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Method for modifying and immobilizing heparin on surfaces of blood perfusion resin microspheres and adsorbent prepared thereby

A technology of resin microspheres and surface modification, which is applied in the direction of blood diseases, selective adsorption, chemical instruments and methods, etc., can solve the problems of short coagulation time and insufficient improvement of blood compatibility, so as to avoid coagulation and excellent anticoagulant performance , reduce the effect of coagulation

Pending Publication Date: 2022-02-15
YUNNAN NORMAL UNIV
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Problems solved by technology

[0004] In view of this, this solution aims to overcome at least one deficiency in the prior art, provide a new simple and effective method for modifying and immobilizing heparin on the surface of hemoperfusion resin microspheres, and solve the problem of the existing surface modification technology on the blood phase. Technical problems of insufficient capacitive improvement and short coagulation time

Method used

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  • Method for modifying and immobilizing heparin on surfaces of blood perfusion resin microspheres and adsorbent prepared thereby
  • Method for modifying and immobilizing heparin on surfaces of blood perfusion resin microspheres and adsorbent prepared thereby
  • Method for modifying and immobilizing heparin on surfaces of blood perfusion resin microspheres and adsorbent prepared thereby

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Embodiment 1

[0034] Add 1.5g shellac to 150mL ammonia solution with a concentration of 0.5mol / L, and stir to dissolve. Continue to add 150 mg of heparin sodium to prepare 150 mL of ammonia solution containing 1.0% (g / mL) shellac and 1 g / L heparin sodium. Add 100mL hemoperfusion resin microspheres into the solution to soak, and stir slowly for 2 hours, which is conducive to the diffusion of shellac and heparin sodium into the pores of the adsorbent. Then, it was heated to 80° C. in a fume hood until the ammonia solution was completely evaporated to obtain a shellac surface-modified adsorbent immobilized with heparin. Finally, the adsorbent is collected by filtration, washed with purified water, and dried to obtain the finished adsorbent.

Embodiment 2

[0036]Add 0.75g of shellac to 150mL of ammonia solution with a concentration of 0.2mol / L, and stir to dissolve. Continue to add 75 mg of heparin sodium to prepare 150 mL of ammonia solution containing 0.5% (g / mL) shellac and 0.5 g / L heparin sodium. Add 100mL hemoperfusion resin microspheres into the solution to soak, and stir slowly for 1 hour, which is conducive to the diffusion of shellac and heparin sodium into the pores of the adsorbent. Then, it was heated to 80° C. in a fume hood until the ammonia solution was completely evaporated to obtain a shellac surface-modified adsorbent immobilized with heparin. Finally, the adsorbent is collected by filtration, washed with purified water, and dried to obtain the finished adsorbent.

Embodiment 3

[0038] Add 0.30 g of shellac to 150 mL of ammonia solution with a concentration of 0.2 mol / L, and stir to dissolve. Continue to add 75 mg of heparin sodium to prepare 150 mL of ammonia solution containing 0.2% (g / mL) shellac and 0.5 g / L heparin sodium. Add 100mL hemoperfusion resin microspheres into the solution to soak, and stir slowly for 1 hour, which is conducive to the diffusion of shellac and heparin sodium into the pores of the adsorbent. Then, it was heated to 70° C. in a fume hood until the ammonia solution was completely evaporated to obtain a shellac surface-modified adsorbent immobilized with heparin. Finally, the adsorbent is collected by filtration, washed with purified water, and dried to obtain the finished adsorbent.

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Abstract

The invention belongs to the technical field of blood purification, and discloses a method for modifying and immobilizing heparin on the surfaces of blood perfusion resin microspheres and an adsorbent prepared thereby. The method comprises the following steps: soaking resin microspheres in an ammonia water solution containing shellac and heparin salt, heating and evaporating, so that the shellac is attached to the outer surfaces of the resin microspheres and the surfaces of holes of the resin microspheres, and hydrophilic modification and heparin immobilization are realized. According to the scheme, the shellac is dissolved in an ammonia water solution and adheres to the surfaces of holes of the resin microspheres to achieve modification in the process of heating and evaporating ammonia water, and the hydrophilic ends of shellac molecules are exposed to the surfaces of the holes to improve the blood compatibility of the shellac molecules; and meanwhile, the immobilized heparin has excellent anti-coagulation performance, and the blood coagulation phenomenon occurring when blood makes contact with the resin microspheres can be reduced. The preparation method is simple and effective, is suitable for various resin type blood perfusion products clinically used at present, and improves the safety of clinical application.

Description

technical field [0001] The solution belongs to the technical field of blood purification, and specifically relates to a method for modifying and immobilizing heparin on the surface of hemoperfusion resin microspheres and an adsorbent prepared therefrom. Background technique [0002] Hemoperfusion is a blood purification technique that introduces the patient's blood into a perfusion device equipped with adsorbents, and removes exogenous or endogenous toxins, drugs or metabolic wastes in the blood that cannot be removed by dialysis through adsorption. As one of the basic treatment modes of blood purification, hemoperfusion technology has developed rapidly in the past ten years, and its application range has become more and more extensive. Resin microspheres are currently the most common hemoperfusion adsorbent on the market. They are mainly used to rescue drug and poison poisoning, and can also be used in combination with hemodialysis to remove medium and large molecule toxins...

Claims

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Application Information

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IPC IPC(8): B01J20/28B01J20/26B01J20/32B01J20/30B01D15/08A61K31/727A61P7/02
CPCB01J20/28021B01J20/26B01J20/3208B01J20/28014B01D15/08A61K31/727A61P7/02
Inventor 张旭锋
Owner YUNNAN NORMAL UNIV
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