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Isolation cross-linked gel, preparation method and application

A cross-linking gel and cross-linking reaction technology, applied in the field of biomedicine, can solve the problems of poor cohesion, poor radiation tolerance, and insufficient retention time, and achieve safe injection process, excellent morphological stability and radiation resistance. The effect of excellent biocompatibility

Pending Publication Date: 2022-03-11
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cohesion of hyaluronic acid gel is strong, so that the gel can maintain a certain shape in the body, but the influence of radiation on the gel makes the hyaluronic acid gel easy to be degraded, and the retention time in the body is not long enough; gelatin gel cohesion Inferior but more radiation resistant, therefore, cross-linked hyaluronic acid gelatin gels resistant to radiation degradation are required, and no such products have been reported so far

Method used

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  • Isolation cross-linked gel, preparation method and application
  • Isolation cross-linked gel, preparation method and application
  • Isolation cross-linked gel, preparation method and application

Examples

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preparation example Construction

[0054] The invention provides a method for preparing a cross-linked gel for isolation, comprising the steps of:

[0055] adding hyaluronic acid or its salt, and gelatin to the alkaline solution to obtain a first solution;

[0056] mixing the first solution with a crosslinking agent to obtain a second solution;

[0057] The second solution is subjected to a cross-linking reaction, and the cross-linking reaction product is swollen to obtain a cross-linked gel for isolation.

[0058] The "crosslinking agent" is also called a bridging agent, which forms a bridge bond between polymer molecular chains and becomes an insoluble substance with a three-dimensional structure.

[0059] The hyaluronic acid or its salt can be hyaluronic acid and its salt known to those skilled in the art, such as hyaluronic acid, and the hyaluronic acid salt is preferably a hyaluronic acid metal salt, such as sodium hyaluronate, potassium hyaluronate, etc. .

[0060] The alkaline solution can be an alkal...

Embodiment 1

[0091] Dissolve 0.4g of gelatin in 10mL of 1wt% sodium hydroxide solution. The molecular weight of gelatin is 200kDa. After dissolving completely, add 2g of sodium hyaluronate. The molecular weight of sodium hyaluronate is 3000kDa. The mass ratio of sodium hyaluronate to gelatin is 5: 1. Add 48mg of 1,4-butanediol diglycidyl ether, the amount of 1,4-butanediol diglycidyl ether is 2% of the sum of the mass of sodium hyaluronate and gelatin, stir well and put it in a water bath Cross-linking reaction at 30°C for 10 hours in a pot. After the cross-linking reaction is over, cut the cross-linking reaction product into small pieces and place in a phosphate buffer solution (1L phosphate buffer solution: 9g sodium chloride, 0.22g disodium hydrogen phosphate , 0.05g sodium dihydrogen phosphate, and water for injection to make up the balance) dialyzed and swelled the resulting gel block to granulate through a 60-mesh sieve to obtain cross-linked sodium hyaluronate and gelatin with a tota...

Embodiment 2

[0093] The difference between Example 2 and Example 1 is only that the mass ratio of sodium hyaluronate to gelatin is 10:1, and the rest of the conditions are the same.

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Abstract

The invention discloses a cross-linked gel for isolation. The cross-linked gel is prepared by a method comprising the following steps: adding hyaluronic acid or a salt thereof and gelatin into an alkaline solution to obtain a first solution; mixing the first solution with a cross-linking agent to obtain a second solution; and carrying out a cross-linking reaction on the second solution, and swelling a cross-linking reaction product to obtain the cross-linked gel for isolation. The cross-linked gel for isolation has excellent morphological stability and radiation resistance, and is more suitable for radiotherapy isolation protection; the method is convenient to operate, reasonable in reaction time and beneficial to industrial mass production.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to a cross-linked gel for isolation, a preparation method and application. Background technique [0002] Hyaluronic acid, also known as hyaluronic acid, is an acidic mucopolysaccharide. It is an important basic substance for skin suppleness, and it is also a component of the human body. It has a special water-retaining effect, and its weight is as high as 100 times its own weight. It is the most moisturizing substance found in nature so far. It is an ideal natural moisturizing factor. Because of its excellent biocompatibility, it is widely used in various ophthalmic operations, such as lens implantation, corneal transplantation and anti-glaucoma surgery. It is also used to treat arthritis and accelerate wound healing. [0003] Gelatin, without a fixed structure and relative molecular weight, is partially degraded by collagen in connective tissues such as animal skin, bone, sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08L5/08C08L89/00
CPCC08J3/24C08J2305/08C08J2489/00C08J2389/00C08J2405/08
Inventor 沈延臻
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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