of the bacterial flora, and further avoid or prevent oral diseases.

The invention discloses a rapid evaluation method of host caries risk based on Raman spectrum, and relates to the technical field of microbiological detection. Aiming at the problem that in the prior art, it is difficult to rapidly and quantitatively reflect the early metabolic activity of the oral flora, the method introduces a stable isotope signal through heavy water labeling to obtain single-cell Raman spectrum information of the oral flora, and evaluates the metabolic activity of the flora on the basis of a characteristic parameter C-D ratio reflecting the metabolic state of microorganisms in a Raman spectrum, so that the early metabolic activity of the oral flora can be rapidly and quantitatively reflected. Therefore, the judgment of the caries risk of the host is realized. The method comprises the steps of sample collection, flora growth and metabolism law research under different concentration heavy water labeling, and metabolic activity detection under different environmental conditions. By adopting the heavy water concentration of 40%, on the premise that flora growth is not obviously influenced, rapid characterization of metabolic activity can be realized in a short time, the resolution ratio of single cells is high, and disturbance is small. The method provides a new tool for early warning of caries and oral flora metabolism research, and has a wide application prospect.

This invention relates to the field of antimicrobial peptide technology, specifically to an antimicrobial peptide for maintaining oral flora balance, its preparation method, and its application. The antimicrobial peptide for maintaining oral flora balance according to this invention includes any one of the following polypeptides (a)-(e): (a) a polypeptide whose amino acid sequence includes the amino acid sequence shown in SEQ ID NO. 1; (b) an amino acid sequence composed of amino acid residues shown in SEQ ID NO. 1; (c) a polypeptide formed by substituting and / or deleting and / or adding one or more amino acid residues to the amino acid sequence defined in (a) or (b); (d) a polypeptide having 99% or more, 95% or more, 90% or more, 85% or more, or 80% or more homology to the amino acid sequence defined in (a) or (b); (e) a polypeptide obtained by modifying the N-terminus and / or C-terminus of any one of the polypeptides defined in (a)-(d). The antimicrobial peptides of this invention, used to maintain oral flora balance, exhibit antibacterial and bactericidal activity against oral pathogens while not affecting the normal growth of beneficial bacteria. This balance is maintained, protecting gum health and freshening breath. These antimicrobial peptides are suitable for preparing oral antibacterial agents and related oral care products, regulating the balance of the oral microecology, and thus used to prevent and treat oral diseases, especially dental caries, periodontitis, oral mucosal diseases, and oral cancer. The antimicrobial peptides of this invention are relatively short, making chemical synthesis easier and allowing for direct synthesis into high-purity products. They also exhibit clear effects and have wide applications.

The invention discloses a micro-ecological protective oral cleaning composition for whole-course control of dental calculus and application of the micro-ecological protective oral cleaning composition, and belongs to the technical field of oral care products. The composition contains citrate, a multienzyme mixture (at least two of lysozyme, xylanase and chymotrypsin) and a matrix additive. Citrate is chelated with calcium ions to soften and dissolve calcified dental calculus; enzymolysis of a multi-enzyme mixture inhibits early bacterial attachment and sediment accumulation and cooperates with citrate to decompose calcified dental calculus; the matrix additive ensures stable release of active ingredients. The components are synergistic, the whole process from the initial stage of dental calculus formation to calcification maturation intervenes, inhibits deposition and dissolves a calcification structure, and meanwhile, the composition can protect the micro-ecology of the oral cavity and has no obvious destructive effect on oral flora. The composition is applied to preparation of oral care products, can solve the problems of one-sided cleaning effect, poor hidden area effect and dysbacteriosis caused by sterilization of existing products, achieves the dual purposes of whole-course dental calculus control and micro-ecological maintenance, and is wide in application prospect.

The application discloses application of Geotrichum candidum as a biomarker in heart failure diagnosis. The application studies the correlation between oral flora and heart failure, and finds through detection of clinical samples that the Geotrichum candidum can be used as an independent biomarker for diagnosing heart failure. Meanwhile, the application provides a biomarker combination comprising the Geotrichum candidum, and the biomarker combination has high heart failure diagnosis efficiency. The application can realize early diagnosis of heart failure, guide clinicians to provide a prevention or treatment scheme for a subject, and thus better intervene in the disease process of heart failure occurrence and development.

To provide an oral composition that selectively and efficiently promotes growth of Neisseria and / or Rothia species, non-pathogenic bacteria present in the oral microbiota, enabling effective improvement of the oral microbiota.SOLUTION: An oral composition comprising the following components (A) and (B): (A) a nitrate ion-supplying compound and (B) a chlorophyll metal complex salt derivative.SELECTED DRAWING: None

The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and / or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and / or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.

