Method for evaluating palatability of coated enrofloxacin by measuring encapsulation efficiency
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of encapsulation rate and palatability, which is applied in the field of medicine and chemical industry, can solve the problems affecting pig feed intake and achieve good reproducibility, maintain temperature and stirring speed, high stability and repeatability
Pending Publication Date: 2022-01-21
XINCHANG HEBAO BIOTECH
View PDF15 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, the coating effect of enrofloxacin will directly affect the feed intake of pigs
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0024] Use reagents:
[0025] Acetonitrile;
[0026] 2. Triethylamine;
[0027] 3. Phosphoric acid;
[0028] 4. Purification water;
[0029] 5. Sodium hydroxide;
[0030] 6. Sodium phosphate.
[0031] Pre-tuning reagent:
[0032] 1. Phosphate solution: Take 6.805 g of sodium phosphate and 0.88 g of sodium hydroxide, add water to 1000 mL, and adjust the pH to 6.86 with 2 mol / L of sodium hydroxide solution or dilute phosphoric acid solution.
[0033] 2. Mobile phase: The phosphoric acid solution of 0.025 mol / L was adjusted by triethylamine to a pH of 3.0, and then the acetonitrile and the phosphoric acid solution were mixed in volume ratio of 17:83.
[0034] Use the instrument:
[0035] 1. Generally used glassware commonly used in the laboratory;
[0036] 2. Dissolution meter;
[0037] 3. High performance liquid chromatography.
[0038] Experimental steps:
[0039] a) Preparation of sample solution:
[0040] A 500.0 ml of a phosphate solution was quantified and placed in a disso...
Embodiment 2
[0058] Add 1.016 g of the coated Ennovia (Xinchang and Baosheng Technology Co., Ltd.) and stirring. Others in the same embodiment.
[0059] The calculation results are shown in Table 2 below:
[0060]
[0061] Table 2 Embodiment of the encapsulation rate test results
Embodiment 3
[0063] Takenno Sand 0.5mg, 1.0 mg and 1.5 mg of 6 copies, and added to the dissolution cup, and the recovery measurement was carried out according to the establishment method, and the results were as follows:
[0065] Table 3 method of recovery rate test results
[0066] Referring to Table 3, the average recovery rate is between 78.9-98.7%, between 1.9-3.5%, indicating that this method has better recovery, stability and repetition, fully meet the packaged Enno Sand Daily inspection requirements for star package levels.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
recovery rate
aaaaa
aaaaa
coefficient of variation
aaaaa
aaaaa
Login to view more
Abstract
The invention discloses a method for evaluating palatability of coated enrofloxacin by measuring the encapsulation efficiency. The method comprises the following steps: a) preparing a sample solution, namely dissolving to-be-tested coated enrofloxacin by adopting a phosphate solution, performing stirring and filtering filtrate to obtain the sample solution, and recording the concentration as C sample; b) preparing a reference substance solution, namely dissolving standard enrofloxacin by adopting a phosphate solution, performing stirring to obtain the reference substance solution, and recording the concentration as C reference; c) carrying out high performance liquid chromatography detection: respectively injecting the sample solution prepared in the step a) and the reference substance solution prepared in the step b) into a high performance liquid chromatograph, recording a chromatogram, respectively recording the peak area A sample of the sample solution and the peak area A reference of the reference substance solution according to an external standard method, and d) carrying out calculating. According to the method, the palatability of the coated enrofloxacin is evaluated by measuring the encapsulation efficiency, and the recovery rate, stability and repeatability of the test method are relatively high, so that the quality control of the coated enrofloxacin product can be realized.
Description
[Technical field] [0001] The present invention relates to the technical field of pharmaceutical chemical technology, in particular, a technical field of evaluating a method of assessing the preparation of Enovoroxacin by determination of the encapsulation rate. 【Background technique】 [0002] Enno Shaxing, also known as ethylcyclopropoxicle or Ethifier star, system named 1-cyclopropyl -7- (4-ethyl-1-piperazinyl) -6-fluoro-1, 4 - Dihydro-4-oxo-3-quinoline carboxylic acid is a special antibacterial drug specified by the designated third-generation quinolones. Although Enoviaxia is often used in livestock and aquatic products, it is hardly used in pig mouth due to taste. In order to solve this phenomenon, people will be treated by Enoviarddra. However, the package of the package of Ennohaxard will directly affect the food's feeding effect. Therefore, the method of coating the effect of Ennohaxard is very urgent. [Summary] [0003] It is an object of the present invention to solve t...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more