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Preparation method of natural deep eutectic perilla leaf extract hydrogel

A perilla leaf extract and deep eutectic technology, applied in medical science, bandages, etc., can solve the problems of three-dimensional network hydrogel in natural deep eutectic solution, and achieve convenient and simple follow-up processing and high extraction efficiency , the effect of enhancing the stability

Pending Publication Date: 2022-03-22
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no related reports on the use of natural active extracts from natural deep eutectic solutions for the preparation of three-dimensional network hydrogels

Method used

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  • Preparation method of natural deep eutectic perilla leaf extract hydrogel
  • Preparation method of natural deep eutectic perilla leaf extract hydrogel
  • Preparation method of natural deep eutectic perilla leaf extract hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Perilla leaf extract preparation

[0021] Wash the fresh perilla leaves and mix them with distilled water. The mass ratio of perilla leaves:distilled water is 1:20. The mixture was flash-extracted, filtered, centrifuged at 5000 r / min for 15 min, and the supernatant was freeze-dried to obtain perilla leaf water extract powder.

Embodiment 2

[0022] Embodiment 2 Preparation of natural deep eutectic perilla leaf extract hydrogel

[0023] Mix 5 g of mannose-choline chloride (molar ratio 1:2), heat to 85°C, and stir at a constant speed for 1 hour to obtain a clear, transparent viscous liquid. Add perilla leaf extract 2g in Example 1, 2.06g dopamine, 0.142g hydroxyethyl methacrylate (HEMA) and 0.171g 2-(dimethylamine)-ethyl methacrylate (DMAEMA) and mix well , cross-linked at 35°C for 24h to obtain hydrogel A.

Embodiment 3

[0024] Embodiment 3 Preparation of natural deep eutectic perilla leaf extract hydrogel

[0025] Mix 10 g of mannose-choline chloride (molar ratio 1:2), heat to 85°C, and stir at a constant speed for 1 hour to obtain a clear, transparent viscous liquid. Add 2g of perilla leaf extract in Example 1, 1.412g dopamine, 0.284g hydroxyethyl methacrylate (HEMA) and 0.342g 2-(dimethylamine)-ethyl methacrylate (DMAEMA) and mix well , cross-linked at 35°C for 24h to obtain hydrogel B.

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Abstract

The invention discloses a preparation method of natural deep eutectic perilla leaf extract hydrogel. The preparation method comprises the following steps: by taking the perilla leaf extract as a raw material, adding a natural deep eutectic solution, dopamine, hydroxyethyl methylacrylate and 2-(dimethylamine)-ethyl methacrylate, fully and uniformly mixing, and carrying out cross-linking reaction at 30-40 DEG C to prepare the wound dressing hydrogel based on the natural deep eutectic perilla leaf extract, the natural deep eutectic solution is composed of mannose and choline chloride in a molar ratio of 1: 2. The stability of a hydrogel network structure can be improved by utilizing the high extraction efficiency of a natural deep eutectic solution composed of mannose and choline chloride on active ingredients of the perilla leaves and a three-dimensional composite network formed by hydrogen bonds and monomers in a natural deep eutectic solution system; therefore, the hydrogel with good physical performance and antibacterial performance is prepared, can be used as a medical wound dressing, and has a good application prospect.

Description

technical field [0001] The invention relates to a preparation method of natural deep eutectic perilla leaf extract hydrogel, which belongs to the technical field of medical materials. Background technique [0002] Hydrogel is a kind of hydrophilic polymer material with a three-dimensional network structure. It can absorb up to 70% of its own weight in water and swell without dissolving. It has good biocompatibility and high similarity with extracellular matrix. Support cell proliferation and migration, highly simulate soft tissue. In recent years, hydrogel has attracted much attention in the field of biomedical materials. The main applications are but not limited to wound dressings, human soft tissue filling, corneal contact lenses, drug-loaded matrix, 3D organ printing, etc., and the scope of application is also expanding to the food industry. , chemical valves, machinery manufacturing and other fields. As far as wound dressings are concerned, traditional wound dressings ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/14C08F220/34C08F220/20A61L26/00
CPCC08J3/075C08F220/34A61L26/0057A61L26/008A61L26/0014A61L26/0066A61L2300/30A61L2300/404A61L2300/232A61L2300/208C08J2333/14C08L33/14C08F220/20
Inventor 易封萍陈梓谦吴恺文
Owner SHANGHAI INST OF TECH
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