The invention relates to the technical field of probiotics, in particular to pediococcus pentosaceus with the effect of preventing or treating decayed teeth and periodontal diseases as well as a preparation and application of the pediococcus pentosaceus. The pediococcus pentosaceus is preserved in China General Microbiological Culture Collection Center (CGMCC) on May 15, 2023, the preservation address is No. 3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No. 27356. The pediococcus pentosaceus provided by the invention can remarkably inhibit growth and reproduction of oral pathogens such as streptococcus mutans, porphyromonas gingivalis, fusobacterium nucleatum, actinomycetes viscosity, actinobacillus actinomycetes and the like, is beneficial to oral flora balance, and can be widely used for preventing or treating oral diseases such as decayed teeth and periodontitis.

To provide an oral composition that selectively and effectively promotes the growth of bacteria belonging to the genus Neisseria within the oral microbiota.SOLUTION: An oral composition comprises the following components (A) and (B): (A) a nitrate ion-supplying compound, and (B) an organic acid salt in an amount of 0.4 mass% or more and 18 mass% or less.SELECTED DRAWING: None

To provide a solid food product capable of effectively improving the oral flora in an oral cavity while using a plant-derived powder.SOLUTION: The present invention pertains to a solid food product comprising the following components (A) and (B): (A) a plant-derived powder containing a nitrate salt; and (B) one or more salt compounds selected from organic acid salts (B1) and carbonate compounds (B2).SELECTED DRAWING: None

To provide an oral microbiota improver that selectively and efficiently promotes growth of Neisseria and / or Rothia species in the oral microbiota, enabling effective improvement of the oral microbiota.SOLUTION: An oral microbiota improver comprising, as an active ingredient, one or two selected from chlorophyll metal complex salt derivatives and chlorophyll derivatives.SELECTED DRAWING: None

To provide a material effective for enhancing the content ratio of bacteria belonging to the genus Neisseria and the genus Actinomyces in the oral cavity.SOLUTION: An oral microbiota improver comprises, as active ingredients, one or more salt compounds selected from organic acid salts, bicarbonates, and carbonates, and a nitrate ion-supplying compound.SELECTED DRAWING: None

To provide an oral composition that selectively and efficiently promotes growth of Neisseria and / or Rothia species, non-pathogenic bacteria present in the oral microbiota, enabling effective improvement of the oral microbiota.SOLUTION: An oral composition comprising the following components (A) and (B): (A) a nitrate ion-supplying compound and (B) glycyrrhetinic acid, the composition containing sodium lauryl sulfate in an amount of 0.1 mass% or less or containing no sodium lauryl sulfate.SELECTED DRAWING: None

The present application relates to the technical field of probiotics, in particular to a Pediococcus pentosaceus with the effect of preventing or treating dental caries and periodontal disease, and a preparation and application thereof. The Pediococcus pentosaceus has been preserved in the China General Microbiological Culture Collection Center on May 15, 2023, and the address of the preservation center is No. 1, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No. 27356. The Pediococcus pentosaceus provided by the present application can significantly inhibit the growth and reproduction of oral pathogenic bacteria such as Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum, Actinomyces viscosus and Aggregatibacter actinomycetemcomitans, is conducive to the balance of oral flora, and can be widely used for preventing or treating oral diseases such as dental caries and periodontitis.

The present invention relates to a composition for oral cavity, which can selectively and effectively promote the growth of bacteria belonging to the genus Neisseria and / or bacteria belonging to the genus Rothia, which are non-pathogenic bacteria in the oral flora, and thereby can effectively improve the oral flora.　The present invention provides a composition for oral cavity, which comprises the following components (A) and (B): (A) a nitrate ion supply compound and (B) a chlorophyll metal complex salt derivative.

The invention provides an oral preparation for inhibiting porphyromonas gingivalis as well as a preparation method and application of the oral preparation. The preparation comprises an effective component and a medical auxiliary material, wherein the effective component is a compound as shown in a formula (1) or a pharmaceutically acceptable salt thereof. The preparation disclosed by the invention can effectively inhibit or reduce harmful bacteria such as porphyromonas gingivalis and the like, does not generate adverse effects on beneficial bacteria and / or the whole oral flora, and can regulate the microenvironment of the oral flora, promote proliferation of oral mucosa epithelial cells and improve oral diseases or conditions.

