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Application of epigallocatechin gallate in preparation of medicine for preventing or treating systemic jellyfish toxin poisoning

A technology of epigallocatechin and gallate, applied in the field of biomedicine, can solve problems such as prevention or treatment of systemic poisoning of jellyfish toxin, achieve good clinical application promotion value, improve blood pressure reduction, and improve survival rate Effect

Pending Publication Date: 2022-04-08
中国人民解放军海军特色医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there are no relevant reports about the use of EGCG in the prevention or treatment of jellyfish toxin systemic poisoning

Method used

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  • Application of epigallocatechin gallate in preparation of medicine for preventing or treating systemic jellyfish toxin poisoning
  • Application of epigallocatechin gallate in preparation of medicine for preventing or treating systemic jellyfish toxin poisoning
  • Application of epigallocatechin gallate in preparation of medicine for preventing or treating systemic jellyfish toxin poisoning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the groping of mouse intravenous injection jellyfish toxin (NnV) lethal dose

[0038] 1. Experimental method

[0039] The ICR mice were randomly divided into 5 groups (n=3), and different doses of NnV (0.42mg / kg, 0.5mg / kg, 0.6mg / kg, 0.72mg / kg, 0.86mg / kg, the solvent was physiological saline, dilute to 0.1ml), and observe the effects of different doses of NnV on the survival of mice.

[0040] 2. Experimental results

[0041] When the toxin dose was ≥0.6mg / kg, the mice died within 2 hours. When the toxin dose was 0.5 mg / kg, the survival time of the mice was prolonged, but all died within 1 day. When the toxin dose was 0.42mg / kg, some mice could survive for more than 1 week.

Embodiment 2

[0042] Embodiment 2: Survival analysis of NnV poisoned mice

[0043] 1. Experimental method

[0044] According to the results of Example 1, the dose range of NnV was re-determined, and the number of mice in each group was expanded. The ICR mice were randomly divided into 5 groups (n=10), and different doses of NnV (0.35mg / kg, 0.42mg / kg, 0.45mg / kg, 0.5mg / kg, 0.6mg / kg, the solvent was physiological saline, dilute to 0.1ml), and observe the effects of different doses of NnV on the survival of mice.

[0045] 2. Experimental results

[0046] Such as figure 1 As shown, when the toxin dose was less than or equal to 0.42mg / kg, the mice showed an excitatory response in the early stage, and gradually appeared lethargic, unresponsive, and curled up after 10 minutes, and some mice died within 3 days. When the toxin dose was 0.45mg / kg or 0.5mg / kg, the mice had shortness of breath, increased heartbeat, fatigue, lethargy, curling up, convulsions and death in the early stage. However, wh...

Embodiment 3

[0047] Embodiment 3: Exploration of the effective dose range of EGCG antagonizing lethal dose NnV

[0048] 1. Experimental method

[0049] EGCG was made into a 10mg / ml solvent with physiological saline. ICR mice were randomly divided into 5 groups (n = 2) and different doses of EGCG (100mg / kg, 80mg / kg, 40mg / kg, 20mg / kg, 10mg / kg) were mixed with 0.5mg / kg NnV, and then fixed with normal saline. The volume was reduced to 0.2ml, and injected into the tail vein, and the reaction and survival time of the mice were observed.

[0050] 2. Experimental results

[0051] Except one mouse died in the 10mg / kg EGCG group, all the other mice survived for 7 days. The mice in the dose group above 20mg / kg showed mild excitement in the early stage, and returned to normal after about 2 hours.

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Abstract

The invention relates to the field of biological medicines, in particular to application of epigallocatechin gallate (EGCG) in preparation of a medicine for preventing or treating systemic poisoning of jellyfish toxin. The invention provides a new application of EGCG, injection administration of EGCG can play an obvious role in preventing and treating a jellyfish toxin systemic poisoning animal model, and experimental results show that injection administration of EGCG can effectively prevent and treat jellyfish toxin systemic poisoning, so that an effective candidate drug is provided for developing a drug for preventing or treating jellyfish stings systemic poisoning, and the EGCG can be applied to prevention and treatment of jellyfish stings systemic poisoning. And reference is provided for clinical research of new application of the medicine.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of epigallocatechin gallate (EGCG) in the preparation of medicines for preventing or treating jellyfish toxin systemic poisoning. Background technique [0002] Jellyfish is a class of low-level invertebrate zooplankton in the aquatic environment, which has the characteristics of many types, large numbers and wide distribution. Affected by factors such as global warming, overfishing, and changes in biodiversity, jellyfish outbreaks occur frequently in sea areas around the world, seriously endangering the economic development of coastal areas and the safety and health of sea workers. [0003] Under normal circumstances, jellyfish stings immediately cause local symptoms such as pain, welt-like redness, or itching; when the toxin is further absorbed into the blood, systemic symptoms such as nausea, vomiting, or headache may occur; if a large amount of toxin enters the body,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P39/02
Inventor 张黎明王倩倩李捷张培培邹帅军张福海王钒柳国艳王蓓蕾
Owner 中国人民解放军海军特色医学中心
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