Bioglass-entrapped dual-network self-healing hydrogel as well as preparation method and application of bioglass-entrapped dual-network self-healing hydrogel

A bioglass, self-healing technology, applied in medical science, bandages, etc., can solve the problems of chronic wound recurrence, poor primary treatment effect, persistent infection, etc., and achieve environmental protection and safety of raw materials, good adhesion performance and biological safety. , the effect of accelerating healing

Active Publication Date: 2022-03-25
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main causes of chronic wound recurrence are diabetes, persistent infection, poor response to primary treatment, etc.

Method used

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  • Bioglass-entrapped dual-network self-healing hydrogel as well as preparation method and application of bioglass-entrapped dual-network self-healing hydrogel
  • Bioglass-entrapped dual-network self-healing hydrogel as well as preparation method and application of bioglass-entrapped dual-network self-healing hydrogel
  • Bioglass-entrapped dual-network self-healing hydrogel as well as preparation method and application of bioglass-entrapped dual-network self-healing hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of the dual-network self-healing hydrogel loaded with bioglass of the present embodiment comprises the following steps:

[0031] (1), after dissolving 1.5g sodium alginate in 100ml deionized water to form an aqueous solution to form a 1.5wt% aqueous solution, add 2g sodium periodate to protect from light for 6 hours, add 4g ethylene glycol to terminate the reaction, dialyze and freeze-dry to obtain oxidized seaweed Sodium acid;

[0032] (2) Dissolve xanthan gum and oxidized sodium alginate in deionized water at a mass ratio of 2:1, dissolve at 80°C for 0.1 hour, and after it is completely dissolved, add dopamine hydrochloride with a mass ratio of 10:1:1 , fucoidan and bioglass, after fully stirring, let it stand still, and the double network self-healing hydrogel encapsulating bioglass can be obtained.

[0033] Among them, the mass ratio of bioglass to xanthan gum is 1:1000.

[0034] figure 1 It is the rheological schematic diagram of the dual ...

Embodiment 2

[0038] The preparation method of the dual-network self-healing hydrogel loaded with bioglass of the present embodiment comprises the following steps:

[0039] (1), after dissolving 1.8g sodium alginate in 100ml deionized water to form an aqueous solution to form a 1.8wt% aqueous solution, add 1g sodium periodate to protect from light for 5 hours, add 3g ethylene glycol to terminate the reaction, dialyze and freeze-dry to obtain oxidized seaweed Sodium acid;

[0040] (2) Dissolve xanthan gum and oxidized sodium alginate in deionized water at a mass ratio of 1:1, dissolve at 60°C for 0.15h, and after it is completely dissolved, add dopamine hydrochloride with a mass ratio of 10:1:1 , fucoidan and bioglass, after fully stirring, let it stand still, and the double network self-healing hydrogel encapsulating bioglass can be obtained.

[0041] Among them, the mass ratio of bioglass to xanthan gum is 1:800.

Embodiment 3

[0043] The preparation method of the dual-network self-healing hydrogel loaded with bioglass of the present embodiment comprises the following steps:

[0044] (1), after dissolving 0.8g sodium alginate in 100ml deionized water to form an aqueous solution to form a 0.8wt% aqueous solution, add 0.6g sodium periodate and react in the dark for 4 hours, add 2.4g ethylene glycol to terminate the reaction, dialyze and freeze-dry to obtain Oxidized sodium alginate;

[0045] (2) Dissolve xanthan gum and oxidized sodium alginate in deionized water at a mass ratio of 2:1, dissolve at 70°C for 0.3h, and after it is completely dissolved, add dopamine hydrochloride with a mass ratio of 15:1:1 , fucoidan and bioglass, after fully stirring, let it stand still, and the double network self-healing hydrogel encapsulating bioglass can be obtained.

[0046] Among them, the mass ratio of bioglass to xanthan gum is 1:900.

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Abstract

The invention provides bioglass-entrapped dual-network self-healing hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: forming a first cross-linked network by hydrogen bond cross-linked xanthan gum; oxidized sodium alginate and calcium ions are chelated to form a second cross-linked network, the calcium ions are derived from slow release of bioglass entrapped in the system, dopamine and oxidized sodium alginate form covalent linkage under the action of Schiff base, the adhesion of the system is improved, and fucoidan entrapped in gel can realize long-time slow release; the bioglass-entrapped dual-network self-healing hydrogel system disclosed by the invention has good adhesion performance and biological safety, and can keep a moist environment for a wound and accelerate healing of the wound; the preparation method disclosed by the invention is short in preparation period, simple and feasible, and environment-friendly and safe in raw materials, thereby having a good popularization prospect.

Description

technical field [0001] The invention belongs to the fields of polymer materials and biomedical engineering, and in particular relates to a double-network self-healing hydrogel containing biological glass and a preparation method and application thereof. Background technique [0002] Disruption of the normal structure of skin cells is defined as a wound. One of the typical reactions that everyone goes through after an injury is the normal repair response. Basically, there are two types of wounds, namely acute wounds and chronic wounds. An acute wound is one that heals completely within 8-12 weeks with minimal scarring, while a chronic wound does not fully heal within 12 weeks and may recur. The main causes of chronic wound recurrence are diabetes, persistent infection, poor response to primary treatment, etc. Hydrogel is a 3D polymer network composed of a hydrophilic backbone with good water retention capacity. Due to the structural similarity between hydrogel and tissue ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J3/075C08L5/04C08L5/00C08K5/18C08K3/32C08K3/34C08K3/40A61L26/00
CPCC08J3/246C08J3/243C08J3/075A61L26/0023A61L26/0004A61L26/008C08J2305/04C08J2405/00C08J2405/04C08J2305/00C08K2003/325C08K5/18C08K3/34C08K3/40C08L5/04C08L5/00
Inventor 袁伟忠赵诺亚
Owner TONGJI UNIV
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