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Application of traditional Chinese medicine composition in medicine for preventing and treating myelosuppression

A technology for myelosuppression and composition, which is applied to the application field of ginseng-guben traditional Chinese medicine composition in the prevention or treatment of myelosuppression protection, and achieves the effects of increasing animal immunity, prolonging survival period and improving quality of life

Pending Publication Date: 2022-03-29
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Prior to this application, there was no precedent for using ginseng-boosting formula products in the prevention and treatment of myelosuppression

Method used

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  • Application of traditional Chinese medicine composition in medicine for preventing and treating myelosuppression
  • Application of traditional Chinese medicine composition in medicine for preventing and treating myelosuppression
  • Application of traditional Chinese medicine composition in medicine for preventing and treating myelosuppression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Protective Effect of Ginseng Guben Oral Liquid on Myelosuppressed Mice Induced by Cyclophosphamide for Injection

[0031] Experimental animals:

[0032] ICR male mice with a body weight of 18-22 grams were fed with conventional feed and had free access to water and food. The mice were acclimatized for one week before establishing models and drug intervention experiments.

[0033] experimental method:

[0034] Divide 50 mice randomly into 5 groups according to body weight: normal group, model group, ginseng Guben oral liquid 1ml / kg, ginseng Guben oral liquid 2ml / kg, ginseng Guben oral liquid 4ml / kg, 10 mice in each group . In addition to the normal group, the model group and each administration group received intraperitoneal injection of cyclophosphamide (50 mg / kg), once a day, for 5 consecutive days to establish a bone marrow suppression model. The normal group was replaced by the same amount of normal saline. Three days after successful modeling, the admi...

Embodiment 2

[0043] Example 2 Protective Effect of Ginseng Guben Oral Liquid on Sigio Capsule-Induced Myelosuppressed Mice

[0044] Experimental animals:

[0045] ICR male mice with a body weight of 18-22 grams were fed with conventional feed and had free access to water and food. The mice were acclimatized for one week before establishing models and drug intervention experiments.

[0046] experimental method:

[0047] Divide 50 mice randomly into 5 groups according to body weight: normal group, model group, ginseng Guben oral liquid 1ml / kg, ginseng Guben oral liquid 2ml / kg, ginseng Guben oral liquid 4ml / kg, 10 mice in each group . In addition to the normal group, the model group and each administration group were intragastrically administered S-1 capsules (12 mg / kg), once a day, for 12 consecutive days to establish a bone marrow suppression model. The normal group was replaced by the same amount of normal saline. Three days after successful modeling, the administration group was given...

Embodiment 3

[0056] Example 3 Protective Effect of Ginseng Guben Oral Liquid on Oxaliplatin Injection-induced Myelosuppression Mice

[0057] Experimental animals:

[0058] ICR male mice with a body weight of 18-22 grams were fed with conventional feed and had free access to water and food. The mice were acclimatized for one week before establishing models and drug intervention experiments.

[0059] experimental method:

[0060] Divide 50 mice randomly into 5 groups according to body weight: normal group, model group, ginseng Guben oral liquid 1ml / kg, ginseng Guben oral liquid 2ml / kg, ginseng Guben oral liquid 4ml / kg, 10 mice in each group . In addition to the normal group, the model group and each administration group were intraperitoneally injected with oxaliplatin (30 mg / kg), twice a day for 14 consecutive days to establish a bone marrow suppression model. The normal group was replaced by the same amount of normal saline. Three days after successful modeling, the administration group...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a ginseng foundation-consolidating traditional Chinese medicine composition prepared from ginseng, rehmannia, poria cocos, moutan bark, prepared rehmannia root, dogwood, Chinese yam, rhizoma alismatis, asparagus cochinchinensis and radix ophiopogonis in preparation of a medicine for preventing and / or treating myelosuppression.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the application of a traditional Chinese medicine composition of ginseng and ginseng in preventing or treating myelosuppression. Background technique [0002] Myelosuppression is a decrease in the activity of blood cell precursors in the bone marrow. Both red and white blood cells in the bloodstream originate from stem cells in the bone marrow. Blood cells in the bloodstream are short-lived and often need to be replenished constantly. Stem cells, the precursors of blood cells, must divide rapidly for timely replenishment. Chemotherapy and radiation therapy, as well as many other anti-tumor treatments, target rapidly dividing cells, often resulting in the suppression of normal bone marrow cells. Among them, most chemotherapeutic drugs can also cause different degrees of bone marrow suppression, such as alkylating agents (CTX), mitomycin, platinu...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P7/00
CPCA61K36/258A61K36/804A61K36/076A61K36/71A61K36/65A61K36/40A61K36/8945A61K36/884A61K36/8965A61K36/8968A61P7/00A61K2300/00
Inventor 李斌桂磊
Owner SHANDONG NEWTIME PHARMA
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