Preparation method of hydrogen isotope substituted acid

Abstract

The invention belongs to the field of preparation of hydrogen isotope substituted acid, and particularly discloses a preparation method of hydrogen isotope substituted acid, which comprises the following steps: filling H-type sulfonic cation exchange resin into a cylindrical container to prepare an ion exchange column; introducing the water containing the hydrogen isotope into an ion exchange column, and carrying out hydrogen isotope and hydrogen exchange on the hydrogen isotope and the H-type sulfonic cation exchange resin in the ion exchange column to obtain the sulfonic cation exchange resin containing the hydrogen isotope; dissolving a metal salt of a corresponding acid radical in water containing hydrogen isotope to prepare a salt solution; and continuously flowing the prepared salt solution through the hydrogen isotope sulfonic cation exchange resin in S2 to obtain a hydrogen isotope substituted acid solution. The solid ion exchange resin is used as a medium, the acid substitution process is mild, the operation is simple, the utilization rate of the hydrogen isotope raw material can be greatly improved, and continuous production can be realized.

Description

technical field [0001] The invention belongs to the technical field of preparation of hydrogen isotope substituted acids, in particular to a preparation method of hydrogen isotope substituted acids. Background technique [0002] Hydrogen isotope substitution acid is an important isotope labeling reagent. Hydrogen and protium in nature ( 1 H), deuterium ( 2 H), tritium ( 3 H) There are three isotope forms, among which deuterated acid reagents are mainly used in nuclear magnetic resonance analysis, which can be used to adjust the pH of the sample solution and prepare deuterium-labeled compounds; while tritiated acid is mainly used to synthesize tritium-labeled substances. Hydrogen isotopes (mainly deuterium ( 2 H) and tritium ( 3 H)) Substituted acid is currently mainly prepared by batch method, that is, it is produced in the form of multiple exchanges of heavy water or tritium water. Separation of acid and water, after the separation, add new heavy water or tritium wate...

AI Technical Summary

Problems solved by technology

Hydrogen isotopes (mainly deuterium ( 2 H) and tritium ( 3 H)) Substituted acid is currently mainly prepared by batch method, that is, it is produced in the form of multiple exchanges of heavy water or tritium water. Separation of acid and water, after the separation, add new heavy water or tritium water to the acid for exchange, so it has a long production cycle, and a large amount of heavy water or tritium water with different abundances is produced during the process, resulting in a large consumption of hydrogen isotope water raw materials The problem

And because the separation between acid and water is difficult, it is difficult to completely remove the water in the hydrogen isotope-substituted acid. Therefore, in order to remove the water in the hydrogen-isotope-substituted acid, relatively high energy consumption is required.