Exogenous peptide mediated membrane fusion drug delivery system and evaluation method thereof

Abstract

The invention belongs to the technical field of medical supplies, and particularly relates to an exogenous peptide mediated membrane fusion drug delivery system and an evaluation method thereof. The exogenous peptide-mediated membrane fusion drug delivery system is characterized by comprising an exogenous peptide-mediated membrane fusion receptor and an exogenous peptide-mediated membrane fusion ligand, a coiled spiral can be formed between the exogenous peptide-mediated membrane fusion receptor and the exogenous peptide-mediated membrane fusion ligand, and drug delivery can be mediated through a membrane fusion effect. According to the exogenous peptide mediated membrane fusion drug delivery system disclosed by the invention, the drug utilization rate is increased, the damage to a non-target part is reduced, and the technical effects of higher targeting property, small damage to the non-target part, high drug utilization rate and the like are achieved. The method for evaluating the exogenous peptide-mediated membrane fusion drug delivery system related to the method can be used for quantitatively evaluating the efficiency of a targeted drug delivery system, and is beneficial to accurate control of the drug effect and the drug dosage clinically.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to an exogenous peptide-mediated membrane fusion drug delivery system and an evaluation method thereof. Background technique [0002] Targeted drug delivery system refers to the drug delivery system that helps carriers, ligands or antibodies to selectively concentrate and localize the drug in the target tissue, target organ, target cell or intracellular structure through local administration of the gastrointestinal tract or systemic blood circulation. Drug system, due to its affinity and selectivity to tissues, targeted drug delivery can reduce the dosage of drugs, reduce toxicity, reduce adverse reactions, prolong the duration of drug action, and improve the therapeutic effect. [0003] Most of the existing targeted drug delivery systems rely on endogenous receptors to function, such as transferrin, folic acid, or artificially synthesized antibodies and their f...

AI Technical Summary

Problems solved by technology

Moreover, in the existing targeted drug delivery system, due to the low binding ratio of receptors and ligands, the effective dose of targeted drug delivery is limited

Moreover, there is no method in the existing targeted drug delivery system that can quantitatively assess the drug delivery efficiency, which is not conducive to the accurate control of drug dosage in clinical practice.

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