The application belongs to the technical field of nanomaterials, and particularly relates to a pH-responsive antibacterial-biomimetic mineralization material and a preparation method and application thereof. + The biomimetic mineralization material is cooperatively assembled by DNA-stabilized silver nanoclusters and amorphous calcium phosphate; the iM + The DNA-stabilized silver nanoclusters are silver nanoclusters synthesized and stabilized by DNA as a template; the iM + The DNA-stabilized silver nanoclusters are silver nanoclusters synthesized and stabilized by DNA as a template; the iM + The DNA is an oligonucleotide containing an i-Motif forming domain, and a nucleotide sequence thereof is shown as SEQ ID NO. 1. The antibacterial-biomimetic mineralization material designed by the application is expected to achieve specific removal of cariogenic plaque without destroying normal oral flora, promote enamel remineralization, and thus achieve the purpose of efficient prevention and treatment of dental caries.

The invention belongs to the field of development and application of probiotics for oral care, and discloses a method for screening probiotics with a function of preventing and treating bacterial plaque gingivitis. The preparation method comprises the following steps: separating oral microorganisms of people with healthy oral cavities, further carrying out confrontation culture on the oral microorganisms and gingivitis pathogenic bacteria porphyromonas gingivalis or actinobacillus actinomycetes, and screening to obtain strains with antagonistic action on the gingivitis pathogenic bacteria, so as to obtain the probiotics with the function of preventing and treating the bacterial plaque gingivitis. The screened probiotics can be subjected to species identification by means of strain morphological structure analysis, physiological and biochemical characteristic identification, 16SrDNA sequence analysis and the like. The method for screening the probiotics with the function of preventing and treating the bacterial plaque gingivitis, disclosed by the invention, has the characteristics of simplicity, convenience, high efficiency, high specificity and high practicability, and the screened probiotics are non-oral external environment source strains, are high in adaptability to the oral environment, do not damage original oral flora and are suitable for developing oral care products.

[Problem] The purpose of the present invention is to provide a composition capable of inhibiting diseases other than oral diseases. [Solution] The present invention is a growth inhibitor for Fusobacterium bacteria, and contains cyclodextran and / or a derivative thereof. The inhibitory effect of Fusobacterium bacteria contributes to the treatment and prevention of ulcerative colitis, cirrhosis, obesity, colon cancer, esophageal cancer, oral cancer, breast cancer, ovarian cancer, cervical cancer, oral squamous cell carcinoma, colorectal cancer, pancreatic ductal adenocarcinoma, premature birth, endometriosis, and the like.

The invention relates to the technical field of oral microbiological analysis, and discloses an oral microbiological analysis system, which is used for optimizing the accuracy of alteration detection by regulating and controlling the pH value fluctuation based on the metabolic activity of specific oral microbes in a saliva sample, and collecting and analyzing oral flora gene segments. The classification precision is improved by regulating and controlling the species annotation error rate in the data analysis process, the deviation caused by individual difference is reduced by regulating and controlling the variable weight in the analysis model according to interaction signals of host cells and microorganisms, and the classification accuracy is improved according to the stability performance of microbial communities at different temperatures. According to the scheme provided by the embodiment of the invention, the problem of how to regulate and control the fluctuation of the pH value in the saliva sample according to the metabolic activity of specific oral microorganisms so as to solve the problem of flora imbalance detection accuracy can be solved.

Relates to the technical field of oral medicine and oral medical products, in particular to a targeted nano-enzyme antibacterial agent with an oral flora level self-adaptive regulation function and a preparation method of the targeted nano-enzyme antibacterial agent. Specifically, a nitrogen-doped zeolite imidazate framework material is used as a carrier, and the bimetallic monatomic nano-enzyme is prepared through a pyrolysis method; the antibacterial peptide is used as a surface anchoring body and is modified on the surface of the nano-enzyme, so that the multifunctional nano-enzyme with high targeting colonization capability, efficient antibacterial biofilm and antibacterial effect is obtained. The invention also relates to a pharmaceutical composition, an antibacterial agent and an oral care product containing the nano-enzyme.

The present application relates to a kind of inhibiting gingival senile bleeding, repair gingival and maintain oral flora balance composition, belong to oral care technical field.The inhibiting gingival senile bleeding, repair gingival and maintain oral flora balance composition of the present application includes the following components: ECMP, white and extract, non-sertone.The inhibiting gingival senile bleeding, repair gingival and maintain oral flora balance composition of the present application has significantly improved clotting time, promotes the repair of gingival fibroblast, inhibits the expression of senile gene p53 and p21, and has certain proliferation effect on oral probiotics.