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Method for continuously preparing monobromide of toluene derivative

A technology of derivatives and bromines, which is applied in the field of continuous preparation of monobromines of toluene derivatives, can solve the problems of low efficiency of batch reaction and high safety risk of bromine, achieve high purity, high reaction conversion rate, and avoid bromine The effect of element leakage

Pending Publication Date: 2022-04-05
SHANGHAI SYNTHEALL PHARM CO LTD +1
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Problems solved by technology

[0007] The present invention provides a method for continuously preparing monobrominated products of toluene derivatives in order to solve the defects of low batch reaction efficiency and high safety risk of using bromine when toluene derivatives are subjected to bromination reactions in the prior art. method

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  • Method for continuously preparing monobromide of toluene derivative
  • Method for continuously preparing monobromide of toluene derivative

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Embodiment 1

[0079] The method for the monobromide of the continuous preparation of toluene derivative in embodiment 1 adopts continuous preparation device to carry out;

[0080] Such as figure 1 As shown, the continuous preparation device includes a reactor 1, a first mixer 2, a second mixer 3, a first membrane separator 5, a third mixer 4, a second membrane separator 6 and a fourth mixer connected in sequence twenty three;

[0081] The method includes the following steps:

[0082] (1) after the delivery pipeline of reaction raw material and the delivery pipeline of hydrobromic acid solution converge, then with the delivery pipeline of sodium bromate solution, and connect with the inlet of reactor 1; Sodium bromate solution, hydrogen bromide After acid solution and reaction raw material are transported in the reactor 1, react under light condition, obtain reaction product; The concentration of sodium bromate solution is 2.1mol / L; The massfraction of hydrobromic acid is 48%; Reaction raw...

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Abstract

The invention discloses a method for continuously preparing monobromide of toluene derivatives. The method comprises the following steps: S1, conveying a sodium bromate solution, a hydrobromic acid solution and reaction raw materials into a reactor for reaction to obtain a reaction product; s2, conveying the reaction product and a quenching agent solution to a first mixer for quenching reaction to obtain a quenched product; s3, conveying the quenching product and an extraction solvent to a second mixer, then conveying the quenching product and the extraction solvent to a first membrane separator for liquid-liquid separation, and collecting to obtain a first oil phase; and S4, conveying the water and the first oil phase to a third mixer, then conveying the water and the first oil phase to a second membrane separator for liquid-liquid separation, and collecting to obtain a second oil phase. The preparation method provided by the invention can be used for continuously preparing the monobromide of the toluene derivative, and has the advantages of high reaction purity, high reaction efficiency, high conversion rate of reaction raw materials and low safety risk.

Description

technical field [0001] The present invention relates to a method for the continuous preparation of monobrominated compounds of toluene derivatives. Background technique [0002] The bromination reaction is the reaction of toluene derivatives and bromine to form a bromine. The preparation of traditional monobromide is to react with N-bromosuccinimide (NBS) as brominated reagent, but the solubility of NBS is not good, so need a large amount of reaction solvents to cause this reaction cost very high, and traditional Both processes require the addition of initiators. [0003] The prior art has improved the traditional bromination process. For example, using bromine as a bromine source by photochemical methods can generate bromine free radicals to react without using a free radical initiator. The reaction formula is as follows: [0004] [0005] However, when carrying out this reaction in the prior art, all adopt batch reaction, and reaction efficiency is low. In addition, ...

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Application Information

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IPC IPC(8): C07C17/14C07C22/04B01J19/00
Inventor 杜晨辉刘巧伦疏其朋李星王永正陈晶陈礼科朱瑞恒孙宝权杨洪伟傅小勇
Owner SHANGHAI SYNTHEALL PHARM CO LTD
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