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Biomarker for auxiliary diagnosis of gastric cancer and application thereof

A technology for biomarkers and auxiliary diagnosis, which is applied in the fields of biomaterial analysis, biochemical equipment and methods, and microbial determination/inspection, etc. It can solve the problems of lower overall survival rate of NAMPT overexpression and achieve good specificity and sensitivity Effect

Inactive Publication Date: 2022-01-28
ZHEJIANG CANCER HOSPITAL
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Problems solved by technology

Zhao W and others published a paper in "Mol Med Rep" High glucose promotes gastric cancer chemoresistance in vivo and in vitro. It also showed that NAMPT is highly expressed in gastric cancer tissues, and the overall survival rate of NAMPT high expression is reduced

Method used

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  • Biomarker for auxiliary diagnosis of gastric cancer and application thereof
  • Biomarker for auxiliary diagnosis of gastric cancer and application thereof
  • Biomarker for auxiliary diagnosis of gastric cancer and application thereof

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Embodiment Construction

[0033] The present invention will be further described below in combination with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0034] Inclusion criteria for research objects: ⑴Patients with newly diagnosed gastric cancer confirmed by pathology; ⑵Can be operated on, and postoperative tissue samples can be obtained; ⑶Have complete clinical and pathological data; ⑷Hepatic and renal functions are normal, and the body mass index (BMI) is 20.00 ~30.00kg / m2. Exclusion criteria: (1) Previous or simultaneous malignant tumors of other organs; (2) Those w...

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Abstract

The invention belongs to the field of biological medicine detection, and particularly relates to a biomarker for auxiliary diagnosis of gastric cancer and application of the biomarker, nicotinamide phosphoribosyltransferase is adopted as the marker for auxiliary diagnosis of gastric cancer and is used for preparing a diagnostic reagent or kit for detecting gastric cancer. Wherein a sample used for detecting the gastric cancer by the diagnostic reagent or the kit is serum, plasma or body fluid. The biomarker has the advantages that the drawn ROC curve shows that compared with CEA and CA19-9, the NAMPT has better specificity and sensitivity, and an experimental basis is provided for taking the NAMPT as a gastric cancer early-stage risk prediction index. And the positive rate of the three combined auxiliary diagnosis of the gastric cancer is 90%. The level of NAMPT in serum of a gastric cancer patient before an operation is detected by adopting an enzyme-linked immunosorbent assay, and retrospective analysis finds that the survival rate of the gastric cancer patient with the high NAMPT level before the operation is remarkably poor. This indicates a potential marker for poor prognosis of high NAMPT gastric cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine detection, and in particular relates to a biomarker for auxiliary diagnosis of gastric cancer and its application. Background technique [0002] Globally, gastric cancer (GC) is one of the most common malignant tumors of the digestive system. About 95% of gastric cancers are adenocarcinomas, and the average survival time of untreated patients is about 1 year. The second and third place of death, a serious threat to human health. my country is a country with a large incidence of gastric cancer, accounting for about 50% of the global incidence, and the 5-year survival rate of gastric cancer patients is only 20-30%. The main reason is that the clinical characteristics and biological behavior of gastric cancer are not obvious in the early stage of the disease, and the degree of malignancy is high, and it is prone to metastasis. There is a lack of effective screening and cure methods. Therefore, most patien...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/543G01N33/573G01N33/574
CPCC12Q1/6886G01N33/573G01N33/57446G01N33/543G01N2333/91142C12Q2600/158C12Q2600/118
Inventor 杨绍雪周菁楠徐志远樊璠孙薇许颂霄潘志文陈勇毅
Owner ZHEJIANG CANCER HOSPITAL
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