Coding microneedle patch and preparation method and application thereof

A micro-needle patch and micro-needle technology, applied in the field of coding micro-needle patch and its preparation, can solve the problems of single loaded substance, complicated process, unreasonable administration method, etc., and achieve the effect of unique concept and simple method

Pending Publication Date: 2022-01-28
赵超超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent literature (CN111544756A) reports a painless dissolvable microneedle loaded with a photosensitizer and a microneedle array and a preparation method to solve the problem of unreasonable drug delivery in photodynamic therapy; patent literature (CN104117137A) reports a capsule Formula hollow drug-loaded microneedle array and preparation method thereof to solve the problem of fusion of delivered drugs and biomaterials
After searching carefully, the inventor found that most of the current studies use microneedles to extract interstitial fluid, and then need to go through a complex extraction process and perform a series of complex reactions in vitro to finally determine the content of the analyte. This operation has a complicated process , the problem of low efficiency; in addition, the arrangement of the microneedles is also multi-square, and the loading material is single

Method used

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  • Coding microneedle patch and preparation method and application thereof
  • Coding microneedle patch and preparation method and application thereof
  • Coding microneedle patch and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] see Figure 1 ~ Figure 3 , a coded microneedle patch, comprising a microneedle base 1, a microneedle body 3, the microneedle body is located on the microneedle base, the microneedle body 5, the microneedle body 6 , the microneedle body 7 is used to carry protein molecules that recognize three inflammatory factors TNF-α, IL-1 and IL-6, and the coded microneedle patch identifies the types of the above-mentioned protein molecules through the difference in dye color, The dye forms a corresponding color barcode 2 on the microneedle base at the bottom of the microneedle body.

[0044] In this embodiment, the color barcode includes a first color barcode 21, a second color barcode 22, and a third color barcode 23; the microneedle body includes a first microneedle body 31 and a second microneedle body 32 , the third microneedle body 33 .

[0045] In this embodiment, the material of the microneedle body is polyethylene glycol diacrylate (Poly(ethylene glycol) diacrylate, PEGDA) w...

Embodiment 2

[0056] see Figure 4 , is another embodiment of the coded microneedle patch of the present invention. In this embodiment, the coded microneedle patch also includes a microneedle base 1 and a microneedle body (not shown in the figure), the microneedle body is made of polymethacrylic acid, and the height of the microneedle is 500 μm. The difference is that the size of the microneedle array is adjusted. It can be seen from the figure that there are 10 color barcodes 2, correspondingly, 10 different protein molecules can be contained, and the types of protein molecules contained in the microneedle can be quickly distinguished by the difference in color.

[0057] In this example, the preparation method of the coded microneedle patch is the same as that in Example 1. Quantitative analysis of 10 different biomarkers can be achieved by using corresponding detection methods.

[0058] Therefore, in this embodiment, the number of biomarkers detected can be flexibly adjusted by changin...

Embodiment 3

[0060] see Figure 5 , is another embodiment of the encoded microneedle patch of the present invention. In this embodiment, the coded microneedle patch also includes a microneedle base 1 and a microneedle body 2, the microneedle body 2 is made of sodium carboxymethyl cellulose, and the height of the microneedle is 600 μm, the difference is that , the dye is not at the bottom of the microneedle body, but on the microneedle body.

[0061] Also, the types of protein molecules carried by the microneedles can be quickly distinguished by the different colors of the dyes.

[0062] As for the specific implementation of the preparation method and quantitative analysis of the microneedle body, refer to Example 1.

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Abstract

The invention discloses a coding microneedle patch and a preparation method and application thereof. The coding microneedle patch comprises a microneedle base and a microneedle body, the microneedle body is positioned on the microneedle base and is used for entrapping a protein molecule for identifying a biomarker; the protein molecule is one or more of an antibody, an antigen or a biological enzyme; according to the present invention, the types of the protein molecules are identified through the difference of the signal molecules or the microneedle body arrays, and the quantitative detection of the biomarkers is achieved through the specific binding of the biomarkers and the protein molecules, such that the simultaneous qualitative and quantitative detection of the plurality of biomarkers is achieved, and the wide application prospect is provided.

Description

technical field [0001] The invention belongs to the field of biomolecular detection, and more specifically relates to a coded microneedle patch and its preparation method and application. Background technique [0002] At present, blood tests or urine tests are usually used to determine biomarkers in the human body, but blood tests will damage the skin and cause pain, and blood tests or urine tests need to be performed by professionals, there is a risk of infection, and patients will have certain symptoms. Resist mentality. [0003] Skin interstitial fluid is a liquid that exists in the interstitium of cells and is the medium for material exchange between blood and surrounding tissues. Except for the absence of macromolecular proteins, other components are basically the same as those in plasma, including glucose, cholesterol and ascorbic acid. small molecules and various growth factors, inflammatory factors, antibodies and other proteins. In recent years, the use of microne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/543G01N33/533G01N21/64G01N21/65G01N21/31G01N21/25
CPCG01N33/6869G01N33/6863G01N33/54313G01N33/533G01N21/6428G01N21/6486G01N21/65G01N21/31G01N21/25G01N2333/5412G01N2333/545G01N2333/525
Inventor 杨圆胥玲玲赵超超李舟
Owner 赵超超
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